Orchiectomy in the Primary Therapy of Patients with Bone Metastasis in Advanced Prostate Cancer

Discusses plain-old orchiectomy in treatment of Prostate Cancer.

Interesting only in that it describes basic treatment and recovery times.

JoeGreenParadox (imported) wrote: Thu Sep 07, 2023 5:40 pm Orchiectomy in the Primary Therapy of Patients with Bone Metastasis in Advanced Prostate Cancer

Discusses plain-old orchiectomy in treatment of Prostate Cancer.

Interesting only in that it describes basic treatment and recovery times.

Thanks for posting about this, but it is more helpful if you can include links to the actual article not just a title... Better yet is to include a copy of the actual article, or at least the abstract.

WheelyCurious

Please excuse me. Below is what I meant to post.

Link and abstract

Subcapsular

JoeGreenParadox (imported) wrote: Thu Sep 07, 2023 5:40 pm Orchiectomy in the Primary Therapy of Patients with Bone Metastasis in Advanced Prostate Cancer:

An Anachronistic Intervention?

https://pubmed.ncbi.nlm.nih.gov/21922019/

National Institutes of Health (.gov)

https://www.ncbi.nlm.nih.gov › articles › PMC3172971

Oleg Rud 1 , Julia Peter, Reza Kheyri, Christian Gilfrich, Ali M Ahmed, Wieland Boeckmann, Paul G Fabricius, Matthias May

Affiliations

PMID: 21922019 PMCID: PMC3172971 DOI: 10.1155/2012/190624

Abstract

Background. The therapeutic impact of palliative androgen deprivation in metastatic prostate cancer is indisputable. Bilateral orchiectomy represents the traditional method of AD but was reduced during the last years in favor for treatment with LHRH analogues. Due to limited economic resources of the health care system, the economically priced definite surgical castration might experience a renaissance. Methods. In this single-center retrospective study, 83 consecutive patients with osseous metastasized prostate cancer were evaluated, who had primarily been treated by subcapsular bilateral orchiectomy. Response to therapy, time until therapy failure, overall survival time, psychological disorders due to loss of organ, and disease-associated and postoperative surgical complications were recorded. The median followup was 35 months (IQR: 26-46). Results. Patients' mean age at surgery was 72.1 (54-91) years. Six patients (7.2%) displayed immediate tumor progression after orchiectomy. Median time of tumor remission and overall survival time were 29 and 36 months, respectively. 14% of the study group showed minor postoperative complications. No psychological problems occurred following bilateral orchiectomy. Conclusion. Due to an effective and persistent oncological effectiveness, less morbidity, and absence of psychological implications, bilateral subcapsular orchiectomy seems to be a practicable and advisable alternative in the first-line therapy of metastasized PCa. Subcapsular orchiectomy in the primary therapy of patients with bone metastasis in advanced prostate cancer: an anachronistic intervention?

Oleg Rud 1 , Julia Peter, Reza Kheyri, Christian Gilfrich, Ali M Ahmed, Wieland Boeckmann, Paul G Fabricius, Matthias May

Thanks for the abstract, it really helps to have that so we can see what papers are about.

WheelyCurious

The article is talking about "subcapsular orchiectomy," where only the glandular tissue lining the testicles is removed, leaving the testicles in place.