Wonder if it works on boys?

BW5355 MAY 19,2003 9:00 PACIFIC 12:00 EASTERN

( BW)(MO-NEUTERSOL/ABL) First Neutering Drug for Puppies Gains FDA Approval

Business Editors/Pet Care & Veterinary Writers

COLUMBIA, Mo.--(BUSINESS WIRE)--May 19, 2003--

Neutersol(R) (Zinc Gluconate Neutralized by Arginine) Is First

Approved Non-Surgical, Injectable Sterilant for Safe, Effective

Neutering of Male Puppies Ages 3 to 10 Months

Puppy owners will now be offered a choice for neutering their male puppies. The federal Food and Drug Administration has approved Neutersol(R) (Zinc Gluconate Neutralized by Arginine) as the world's first injectable neutering drug for puppies 3 to 10 months of age.

Procedure Is Brief

With the puppy lying on its back and properly restrained (chemical restraint may be used, if necessary, to prevent the dog from moving during the injection), the veterinarian gently injects Neutersol into each of the testicles using a very fine needle. The exact dose is pre-calibrated by measuring the width of the puppy's testicles using a custom dosing caliper. Neutersol is 99.6% effective in achieving sterilization.

Benefits Prompt Immediate Understanding of Choice

Owners are relieved of their worries of subjecting the puppy to surgery and the time it takes, thus providing an attractive choice. "When presented with the time savings, speed and ease of the Neutersol procedure, owners immediately understand the advantages of choosing Neutersol as the neutering approach," notes Jim Howard, D.V.M., owner of Howard Veterinary Hospital in Jefferson City, Mo., one of the five test sites for the neutering product. "They now have a choice between surgery or an injection that takes only a few minutes."

Study Findings

Neutersol (Zinc Gluconate Neutralized by Arginine) for pharmaceutical sterilization of 3-to-10-month-old male dogs was developed by the late Dr. Mostafa S. Fahim, Director of the Center of Reproductive Science and Technology, School of Medicine, University of Missouri-Columbia. The research and development of Neutersol and other technology was conducted by Dr. Fahim and his staff and was sponsored by Technology Transfer, Inc. (a Missouri corporation) since 1990. The long process of obtaining FDA approval of Neutersol began in 1991, and Technology Transfer, Inc. licensed Addison Biological Laboratory, Inc. to market Neutersol after receiving FDA approval.

Pilot, dose determination, and target animal safety studies were completed prior to the field study that was conducted at five test sites throughout the U.S. The test sites enrolled 270 puppies, ages 3 to 10 months, according to pre-determined protocols involving testicle widths and good general testicular health. Post-injection, the participating puppies were monitored for general attitude, appetite, ability to walk, scrotal pain on testes manipulation, rectal temperature, and general scrotum description. Complete physical exams were conducted at three days, two months, and six months post-injection. Of the 224 dogs that completed the study, 223 (99.6%) were permanently sterile. Mild, temporary swelling of the testicles is an expected reaction to the injection noticed within 24-48 hours after injection. Other possible side effects include vomiting, anorexia, lethargy, diarrhea, scrotal pain, and scrotal inflammation.

Min Wang, M.D., Senior Research Associate, Center of Reproductive Science and Technology, School of Medicine, University of Missouri-Columbia, conducted the study and presented the field trial findings in "Neutersol: Intratesticular Injection Induces Sterility In Dogs" at the April 2002 International Symposium of Non-Surgical Methods for Pet Population Control. See www.neutersol.com/fieldstudy for detailed study protocols and report of findings.

For more information about Neutersol, contact your local veterinarian.

About Addison Biological Laboratory, Inc.

Addison Biological Laboratory, Inc., Fayette, Missouri, is the exclusive marketer of Neutersol. Addison is a privately held company that improves the lives of animals through its variety of animal health products and diagnostic services used by veterinarians worldwide. The company is widely known for its Maxi/Guard(R) line of proprietary vaccines and small animal products for dermatology, otology, and veterinary dentistry. For further company information, visit http://www.addisonlabs.com/.

--30--TM/la*

CONTACT: For Neutersol/ABL

Betsy Myers, 310/275-4608

[email protected]

KEYWORD: MISSOURI

INDUSTRY KEYWORD: MEDICAL CONSUMER/HOUSEHOLD PRODUCT

SOURCE: Neutersol/ABL

What do you think? really now, come on.



It sounds great if you are a puppy between 3 and 10 months old

I think i would probley take the experance of Scottie and i probley never inject anything like that in my testicles.Dogs are not the same as people.

Well said, Sag_111

How many times do you clean out the fridge and throw the questionable goodies to the dog? And the dog eats them, and goes on happily without so much as a burp! Things that would probably make a human very sick - or at least quite miserable - don't even effect dogs.

Also, a human would have much more mass to a testicle than a little puppy would. You can't just snitch some of this stuff from the vet and think it's going to work. The shot for a puppy would probably do nothing but cause some irritation to a fully grown human testicle. STILL, we don't want to find out.

Remember all the suffering Scottie got into with his experiment. All fantasy aside, folks, injections of WHATEVER into a testicle is a dangerous thing. Please be careful out there.