Oxytocin a threat to the eunuch community?

[chilliwilli (imported)]

I read in the paper today that a fellow has found that a naturally occurring substance seems to mimic many of the effects of castration.

Seems that prairie squirrels mate for life and the males are quite affectionate.

A neurotransmitter, oxytocin, is quite high in the male squirrels. When given to other ground squirrels, cousins of the prairie squirrel, similar types of bonding to the female and babies is observed.

Maybe oxytocin counteracts excessive testosterone.

chilli-

[bobbie (imported)]

They may be just too stoned

[ramses (imported)]

Biology of Reproduction, Vol 52, 1268-1273, Copyright © 1995 by Society for the Study of Reproduction

--------------------------------------------------------------------------------

ARTICLES

Effect of oxytocin on testosterone production by isolated rat Leydig cells is mediated via a specific oxytocin receptor

J Frayne and HD Nicholson

Department of Anatomy, School of Veterinary Science, University of Bristol, United Kingdom.

The effect of the neurohypophysial hormones oxytocin and arginine vasopressin (AVP) on testicular steroidogenesis was reevaluated by use of short-term (< 10 h) cultures of isolated adult rat Leydig cells. Oxytocin at 10(-9), 10(-7), and 10(-5) M concentrations significantly increased basal testosterone production in a dose-dependent manner but had no effect on LH-stimulated testosterone production. The specificity of the effect was determined by use of the specific oxytocin receptor antagonist (OTA). OTA from 10(-9) to 10(-5) M concentrations inhibited the oxytocin-stimulated increase in testosterone production. Furthermore, the oxytocin agonist Thr4 Gly7 oxytocin also induced a dose-dependent increase in basal testosterone production. In contrast, AVP from 10(-9) to 10(-5) M concentrations did not consistently affect basal testosterone production by isolated Leydig cells, but significantly decreased LH-stimulated testosterone production. Inclusion of 10(-7) and 10(-5) M OTA with 10(-7) M AVP did not alter the inhibitory effect of the AVP. These data show that oxytocin and AVP have different effects on testosterone production by Leydig cells in vitro and support the hypothesis that oxytocin acts in the testis through a specific oxytocin receptor.

[bobbie (imported)]

Biology of Reproduction, Vol 52, 1268-1273, Copyright © 1995 by Society for the Study of Reproduction

--------------------------------------------------------------------------------

ARTICLES

Effect of oxytocin on testosterone production by isolated rat Leydig cells is mediated via a specific oxytocin receptor

J Frayne and HD Nicholson

Department of Anatomy, School of Veterinary Science, University of Bristol, United Kingdom.

The effect of the neurohypophysial hormones oxytocin and arginine vasopressin (AVP) on testicular steroidogenesis was reevaluated by use of short-term (< 10 h) cultures of isolated adult rat Leydig cells. Oxytocin at 10(-9), 10(-7), and 10(-5) M concentrations significantly increased basal testosterone production in a dose-dependent manner but had no effect on LH-stimulated testosterone production. The specificity of the effect was determined by use of the specific oxytocin receptor antagonist (OTA). OTA from 10(-9) to 10(-5) M concentrations inhibited the oxytocin-stimulated increase in testosterone production. Furthermore, the oxytocin agonist Thr4 Gly7 oxytocin also induced a dose-dependent increase in basal testosterone production. In contrast, AVP from 10(-9) to 10(-5) M concentrations did not consistently affect basal testosterone production by isolated Leydig cells, but significantly decreased LH-stimulated testosterone production. Inclusion of 10(-7) and 10(-5) M OTA with 10(-7) M AVP did not alter the inhibitory effect of the AVP. These data show that oxytocin and AVP have different effects on testosterone production by Leydig cells in vitro and support the hypothesis that oxytocin acts in the testis through a specific oxytocin receptor.

Thanks but translate for us none medical types.

[nullorchis (imported)]

Translated it means

These studies keep my career alive and food on the table and I have no idea what I wrote or what it means. But it sure sounds "heady" and intelligent.

[jemagirl (imported)]

When I first read the title of this post I thought it was "OxyContin® a threat to the eunuch community?" and then I thought "Wow is Rush Limbaugh a eunuch?"

Oxytocin OxyContin® is there a difference?

[nutme248 (imported)]

Jemagirl,

ROFLMAO!!!!

Since I'll assume that Rush Limbaugh isn't a eunuch, he SHOULD have his 'nads bronzed for the good of the world.

Dave

When I first read the title of this post I thought it was "OxyContin® a threat to the eunuch community?" and then I thought "Wow is Rush Limbaugh a eunuch?"

Oxytocin OxyContin® is there a difference?

[artisticlicense (imported)]

It's a hormone used to induce labor. It may influence our ability to bond with others. Research still on-going.

The study builds upon previous knowledge of the important role oxytocin plays in the reproductive life of mammals. The hormone facilitates nest building and pup retrieval in rats, acceptance of offspring in sheep, and the formation of adult pair-bonds in prairie voles. In humans, oxytocin stimulates milk ejection during lactation, uterine contraction during birth, and is released during sexual orgasm in both men and women. (July issue of Psychiatry - 1999)

From Wikipedia; Oxytocin (IPA: /ˌɔk.sɪ.ˈtoʊ.sɪn/) (Greek, "quick birth") is a mammalian hormone that also acts as a neurotransmitter in the brain.

Large article in English > http://en.wikipedia.org/wiki/Oxytocin ("Men, raise the oxytocin!"[/B] (http://www.picayuneitem.com/features/lo ... 30453.html)

Cuddling is not a normal male activity; "...plays a central role in bonding mothers to their offspring and in social behaviour generally." ( Nature (http://dx.doi.org/10.1038/nature03701) 435, 673-676 (2 June 2005) | doi:10.1038/nature03701; Received 20 April 2005; Accepted 5 May 2005 )

Another nice article; "Cuddle chemical' could treat mental illness" (http://www.newscientist.com/article/mg1 ... ?full=true)

Now go cuddle.

[mrt (imported)]

When I first read the title of this post I thought it was "OxyContin® a threat to the eunuch community?" and then I thought "Wow is Rush Limbaugh a eunuch?"

Oxytocin OxyContin® is there a difference?

Not that I know of but he often talks about the Voluntary Castrati which annoys the hell out of me.

[micropenis (imported)]

Not that I know of but he often talks about the Voluntary Castrati which annoys the hell out of me.

Rush a eunuch? Well, he was caught with a large supply of Viagra at a border crossing. I don't know if he is a eunuch but he and other conservative talk radio hosts talk about castrati often enough to make me wonder. I think they have castration fantasies of thier own. It would do them good to get-r-done. It would do the rest of us some good too.