Longevity Factors
Posted: Mon Mar 05, 2007 5:23 pm
The impression I have gotten from several posts, is that, when some of the archive members had elective orchiectomies, one of the reasons they chose to have the surgery, was that they thought there would be positive health effects from the operation. And I've read in a couple of places on the message board, that there has been research which indicates that the reduction of testosterone in the body, does increase lifespan.
Obviously, someone who has had an orchiectomy, can't get testicular cancer, and lowering testosterone levels in the body has been shown to slow or stop the progress of prostate cancer. These effects would unquestionably tend to increase lifespan, but I don't think it could account for some of the claims for increased lifespan. I have seen statements to the effect that individuals who have had orchiectomies live an average of more than six years longer than those who haven't had the surgery. Because testicular cancer is relatively rare, and because prostate cancer is a slow-developing condition which usually isn't the cause of death of those who have the disease, I would tend to think that reduction of those two cancers in the sex organs, couldn't account for more than a fraction of the reported longevity increase.
So, has anyone researched what the specific physical benefits of reduction in testosterone levels are? Do men using drugs to reduce testosterone levels, show increases in lifespan as well as those who have had the surgery? And are there long-term statistical records which support the claims for lifespan increases?
Since men are more likely to suffer from heart disease than women are, I would tend to suspect that, if there are substantial increases in lifespan for males whose gonads have been excised, the reason is largely because of a reduction in cardiovascular disease. However, it seems possible that there are other things involved. For one thing, I have read that removal of the gonads in both men and women, causes a decrease in the basal metabolism rate. This also happens to people on restricted-calorie diets, and appears to be associated with increased lifespan for people on those diets--perhaps the reduction in metabolic rate might have a similar effect of enhancing longevity for individuals who have had the testes removed. Also, the idea of the "eunuch calm" would suggest that there are psychological factors which might provide a more positive mental outlook, and therefore increase the likelihood of survival to a greater age. Research on supercentenarians (those who live to be over 110 years old) seems to indicate that mental outlook had an effect on their longevity.
At the same time, there are some effects of low testosterone levels which would seem to have some possible deleterious effects on both general health and longevity. The greater tendency of those without gonads to gain weight seems to be well substantiated, and obesity is clearly associated with shorter lifespans. Loss of bone density leading to osteoporosis also seems to be an effect of low hormone levels, and, in some cases, that would seem likely to be associated with shorter lifespans. And, of course, in the first couple of years after hormone levels are lowered, it appears that chronic depression can lead to suicide.
Another issue on this topic might be the possibility that there is an optimum level of testosterone, somewhere between the average for men with gonads, and the low levels for those without the organs, at which there would be an optimum lifespan and the best level of general health. I think that some of those who are using drugs to reduce testosterone levels, have reported that they have found certain levels of the hormone which seem best for them individually.
Obviously, someone who has had an orchiectomy, can't get testicular cancer, and lowering testosterone levels in the body has been shown to slow or stop the progress of prostate cancer. These effects would unquestionably tend to increase lifespan, but I don't think it could account for some of the claims for increased lifespan. I have seen statements to the effect that individuals who have had orchiectomies live an average of more than six years longer than those who haven't had the surgery. Because testicular cancer is relatively rare, and because prostate cancer is a slow-developing condition which usually isn't the cause of death of those who have the disease, I would tend to think that reduction of those two cancers in the sex organs, couldn't account for more than a fraction of the reported longevity increase.
So, has anyone researched what the specific physical benefits of reduction in testosterone levels are? Do men using drugs to reduce testosterone levels, show increases in lifespan as well as those who have had the surgery? And are there long-term statistical records which support the claims for lifespan increases?
Since men are more likely to suffer from heart disease than women are, I would tend to suspect that, if there are substantial increases in lifespan for males whose gonads have been excised, the reason is largely because of a reduction in cardiovascular disease. However, it seems possible that there are other things involved. For one thing, I have read that removal of the gonads in both men and women, causes a decrease in the basal metabolism rate. This also happens to people on restricted-calorie diets, and appears to be associated with increased lifespan for people on those diets--perhaps the reduction in metabolic rate might have a similar effect of enhancing longevity for individuals who have had the testes removed. Also, the idea of the "eunuch calm" would suggest that there are psychological factors which might provide a more positive mental outlook, and therefore increase the likelihood of survival to a greater age. Research on supercentenarians (those who live to be over 110 years old) seems to indicate that mental outlook had an effect on their longevity.
At the same time, there are some effects of low testosterone levels which would seem to have some possible deleterious effects on both general health and longevity. The greater tendency of those without gonads to gain weight seems to be well substantiated, and obesity is clearly associated with shorter lifespans. Loss of bone density leading to osteoporosis also seems to be an effect of low hormone levels, and, in some cases, that would seem likely to be associated with shorter lifespans. And, of course, in the first couple of years after hormone levels are lowered, it appears that chronic depression can lead to suicide.
Another issue on this topic might be the possibility that there is an optimum level of testosterone, somewhere between the average for men with gonads, and the low levels for those without the organs, at which there would be an optimum lifespan and the best level of general health. I think that some of those who are using drugs to reduce testosterone levels, have reported that they have found certain levels of the hormone which seem best for them individually.