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Permanent testicle damage caused by HRT

Posted: Sun Nov 10, 2019 1:48 pm
by twisted.reality (imported)
Hello,

I am a MTF transgirl. I have been on HRT for 17 months. I have always been on estradiol monotherapy (pills for 12 months, now injectable for 5 months). I have experienced some testicle shrinkage.

I would like to ask if someone has experience with shrinkage staying permanent even after stopping hormones (any hormones count, estradiol, testosterone, SARMs, cyproterone a., because all of them have the same effect on testicles). I know that it is generally said that chemical castration is not permanent but I keep reading stories of steroid users, who have to be on lifetime TRT because their natural production is gone.

I need to know because I am DIY and do not plan to start any official therapy. However I want the testicles gone and my idea is stopping hrt, going to urologist where they discover shrinkage and zero T production and this would grant me the golden removal ticket.

Re: Permanent testicle damage caused by HRT

Posted: Sun Nov 10, 2019 2:24 pm
by sparkey49 (imported)
Have you consider injecting that is how I got rid of mine.

Re: Permanent testicle damage caused by HRT

Posted: Sun Nov 10, 2019 2:44 pm
by twisted.reality (imported)
sparkey49 (imported) wrote: Sun Nov 10, 2019 2:24 pm Have you consider injecting that is how I got rid of mine.

I did, I got the strongest alcohol possible (pure alcohol 80%/160 proof) but I freaked out with a syringe in my hands and haven't done it yet. In fact there are more reasons. They have really become smaller, lumps have appeared and they often hurt. And I don't want to rush into ER. However this option is being considered, I want to make it as easy as possible and I want to be sure that I will get (lose) what I want.

Re: Permanent testicle damage caused by HRT

Posted: Sun Nov 10, 2019 5:52 pm
by Chesleyt (imported)
If you have any lumps you should immediately see a doctor it could be cancer that how it starts I would be very afraid.

Re: Permanent testicle damage caused by HRT

Posted: Sun Nov 10, 2019 7:17 pm
by Stevenator (imported)
Just take Tagamet .... I’m not sure what the final results would be, though. Although I’m unsure it will kill them gone, Tagamet (Cimetidine) will significantly reduce the size of your testicles & penis. This much I can confirm. About six weeks ago I was looking for OTC meds that cause Gynecomastia. Although I’m a male staying & presenting as a male, for the last four years I’ve been practicing Natural Breast Enlargement, primarily using Pueraria Mirifica as my phytoestrogen source. I’ve attained a B-cup, but I naturally want more. I happened upon a study showing that a 1,000mg a day dose for Cimetidine’s intended use for severe acid attacks also releases a flood of prolactin. As my prolactin source is usially Fenugreek & Shatavari, I was looking for another option. After three days I noticed fuller breasts from the prolactin. I also noticed a markedly reduction in penis & testicle size. This was an unwanted effect for me. They shrank a good 1/2 size smaller. While nearly four years of phytoestrogens had already shrank my once fat cock, seeing the accelerated shrinking in just three days was a shock to me. That was six weeks ago, and I have not recovered any former size. Looking into this yesterday I was looking for a way to share this info on this forum, so I’ll add the links here. Cimetidine completely blocks DHT receptors. I was unaware of this. I guess that, along with the flood of prolactin caused the nice boost in boobie growth. I was unaware how it also attacks the testicles. Several study participants noted in the published findings report permanently smaller testicles and penis. Some claim the Testicle Leydig Cells are permanently affected, meaning cell death. Leydig’s produce sperm. I did read one hypothesis that they’re just folded over. But study after study shows a relatively high dose always shrinks the testicles. A basic understanding of medical jargon is helpful when reading these studies. Or you can just google the odd words to find their meanings. Erections now are exceedingly difficult. Ejaculation is just as difficult. Orgasm is intense in a subtle way, and semen is very concentrated and practically non existent. I’m personally of the mindset that our balls are a lot more resilient than we give them credit, as per the multiple attempts via injections are reported here. That’s just my basic understanding of the threads I’ve read, never trying it myself. Also I’ve been an extreme CBT aficionado over the years and they were always fine and never worse for wear. But, that being said, I sit here with nuts 1/2 of their original size. My penis is tiny compared to what it used to be, with no real indication that will change. From just 3,000mg over just three days!!?!! Having realized this is most likely never going to recover, with a continued interest in the extreme effects it has on hormonal function, blocking DHT, producing a flood of prolactin, and tbh, embracing the new me, I just ordered 120 more tablets of Tagamet (Cimetidine). For all intents and purposes, I’ve appeared to happen upon another option for chemical castration that appears will be somewhat permanent. Tbh, I’m really surprised that this stuff is otc legal.

Happy Reading!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040935/

https://www.spandidos-publications.com/etm/15/6/4643

https://academic.oup.com/biolreprod/art ... 03/2723409

https://www.sciencedirect.com/science/a ... via%3Dihub

https://www.gastrojournal.org/article/S ... 0217-6/pdf

Re: Permanent testicle damage caused by HRT

Posted: Sun Nov 10, 2019 11:35 pm
by twisted.reality (imported)
Chesleyt (imported) wrote: Sun Nov 10, 2019 5:52 pm If you have any lumps you should immediately see a doctor it could be cancer that how it starts I would be very afraid.

That would work too for my intentions. I can't say cancer would make me happy. If I decide for a visit I will have to stop hrt, which for me is the worst part.

Re: Permanent testicle damage caused by HRT

Posted: Sun Nov 10, 2019 11:40 pm
by twisted.reality (imported)
Stevenator (imported) wrote: Sun Nov 10, 2019 7:17 pm Just take Tagamet .... I’m not sure what the final results would be, though. Although I’m unsure it will kill them gone, Tagamet (Cimetidine) will significantly reduce the size of your testicles & penis. This much I can confirm. About six weeks ago I was looking for OTC meds that cause Gynecomastia. Although I’m a male staying & presenting as a male, for the last four years I’ve been practicing Natural Breast Enlargement, primarily using Pueraria Mirifica as my phytoestrogen source. I’ve attained a B-cup, but I naturally want more. I happened upon a study showing that a 1,000mg a day dose for Cimetidine’s intended use for severe acid attacks also releases a flood of prolactin. As my prolactin source is usially Fenugreek & Shatavari, I was looking for another option. After three days I noticed fuller breasts from the prolactin. I also noticed a markedly reduction in penis & testicle size. This was an unwanted effect for me. They shrank a good 1/2 size smaller. While nearly four years of phytoestrogens had already shrank my once fat cock, seeing the accelerated shrinking in just three days was a shock to me. That was six weeks ago, and I have not recovered any former size. Looking into this yesterday I was looking for a way to share this info on this forum, so I’ll add the links here. Cimetidine completely blocks DHT receptors. I was unaware of this. I guess that, along with the flood of prolactin caused the nice boost in boobie growth. I was unaware how it also attacks the testicles. Several study participants noted in the published findings report permanently smaller testicles and penis. Some claim the Testicle Leydig Cells are permanently affected, meaning cell death. Leydig’s produce sperm. I did read one hypothesis that they’re just folded over. But study after study shows a relatively high dose always shrinks the testicles. A basic understanding of medical jargon is helpful when reading these studies. Or you can just google the odd words to find their meanings. Erections now are exceedingly difficult. Ejaculation is just as difficult. Orgasm is intense in a subtle way, and semen is very concentrated and practically non existent. I’m personally of the mindset that our balls are a lot more resilient than we give them credit, as per the multiple attempts via injections are reported here. That’s just my basic understanding of the threads I’ve read, never trying it myself. Also I’ve been an extreme CBT aficionado over the years and they were always fine and never worse for wear. But, that being said, I sit here with nuts 1/2 of their original size. My penis is tiny compared to what it used to be, with no real indication that will change. From just 3,000mg over just three days!!?!! Having realized this is most likely never going to recover, with a continued interest in the extreme effects it has on hormonal function, blocking DHT, producing a flood of prolactin, and tbh, embracing the new me, I just ordered 120 more tablets of Tagamet (Cimetidine). For all intents and purposes, I’ve appeared to happen upon another option for chemical castration that appears will be somewhat permanent. Tbh, I’m really surprised that this stuff is otc legal.

Happy Reading!

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040935/

https://www.spandidos-publications.com/etm/15/6/4643

https://academic.oup.com/biolreprod/art ... 03/2723409

https://www.sciencedirect.com/science/a ... via%3Dihub

https://www.gastrojournal.org/article/S ... 0217-6/pdf

Thank you, this is interesting but it seems that it can only be bought in th US, prescribed probably in the UK. I am in the EU Czechia and this drug is not available at all (and customs don't let even herbal extracts in the country). I will find out more and this goes on my list of options.

Re: Permanent testicle damage caused by HRT

Posted: Tue Nov 12, 2019 12:44 pm
by Sojourner (imported)
Stevenator

Thx for the interesting articles on Cimetidine.

Are you purchasing 1,000mg tablets or just taking

multiple 200mg per day and anywhere special for a good price?

Re: Permanent testicle damage caused by HRT

Posted: Tue Nov 12, 2019 1:14 pm
by Stevenator (imported)
Thanks. I thought this board might find this information interesting. I took Walmart brand generic Cimetidine. It’s about $5 in the store. It’s also available on Amazon for a little more. I bought the bottle over a year ago and noticed the effect and quit. I took it for several days and quit. I didn’t like the immediate effect of five 200mg a day for a total of 1,000mg. Fast Fwd to this year when I decided to try it again, because at the time I was out of my NBE Herbs. I noticed the immediate effect of dramatic penis & testicles shrinkage and I got a little concerned and I quit again. This time the reduction in size was much more than before, so I did more research and saw *why* it induces Gynecomastia, was the effect it has on the testicles. I believe that this year I’ve had another 12-18 months or so of assaulting my endocrine system that I believe the balance was easier to tip, meaning I’ve been taking phytoestrogens for over a year more to tamp down testosterone to an even lower level. I’m curious about the (long term) affect, so needless to say I ordered 120 more capsules. This dramatic shrinkage was only three days of dosing. After six weeks I’ve yet to recover any size, and I’m starting to get attached to the new mini-me. It’s actually a lot of fun. Granted, sexual activity is extremely difficult, but it looks and feels great. I’m curious to what extent that testicular apoptosis will occur, as I plan on dosing for 12 days, taking a break to cleanse & evaluate, and possibly dosing for 12 more days. There are tons more studies available online. I just added these here. Alter internet search words for a full spectrum of articles.

Re: Permanent testicle damage caused by HRT

Posted: Tue Nov 26, 2019 12:52 am
by Stevenator (imported)
It’s been two months since my 3-day experiment with Tagamet, (Cimetidine), and I still have not recovered Testicle or Penis size. I’m still extremely small. While, I did discontinue Tagamet, (because of the small supply), I did continue with my NBE Herbs. I’ve been hammering my endocrine system for the last four years. I believe it didn’t take much Tagamet to do the damage. I did order 120 more capsules, as I was determined to see if I could permanently induce Testicle apoptosis, I got a failure in delivery notice from the supplier, so I took it for a sign. Knowing it’s available at Walmart is a struggle, though I’ll admit searching for it at other stores. Erections are still exceedingly difficult. If I don’t see any improvements in _____ months, then I will consider trying again. Mainly for the flood of prolactin that if provides, as was my original intent. All initial searches for OTC Drugs that caused Gynecomastia, had articles about Tagamet triggers prolactin in men. I didn’t realize it also literally kills your testicles, too. I’m still intrigued, I’ll admit. It’s odd having a tiny cock & balls now, when I used to have a huge cock & huge balls. But, I’m kinda attracted to the little fellas, I might add.