I seek answers from other patients and medical doctors to the question: Is Femarelle/Tofupill helpful as substitute for HRT to remediate menopause-like symptoms after castration, with fewer adverse effects. And, what is the best site to buy Femarelle from on the Internet for best price and quality?

Here is my writing to endocrinologist (Rohit Jain MD, whom I already had a consult - he said he can prescribe degarelix, but not Femarelle) for comment by anyone, particularly Dr. Irwig:

I am seeking to abolish most of my androgens so as to reduce androgenic hair and physical masculinity, to reach a castrate-like physical state that matches my somatic idea. Androgen hormones in my body now are not appropriate for this somatic idea – hyperandrogenism. After reading more by the castrates of old I have come to think that is the right body for me. I wish to have a smooth hairless body and not have masculine sexuality and libido. My wish is to set my hormones to what they were when I was 10 years old. These wishes have been persistent, consistent, and insistent for more than twelve years, and have been affirmed by two psychologists (Shawn Rubin PsyD and Ann Clawson PhD), who have recommended appropriate action to correct my hormones.

For years I have thought of all possible medications to temporary simulate castration so that I know what my body is like without androgen hormones. I would not have a medication that has adverse effects separate from the antiandrogen effect, so that I would not confuse that with not liking the effect of castration. Spironolactone, in exemplo, is a diuretic, separate from antiandrogen effect. I had an idea to combine spironolactone mid glycyrrhizin (that is an antiandrogen too and opposes the diuretic effect of spironolactone). However this would need the right combination of doses so that the diuretic and anti-diuretic effects are neutral.

Now, I have reached the conclusion that degarelix, FDA approved medication for prostate cancer, is the best medication to temporary simulate castration without extraneous adverse effects. It is given by subcutaneous injection (like insulin) once in 28 days.

I will have a phyto-estrogen supplement like Tofupill/Femarelle (Recharge that has the highest dose of the flaxseed extract) to prevent and remediate menopause-like symptoms, like hot flashes, that I may suffer after castration (whether by injection or orchiectomy). Is Femarelle the best or is something else similar more effective? I need something plant-based that has fewer adverse effects (like thrombosis or cramps) than synthetic estrogen or SERM. CAN YOU GIVE ME A PRESCRIPTION FOR FEMARELLE OR SOMETHING SIMILAR IN ADDITION TO THE DEGARELIX? I think best to have the Femarelle before first castration injection to prevent adverse effects that might upset me.

In response to warnings from medical doctors that I may lose bone without any sex hormones, I have a question I sought to learn answers for: “What hormones stimulate the increment in skeletal bone mass (ossification) before puberty?”.

Calcitonin and somatotropin are two hormones that stimulate osteoblasts to generate new bone and inhibit osteoclasts that cause bone loss. Calcitonin is stimulated by intravenous calcium infusions or by sufficient ample oral calcium doses. Enteric calcium absorption is augmented by simultaneous oral dose of vitamin C, (milk) lactoproteins, eggshell proteins, and/or one of three swift-acting prescription “vitamin D” agents: calcitriol, paricalcitol, or dihydrotachysterol. (Non-prescription “vitamin D” supplements are not so effective for that it is dependent on metabolic activation in liver and kidneys, and by that time it has spread through the whole body, and under some conditions may in fact stimulate osteoclasts that cause more bone loss. These three prescription “vitamin D” agents are better (mid simultaneous oral calcium dose) for immediate action to stimulate calcium absorption in the intestine, and have less persistent effect on other parts of the body.) In reaction to more calcium absorbed into body fluids, the thyroid generates calcitonin to preserve homeostasis, and that stimulates osteoblast to generate new bone. Exogenous calcitonin may be given by subcutaneous injection, however effect may be limited without simultaneous dose of calcium for that it causes a deficit of calcium in body fluids that then stimulates an opposite homeostatic reaction from the parathyroid.

Somatotropin stimulates osteoblasts to generate new bone, too. Among many other things, somatotropin is stimulated by the sex hormones (androgen and estrogen). This may be part of the cause why castrates are more likely to lose muscle and bone. However somatotropin is stimulated by various nutrients and supplements, and physical activity. Exogenous somatotropin can be given by subcutaneous injection.

Important to know that I have ample calcium from milk and vegetarian milk substitutes, in addition to 160 mg every day from supplements – at least 1100-1200mg per diem mediatum per annum. I never eat unhealthy foods or drinks that cause calcium depletion. I also insume magnesium and vitamin C supplements. I read this article by more supplements to prevent osteoporosis: https://www.lifeextension.com/protocols ... teoporosis.

After castration, I will be more willing to have more supplements (including lipid-soluble vitamins, Zinc/Cu) that I am reluctant to have now for fear that these may increase androgens. Castration will help my physical and mental health overall. I wish to consult for the best supplements to maximise my physical and mental health after castration.

One thread, one subject, ONE forum, please.

Thank you.

I take vitamin D3 and.a calcium pill. That's all my doctor says I need. I also try to eat healthy with varying degrees of success.