Hi,

I've reviewed many of the threads here and I plan to continue doing so. But there's no dedicated FAQ page to my knowledge so everything's scattered. If you guys could shed some light on any of these I'd most welcome that.

1. Aside from inhibiting gynecomastia, does tamoxifen/raloxifene (I'm aware they are two different drugs) actually reverse it so far as it's already happened? Does it also prevent gendered changes in fat distribution patterns?

2. Does E reverse the mental decline brought on by castration?

3. Does tamoxifen/raloxifene, so far as it inhibits physiological feminization, also block the effects of E on the brain and mood?

4. Is it safe to take the obligatory SERMs, Estrogen, and AA drugs all at the same time (assuming normal or roughly normal doses of each)? The users here have referenced being on two of these at once, but I've yet to see anyone mention being on three at once.

5. I've seen users reference taking drugs like Spiro or Androcur at doses of 200mg. In the case of Spiro the latter is referred to as a high dosage. By this do they mean two 100mg doses or two 200mg doses? I would assume the former, right?

6. I'd like to arrange to visit a urologist on the 27th and it looks like that might happen. As a 23 year old man what are the main tests I should undergo before starting a trial run? About how expensive would it be to afford these tests out of pocket? As I do not have unlimited funds are all of them strictly necessary to ensure my safety? If you could recommend just one, two or three, what would they be?

I am not a doctor, so these are my opinions only based on my own experience.

1. I have no experience with these drugs.

2. In my experience, yes it does.

3. Again, no experience.

4. No experience with SERMS, but I’ve heard of a lot of people doing this. I did take AA (Spironolactone) for a while before I started Estrogen. And my experience is that you don't want to be on Spiro long term.

5. I was on Spiro at 200mg day. One 100mg pill in AM and one in PM.

From; https://transcare.ucsf.edu/guidelines/f ... ne-therapy

References a max of 200mg per day.

6. I cannot give you any references as to price of blood tests. But I would recommend that you have done what the doctor needs. He needs all the info he can get to make sure you’re healthy enough and without any underlying conditions which may inhibit the process. Just make sure that the doctor you are seeing has some experience with transgender people. Because basically you are asking for the same medicines and chemicals that trans women use.

I know I didn't answer all your questions, but hopefully have given you some relevant information. Others will also post of their experiences. I wish you all the best in your journey. Keep us informed.