Can anyone tell me the difference between an anti-androgen like androcur or spironolactone and a progestin such as depo provera? I'm hoping to start some kind of regimine on my birthday later this month.

I found some info in transgender care

http://www.transgendercare.com/medical/ ... gimens.asp

Progestins

Medroxyprogesterone

Medroxyprogesterone 5 to 10 mg daily, 10 days of the month. Medroxyprogesterone is a progestin, that being an synthetic form of the naturally occurring progesterone. Taken cyclically in a relatively small dose, this progestin is considered by some to have the potential to promote breast development in individuals. Medroxyprogesterone is usually supplied in micronized tablet form, so it can be taken sublingually. Occasionally mild depression is seen in individuals taking progestins, so this drug should be discontinued if there are any adverse effects that cannot be readily attributed to other factors. An alternative is progesterone, but it is not as readily available.

http://www.inhousepharmacy.com/transgen ... ender.html

Dydrogesterone) may be used as an alternative to medroxyprogesterone acetate. It is not metabolised into testosterone within the body, and is therefore free of the virilising effects which some patients experience ftom other progesterones. A typical pre-op (or early post-op) dose would be 20mg in two doses, reducing to a single dose of 10mg daily post-op.

Dydrogesterone – Duphaston

This progestogen (trade name Duphaston) may be used as an alternative to medroxyprogesterone acetate. It is not metabolised into testosterone within the body, and is therefore ftee of the virilising effects which some patients experience ftom other progesterones. Conversely it may be less effective in maintaining libido than medroxyprogesterone acetate. Dydrogesterone is regarded as the progestogen of choice when patients have experienced virilising effects from other progestogens. A typical pre-op (or early post-op) dose would be 20mg in two doses, reducing to a single dose of 10mg daily post-op

Then i found a bit of side info on how Medroxyprogesterone binds to the andro receptors..

Medroxyprogesterone acetate does not convert/metabolize to

testosterone. However, it binds and ACTIVATES androgen receptors much

like testosterone, thus exerting androgenic effects at the receptor

level.

Umm.. I hope the info helps

http://en.wikipedia.org/wiki/Hormone_re ... 28trans%29

This has a very good description of the differences between those substances. Thanks to Fami for sending me this link.

I guess where I'm gettin confused is that I've read that people have used Depo-Provera for chemical castration yet when I look up information about it, its listed as an progestin which doesn't seem to say anything about anti-testosterone effects.

From what I've read on here Depo-Provera seems like the drug I'd like to take for chemical castration purposes but I can't seem to to find any information about it's effects on other sites.

If I wanted to go a step further and experience some feminization, would I have to take all three types of hormones or just Depo & an estrogen supplement?

Well inhouse pharmacy has depo provera listed as a weak antiandrogen.

fami (imported) wrote: Tue Mar 06, 2007 10:49 pm http://www.inhousepharmacy.com/transgen ... ender.html

Medroxyprogesterone is available as Provera and Depo-Provera. Medroxyprogesterone is a weak antiandrogen, and testosterone suppression may be accomplished with lower doses of estrogen. Medroxyprogesterone is less androgenic than norethindrone and orgestrel.

fami (imported) wrote: Tue Mar 06, 2007 10:49 pm http://www.inhousepharmacy.com/transgender/

depo-provera-t.html

Progestogens are usually given in an attempt to improve breast development. Progestogens can also inhibit testosterone, and are sometimes used for this purpose. Medroxyprogesterone, the most commonly used product, has the disadvantage of counteracting some of the beneficial effects of estrogen on blood lipids. Micronized ("natural") progesterone is sometimes suggested as an alternative, but it is expensive, sometimes hard to find, and difficult to obtain without prescription.

Though Medroxyprogesterone binds and activates

fami (imported) wrote: Tue Mar 06, 2007 10:49 pm androgen receptors much

like testosterone, thus exerting androgenic effects at the receptor

level.

I take 1 shot of depo provera every 30 days and it seems to have lowered my sex drive noticeably ^^; Don't know about Ts and what not. I think Progestogens are mainly use to improve breast growth.

I actually want to try androcur I was recommended a dosage of 12.5mg per day, pills would have to be cut in to four pieces. Androcur is expensive but once you realize that each pilll wil be used as four.. the cost noticeably "Drops".

I've looked at androcur but I've heard that it's pretty rough on the liver and considering that i'm a moderate to heavy drinker I probably don't need to be putting any extra strain on it.

Jaiden (imported) wrote: Wed Mar 07, 2007 8:23 pm I've looked at androcur but I've heard that it's pretty rough on the liver and considering that i'm a moderate to heavy drinker I probably don't need to be putting any extra strain on it.

I have been on Depo-Provera for 7 months now and have experienced no side effects such as mood swings or tiredness/fatigue. No weight gain either. I just no longer have a sex drive and am quite happy about that.

Studlover