I get several emails about this since my education is rather known here, now understand im not licensed and this is not professional advice but im making this post so i can just refer people to it in the future for reference. Most of the info is just from other protocols with my own tweaks. If anyone wants to add comments, feel free.

First WARNING, Chemical castration and estrogen can cause irreversible effects even after short turn use. It is advised to seek professional help and or counseling BEFORE starting any chemical castration protocol. This posting is meant as a harm reduction tool to keep people from overdosing on these medicines. Long term libido reduction and function changes have been reported from just as little as a month of chemical castration.

This protocol has now been reviewed by 3 bonafide physicians, while hey cant endorse the practice of self administration, their suggestions have helped evolve this into the refinement it is today. All 3 believe it is now in a "least harm" category of chemical alteration and have it in their own materials as a reference aid.

Before treatment is started, the following blood tests should be done:

• Total Testosterone

• SHBG

• DHT

• Estradiol (specify “ultrasensitive” assay for males unless allready on E)

• LH

• FSH

• Prolactin

• Cortisol

• Thyroid Panel

• CBC

• Comprehensive Metabolic Panel

• Lipid Profile

• PSA (if over 40)

• IGF-1

any parameter out of whack should be investigated before starting chemical castration.

To lower DHT:

5mg Finasteride 1x day

(blocks "male hormone" dht which causes MPB and prostate enlargement, also secondary male sexual features)

To Lower Testosterone:

50mg 2x Day Androcur (Cyproterone acetate) also known as Cyproterone and Siterone

OR

100mg 2x Day Spirotone (Spironolactone)

OR

LUPRON DEPOT, every 4 Months 30 mg

(luprodepot is very stong but very expensive, androcur is next, spirotone is last but cheap)

To Feminize:

2-8mg of Estrofem sublingualy as tolerated by your liver

Oral estrogens can cause significantly more hepatic and cardiac impairment than injected, and is only recommended if shots can not be tolerated weekly.

OR

20mg-40mg Bi Weekly Progynon Depot (Estradiol Valerate, Oestradiol Valerate) Deep IM Injection, must be dosed per the individual person. Blood tests indicating E levels should be dont to assure you do not exceed maximum safe levels. Average dose for a fit individual is 20mg bi-weekly.

OPTIONAL when using Estradiol Valerate : 2mg Daily Estrofem sublingualy (only if needed for constant feed of E from the up/down cycle of the injected estrogen, estrofem has the lowest emotional liability of all the oral estrogens, if your body is sensitive or you dont need it, you can leave out the oral estrogen. Injected is the safest method of delivery and best for your liver.)

Dermal (gel and patch) estrogens are not addressed by this protocol as they tens to have too high a cost for M2F transformation. They are one of the safest delivery methods however, dosage should be according to your tolerance.

OPTIONAL: 150mg Monthly Depo-Provera Some say it promotes more breast production, the results varry.

Lactation or rapid breast enlargement:(only to be done when breast development has reached significant levels)

20mg 4x Day Motilium (Domperidone) (may induce lactation, but also increases the hormone prolactin which increases breast growth significantly)

Simple protocol; chemical castration with slow feminization:

50mg 2x Day Androcur (Cyproterone acetate) also known as Cyproterone and Siterone

4mg Dayly Estrofem sublingualy

Simple protocol; chemical castration with gentle T lowering:

Depo Provera 300mg 1st dose

Afterwards, 150mg every 2-3 weeks as needed.

Alternative chemical castration with no shots and quicker T lowering:

50mg Androcur 2x a day for 3 weeks (Cyproterone acetate) also known as Cyproterone and Siterone, then 50 mg 1x a day for maintenance.

Some people can go as low as 25mg and have their T level brought to castrate. This does not provide a supplemental hormone like depo-provera so be mindful of depression and other side effects.

all items are able to had without a prescription at inhousepharmacy.com except lupron depot

A doctor monitoring you with a heptic blood panel twice a year is highly recommended.

everyone is different but mental changes normally start in 2 weeks to a month, physical changes start within 6 months to a

year.

LIST OF SIDE EFFECTS

NOTE! If you have a genetic predisposition to any of the below you might be in increased danger of its effect!

moderate to SEVERE suicidal level depression

anxiety

emotional instability (especially crying)

osteoporosis

hot & cold flashes

sweating

drowsiness

disturbed sleep

memory loss

testicular soreness; atrophy (shrinking)

breasts, swelling of (gynecomastia)

weight gain (may continue for a while after treatment)

impotence (during the period of treatment and for some months after)

high blood pressure (hypertension)

liver problems

The following symptoms may reflect serious problems.

Contact your doctor immediately.

abdominal pain*

anorexia* (persistent appetite loss)

bluish lips, fingernails, or palms of hands

dark urine (may reflect hyper bilirubinuria)*

dizziness (extreme) or fainting

fatigue, weakness

flu-like symptoms*

infections

itching, severe (pruritus)*

nausea*

numbness, coldness, or tingling of hands or feet

pain: bone, joints, pelvic

rash

tenderness on the right side of the upper abdomen*

urinary incontinence

urinary tract infection

vomiting*

weak and fast heartbeat

yellow eyes or skin*

* These may indicate liver-function problems.

Misc side effects seen in less than 2% of patients:

alcohol intolerance

anemia

arthritic symptoms

appetite loss

blood in urine

cholesterol and triglycerides increase

constipation

diarrhea (with Eulexin)

dry mouth

feet or lower legs, swelling of (peripheral edema)

flatulence

flu syndrome

hair change (decrease in pubic and axillary hair; facial hair grows more slowly)

headache

hyperglycemia (high blood sugar)

indigestion

itching

insomnia

methemoglobinemia (a crystalization in the blood)

nausea

nocturia (need to urinate frequently at night)

nervous and twitchy legs

pain: abdominal, back, chest, in right side

pressure: feeling of extreme pressure in head

prickling sensation on the skin

shortness of breath

weight loss

Note; this is not medical advice but rather recorded facts that can be looked up independently. Nothing I say or publish should be construed as professional advice or opinion.

This is great. Thanks for posting this and thanks for putting it in laymans language.

I was wondering if anyone can help me find what is right for me. I am transgendered but not QUITE sure of where I am on a gender scale. I lean towards female and would be perfectly content if I woke up one day as a female but am not quite ready to decide if transitioning to a full time female is right for me at this point in my life. What I am sure of is regardless of what I eventually decide, I don't want to be in the male range. So ultimately my goal is somewhere between andro and female. Also I know that I want to be feminine regardless so I want to cease T production to zero or miniscule amounts to prevent masculinization as well as remove my "physical" sex drive meaning I don't want any sex drive I have to be hormone induced (although I am not against being sexual).

I have been taking Spironolactone (from InHousePharmacy) since I was about 15-16 (I am 18 now). I started at 25mg and worked my way up over time to my current daily dose of 400mg (Yeah I know that seems high) with no ill effects. However, I still have a somewhat decent sex drive (not what would be considered "average" probably in the sexually active female range) and it really bothers me how often I get aroused even with the current dose I am taking. I feel that the Spironolactone is greatly reducing my T levels but that it's still an amount I am not comfortable with. Also, the current dose I am taking is expensive, incredibly nasty (most bitter thing EVER put in my mouth) and hard to keep up with. I decided to order 3 vials of Depo Provera because I feel a more permanent or long lasting effect is better for my lifestyle. HOWEVER, at first I though a proper dosage of DP would near eliminate my T production and cause my *you know whats* to atrophy (which would be incredibly great) but after reading around it seems that high doses are needed to simply lower sex drive in men. I was wondering what dosage would be best for me. Although I have not recieved bloodwork relating to my hormone levels, I "feel" as if my T levels are on the relative same level as a female on possibly the higher end of things.

I also am not taking Estrogen to balance it out (even low doses cause me to start to develope breasts which I am not ready for and I even lactatid once O.o). Soooo basically I either need some help finding a dosage of DP that works for me or a better alternative short of surgery. I have thought of Androcur but I didn't want a similar experience to Spiro where it takes a high dosage just to feel like I am eliminating most of it.Yes, I know I need a endocrinologist and plan to get one asap but need help in the mean time.

Thanks for any help you can give and sorry for the long post.

well androcur eliminates a significant amount more T than any dose of spiro. DP can be started slowly too, 150mg Bi or Tri weekly. Some times it takes allot of self experimentation.

Estrogen does tend to finish knocking out erections though..

Great thanks for posting this.

I was going to ask about chemical castration, but you posted this earlier.

As far as I know, androcur is over the counter in Russia, so here is the only remaining question - you listed memory loss in side effects - can you give any more details on this?

Interesting stuff.

Ideally Lupron should be for chemical castration, but as you mention the cost usually prohibits it, especially since many insurance companies will not cover it, and the few that will have a very narrow set of conditions they will cover it for. I know someone who believes his insurance will cover Lupron under "depression." Keep dreaming, I tell him Without insurance it usually runs about 500 to several thousand dollars per month, depending on dose.

40 mg of injectable estrogen every other week is double the normal recommended dose for transition, which is 20 mg on the same schedule. However, some will need more, depending on personal response.

I would personally not recommend the use of depo-provera as a progesteronic agent. The need for progesterone in transition is controversial (I believe a large part if not all of that controversy is because progestins like depo-provera are usually used rather than real progesterone). Progestins are not real progesterone. They exhibit some progesteronic effects in the body, but not all (increased breast development may or may not be one of the effects progestins induce, most likely not in light of the controversy), but they may also exhibit some harmful effects that real progesterone does not (such as adverse lipid profile effects). My recommendation would either be Prometrium or a compounded bio-identical progesterone.

Some doctors are indeed using concurrent oral administration of estrogen along with the shots because it may help prevent levels from getting too low in between shots.

The Motilium thing is especially interesting. I knew about the lactation effect, but I had never heard that it causes increased breast development. Could you share where you got this information?

On 4 mg sublingual estrogen daily divided into two equal doses, my levels were 118 pg/ml. A bit on the low side, although they could produce feminization over time the same way higher levels would in a shorter period.

KoiMochi,

I would strongly suggest you speak with a gender therapist before you go any further. You need to know what exactly your desires are and what is causing them. You don't want to do something irreversible to your body and then discover it is not what you wanted after all That being said, not all respond to medications or even low T levels in the same way. Some are still able to maintain libido and function with no T and even E.

fhunter,

I used to have an excellent memory. Since castration, it isn't so great anymore. Still good, but not the top notch memory it used to be. I am finding myself forgetting things that are said to me a short time later, and seeing people do things and forgetting just a few minutes later that they have done them. The same goes for directions. I used to be the best person I and those around me knew to ask for directions somewhere. I'd go somewhere once and remember exactly how to get there, and all street names associated with getting there. Now I need to see a place several times, and I still don't remember 100% how to get there or the street names.

thanks plix, i have heard from doctors who recommend anywhere between 20 to 70mg of depot estrogen, 40mg creates a "late-puberty" level of estrogen which causes more rapid feminizing. The dosages of corse should be tailored to the persons tolerance and needs.

Prolactin raising is something that was discussed in some of my classes, ive also read a few protocols that this was used in. Prolactin, of coarse, causes tissue growth in preparation of lactation, and then starts it. Unless one is pumping it wont let down and start production at significant levels.

There are about as many protocols as there are doctors, this more or less is an average of what i have witnessed.

Humm... I might add my current regimen im going under, Eunuch 2 Male.. lol..

My experience - on Androcur at VERY low T levels 2mg of estrogen SLOWLY creates breast tissue - 4mg (in my body) did it QUITE fast, couple of months...

4mg was also a moody time for me - very moody!! Cry at movies, cry at everything!

Estrogen is not to be taken lightly, you have the potential for stroke - but there are TG friendly doctors that will do the blood work - they won't be happy about it if you are not prescribed E - but they will do them.

2mg is sufficient for a mellow mood change, 4mg gets a bit drastic (In my body) - although I enjoyed 4mg it was a bit much.

Just my thoughts, please be careful when taking estrogen!

When I go get more blood tests done I'll go back on estrogen - it's mentally POWERFULLY addictive in that you will experience a calm like never before - more than just blocking T....it's harder to quit than smoking is.

im going to revise the E dosage according to weight and tolerance, there are sooooo many protocols and combos..

and yes, its addictive, i was on E for a year at 20mg bi-weekly and i really miss it, but i think i like T better...

Tclosetgirl (imported) wrote: Tue Oct 16, 2007 8:29 pm My experience - on Androcur at VERY low T levels 2mg of estrogen SLOWLY creates breast tissue - 4mg (in my body) did it QUITE fast, couple of months...

4mg was also a moody time for me - very moody!! Cry at movies, cry at everything!

Estrogen is not to be taken lightly, you have the potential for stroke - but there are TG friendly doctors that will do the blood work - they won't be happy about it if you are not prescribed E - but they will do them.

2mg is sufficient for a mellow mood change, 4mg gets a bit drastic (In my body) - although I enjoyed 4mg it was a bit much.

Just my thoughts, please be careful when taking estrogen!

When I go get more blood tests done I'll go back on estrogen - it's mentally POWERFULLY addictive in that you will experience a calm like never before - more than just blocking T....it's harder to quit than smoking is.

Was the 4 mg all at once or split into multiple doses?