Point of curiosity that arose today in a discussion with someone about anti-androgen chemicals.

Folks here use a number of different chemicals to effect castration without surgery, such as spiro, depo provera, adnrocur, and so on.

What is the method of the function of the various chemicals. In particular, do any of these act directly as an antagonist to Testosterone - i.e., disabling it? Or do they function by disrupting the signalling process, telling testosterone production to shut down? My conversant is especially interested to know about any drug that is directly antagonist to T.

There are a number of folks here who are quite knowledgable about hormones. Perhaps one of several could respond?

Thanks

Think this link will help on androcur.

http://www.inhousedrugstore.com/bcp-hor ... ation.html

Depo

http://www.inhousedrugstore.com/transge ... ation.html

Spironolactone

http://www.inhousedrugstore.com/transge ... cians.html

From what I read, thus far, none of these chemicals is an anti-androgen, but rather, at best, an androgen-site receptor blocker; thus not an androgen agonist. Blocks effect, not the androgen....

I was placed on spironolactone 200 mg daily in divided doses and Estraderm TTS 25mcg. Though I think the estraderm patch content is really low.. I know I must be placed on a low dosage to start with but I just can't wait lol.

I was wondering what the average patch dosage is once you get past this "Plateau". I read that Estraderm TTS 25mcg should be administered only to patients who cannot tolerate the higher dosage. So it seems weak.

I have also read that some patients are given two 0.1 mg patches to be applied simultaneously This all just seems completly confusing to me Could someone explain why this is done lol.