https://www.cbsnews.com/news/researcher ... ntrol-gel/
Researchers testing potential breakthrough for male birth control gel CBS News November 29, 2018, 7:18 PM
2 minutes
NEW YORK This week the National Institutes of Health (NIH) announced the start of a trial for a male contraceptive in gel form. It's a big step in the search for a birth control men can use, and if it works, it would fill an important public health need.
According to the NIH, the gel called NES/T, contains a form of progestin, a hormone that can prevent ovulation during pregnancy. It blocks natural testosterone, reducing sperm production. The gel also contains replacement testosterone to maintain normal sex drive and other functions.
It's applied to the back and shoulders daily and is absorbed through the skin. Researchers will study around 420 couples for about a year to see if the gel is effective in preventing pregnancy. But CBS News medical contributor Dr. Tara Narula said it won't be available for use right away. Since it's a first trial, more research will be needed down the road.
"For any product like this to move forward, it's going to have to be safe, effective and reversible," Narula said.
Right now, there's no male birth control pill available. Narula said one reason is because a lot of the research has been left to non-profits and governments. Another issue comes down to biology.
"It's much harder to repress the production of hundreds of millions of sperm that are produced every day versus one to two eggs produced every month," Dr. Narula said. "But researchers are saying look, it's time for gender equity right now. We need to have more shared responsibility in family planning."
Researchers studying effectiveness of male birth-control gel
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Wolf-Pup (imported)
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TopManFL (imported)
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Re: Researchers studying effectiveness of male birth-control gel
Tamsulosin (brand name Flomax) has been studied as a possible male birth control.
It's FDA approved for use in the treatment of symptoms of enlarged prostate.
It works by relaxing smooth muscles in the groin. One of its side effects is that during orgasm the muscles that normally contract to divert the flow of semen during ejaculation fail to contract.
The result is anejaculation (the semen flows into the bladder and not out of the penis).
Oddly, when Flomax went generic the money to fund the studies for its use as a male contraceptive dried up.
The United States National Institute of Health ( NIH / CDC ) has an article on the studies that were preformed.
https://www.ncbi.nlm.nih.gov/pubmed/22840866
(I'm including the text as it's listed on a Government website, but be aware the copyright belongs to the authors of the text)
--- Included Text ---
Assessment of tamsulosin as a potential male contraceptive in healthy volunteers.
Wang J1, Zhao Y, Jiang SB, Xia QH, Wei CX, Wang MW, Sun P, Jin XB.
Author information
Abstract
OBJECTIVE:
To investigate the efficacy and safety of tamsulosin, an α(1A)-adrenoceptor antagonist, as a potential male contraceptive.
METHODS:
Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory profile was examined 4 to 6 hours after administration and adverse effects were noted.
RESULTS:
Anejaculation occurred in all subjects after taking 0.8-mg of tamsulosin. Total functional sperm count was significantly reduced in subjects after taking 0.4-mg of tamsulosin. Six subjects receiving 0.8-mg of tamsulosin complained of tolerated discomfort, which disappeared 10 hours after administration.
CONCLUSION:
When administered at 0.8 mg, tamsulosin can cause anejaculation with some transient side effects. Our results imply that tamsulosin and related drugs might potentially be used as male contraceptive agents in the future, which needs more studies to verify.
It's FDA approved for use in the treatment of symptoms of enlarged prostate.
It works by relaxing smooth muscles in the groin. One of its side effects is that during orgasm the muscles that normally contract to divert the flow of semen during ejaculation fail to contract.
The result is anejaculation (the semen flows into the bladder and not out of the penis).
Oddly, when Flomax went generic the money to fund the studies for its use as a male contraceptive dried up.
The United States National Institute of Health ( NIH / CDC ) has an article on the studies that were preformed.
https://www.ncbi.nlm.nih.gov/pubmed/22840866
(I'm including the text as it's listed on a Government website, but be aware the copyright belongs to the authors of the text)
--- Included Text ---
Assessment of tamsulosin as a potential male contraceptive in healthy volunteers.
Wang J1, Zhao Y, Jiang SB, Xia QH, Wei CX, Wang MW, Sun P, Jin XB.
Author information
Abstract
OBJECTIVE:
To investigate the efficacy and safety of tamsulosin, an α(1A)-adrenoceptor antagonist, as a potential male contraceptive.
METHODS:
Forty healthy male volunteers were equally divided into 2 groups, each of which received placebo and tamsulosin sequentially in a crossover manner. Ejaculatory profile was examined 4 to 6 hours after administration and adverse effects were noted.
RESULTS:
Anejaculation occurred in all subjects after taking 0.8-mg of tamsulosin. Total functional sperm count was significantly reduced in subjects after taking 0.4-mg of tamsulosin. Six subjects receiving 0.8-mg of tamsulosin complained of tolerated discomfort, which disappeared 10 hours after administration.
CONCLUSION:
When administered at 0.8 mg, tamsulosin can cause anejaculation with some transient side effects. Our results imply that tamsulosin and related drugs might potentially be used as male contraceptive agents in the future, which needs more studies to verify.
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cutnbulls2ox (imported)
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Re: Researchers studying effectiveness of male birth-control gel
Its great someone is working on new male birth control methods. We sure need more chhoices ! To think we are still using condoms, hundreds of years after their invention is not much progress on such an important and life changing issue for all men.
The hormone based sperm supression methods have been tried since I was a teen. But our balls are such potent sperm factories that getting a man s sperm output low enough to not impregnate requires pretty much turning his balls completely off. It seems like our testosterone production and libido get turned off before our sperm production reaches low enough levels to be reliably sterilized.
The lack of sex drive ruins most hormonal sperm suppression attempts. The man s balls stop working, which causes shrunken balls that most men don t like as a necessary side affect of turning off his sperm production, and a risk he can t get his balls to work again when he wants to have kids. His turned off testosterone production is replaced with artificial testosterone mixed into the sterilization medicine doses to give him a sex drive and allow him to remain masculine in his body and able to get erections to enjoy his sterility in unprotected sex. But usually if a man takes artificial testosterone long enough and in large enough doses to completely replace his normal levels, his balls will turn off and shrink, that risks permanently turning off both his sperm and testosterone production. They can t be re started after too much time of being turned off. Men finished having kids won t mind this. But teens and young men wanting kids some day would need to sperm bank their sperm to ever have any kids. That s expensive and freezing kills some men s sperm. Only some men can freeze and thaw out their sperm to impregnate with frozen sperm. Some men s sperm simply die if you freeze them.
You pretty much have to castrate a man to force his balls to quit making sperm. He loses all of his ball functions before his sperm production finally stops.
Infertile men somehow can keep the full masculinization and erections and sex drive of fully functioning gonads, but are sterile. These men should be studied to see how their testicles can do that. Their form of sterility would be far closer to what most men would want. Especially if that sterility could be turn on in teens and men wanting kids in the future. And turned off when they want to impregnate.
The methods that try to block the sperm from leaving our balls seem more likely to work in ways men would like.
These " clean sheets " methods that aim to prevent ejaculation do sound promising. I m thinking most men will be unhappy having stunted or no ejaculation with those intensely pleasurable contractings and pulses of semen being shot out in ejaculation orgasms. I d hate to lose these intense pleasures and sensations with these methods. If the pleasures of orgasm can be enjoyed, then men will go for it. I m guessing the semen load would still dribble out the open urethral tube in our penises without muscle contractions squirting it out with force ? Unless the valves to our bladder will prevent those released sperm loads from getting out the end of our penises except by pissing it out.
But the work on preventing ejaculation sounds promising and these things dont tamper and mess with our hormones, ball functions, or sperm production at all. That makes it sound far more reversable. Maybe in a short term dose that keeps us from ejaculating for hours and then our bodies return to normal after the dose wears off sounds great. Take it right before sex to knock out our ejaculation muscles for 12 hours of love making. And empty out your full blue balls by jacking off the next day safely away from any woman s body. That would be great !
A drug to let me fuck for hours with no ejaculation, but feeling multiple orgasms would make tons of money.
The hormone based sperm supression methods have been tried since I was a teen. But our balls are such potent sperm factories that getting a man s sperm output low enough to not impregnate requires pretty much turning his balls completely off. It seems like our testosterone production and libido get turned off before our sperm production reaches low enough levels to be reliably sterilized.
The lack of sex drive ruins most hormonal sperm suppression attempts. The man s balls stop working, which causes shrunken balls that most men don t like as a necessary side affect of turning off his sperm production, and a risk he can t get his balls to work again when he wants to have kids. His turned off testosterone production is replaced with artificial testosterone mixed into the sterilization medicine doses to give him a sex drive and allow him to remain masculine in his body and able to get erections to enjoy his sterility in unprotected sex. But usually if a man takes artificial testosterone long enough and in large enough doses to completely replace his normal levels, his balls will turn off and shrink, that risks permanently turning off both his sperm and testosterone production. They can t be re started after too much time of being turned off. Men finished having kids won t mind this. But teens and young men wanting kids some day would need to sperm bank their sperm to ever have any kids. That s expensive and freezing kills some men s sperm. Only some men can freeze and thaw out their sperm to impregnate with frozen sperm. Some men s sperm simply die if you freeze them.
You pretty much have to castrate a man to force his balls to quit making sperm. He loses all of his ball functions before his sperm production finally stops.
Infertile men somehow can keep the full masculinization and erections and sex drive of fully functioning gonads, but are sterile. These men should be studied to see how their testicles can do that. Their form of sterility would be far closer to what most men would want. Especially if that sterility could be turn on in teens and men wanting kids in the future. And turned off when they want to impregnate.
The methods that try to block the sperm from leaving our balls seem more likely to work in ways men would like.
These " clean sheets " methods that aim to prevent ejaculation do sound promising. I m thinking most men will be unhappy having stunted or no ejaculation with those intensely pleasurable contractings and pulses of semen being shot out in ejaculation orgasms. I d hate to lose these intense pleasures and sensations with these methods. If the pleasures of orgasm can be enjoyed, then men will go for it. I m guessing the semen load would still dribble out the open urethral tube in our penises without muscle contractions squirting it out with force ? Unless the valves to our bladder will prevent those released sperm loads from getting out the end of our penises except by pissing it out.
But the work on preventing ejaculation sounds promising and these things dont tamper and mess with our hormones, ball functions, or sperm production at all. That makes it sound far more reversable. Maybe in a short term dose that keeps us from ejaculating for hours and then our bodies return to normal after the dose wears off sounds great. Take it right before sex to knock out our ejaculation muscles for 12 hours of love making. And empty out your full blue balls by jacking off the next day safely away from any woman s body. That would be great !
A drug to let me fuck for hours with no ejaculation, but feeling multiple orgasms would make tons of money.
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ambiguous (imported)
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Re: Researchers studying effectiveness of male birth-control gel
Every now and then such a product goes to trial but gets binned off because of the side effects.
In the age of wearing a rubber to prevent STD's I don't think there will be much interest in this either.
In the age of wearing a rubber to prevent STD's I don't think there will be much interest in this either.
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moi621 (imported)
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Re: Researchers studying effectiveness of male birth-control gel
ambiguous (imported) wrote: Sat Dec 01, 2018 11:22 am Every now and then such a product goes to trial but gets binned off because of the side effects.
In the age of wearing a rubber to prevent STD's I don't think there will be much interest in this either.
The major side effect being impotence with previous attempts.
Moi
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cutnbulls2ox (imported)
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Re: Researchers studying effectiveness of male birth-control gel
I think teens and married men would appreciate a male birth control pill the most. They are the ones going into sex with less condom use than the young single adult men who are forced to rubber up for fun because of the high STD risks among young single adults.
Many teens don t have enough sex or so many sex partners to think of STDs as being as big a risk to themselves in a few sex adventures. To teens, pregnancy is more likely to occur in just a few ejaculations than STDs. Most STDs are curable. So not as much of a mess to cure as an unintended pregnancy. A baby, for a teen, fouls up their lives much more than most STDs would, if the STDs are curable. Most teen males don t want to impregnate as teens. But most teens want the option of impregnating in the future. Guys can t even legally get vasectomies until at least age 18.
Young married men would enjoy the absolute control over if and when they father any babies. They d enjoy choice over their own sperm s use being a male right to control for themselves. But still remain able to impregnate when they want to be able to father babies.
Married men with kids already have all the responsibilities of fatherhood. One more baby isn t a life changing thing to them.
Men who have kids can use vasectomies to end their baby making abilities.
Most older men could enjoy a male birth control pill. But most just go get a vasectomy if impregnating is a big worry to them.
The younger males want and need a male birth control pill or other new and temporary male contraception methods the most.
Many teens don t have enough sex or so many sex partners to think of STDs as being as big a risk to themselves in a few sex adventures. To teens, pregnancy is more likely to occur in just a few ejaculations than STDs. Most STDs are curable. So not as much of a mess to cure as an unintended pregnancy. A baby, for a teen, fouls up their lives much more than most STDs would, if the STDs are curable. Most teen males don t want to impregnate as teens. But most teens want the option of impregnating in the future. Guys can t even legally get vasectomies until at least age 18.
Young married men would enjoy the absolute control over if and when they father any babies. They d enjoy choice over their own sperm s use being a male right to control for themselves. But still remain able to impregnate when they want to be able to father babies.
Married men with kids already have all the responsibilities of fatherhood. One more baby isn t a life changing thing to them.
Men who have kids can use vasectomies to end their baby making abilities.
Most older men could enjoy a male birth control pill. But most just go get a vasectomy if impregnating is a big worry to them.
The younger males want and need a male birth control pill or other new and temporary male contraception methods the most.
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daifu-orchid (imported)
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cutnbulls2ox (imported)
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Re: Researchers studying effectiveness of male birth-control gel
Haha and you re his living proof of male birth control failure !
I ve always wondered how men in extra hot places with air temperatures higher than our body temps, hot for weeks at a time, are not sterile just from the heat ?
No matter how far down their balls reel out to hang low in the heat, the air temp is still too high for making healthy sperm.
If our balls can t be in our abdomen because 98.6 degrees of our body temp is too high for sperm, then how can men make any sperm in places hotter than our body temps ?
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experiment (imported)
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Re: Researchers studying effectiveness of male birth-control gel
cutnbulls2ox (imported) wrote: Thu Dec 20, 2018 11:25 am Haha and you re his living proof of male birth control failure !
I ve always wondered how men in extra hot places with air temperatures higher than our body temps, hot for weeks at a time, are not sterile just from the heat ?
No matter how far down their balls reel out to hang low in the heat, the air temp is still too high for making healthy sperm.
If our balls can t be in our abdomen because 98.6 degrees of our body temp is too high for sperm, then how can men make any sperm in places hotter than our body temps ?
I surmise the temperature does go below 98.8 degrees for sufficient time during the night and in different seasons throughout the world so as to allow the testicles to produce active sperm.
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cutnbulls2ox (imported)
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Re: Researchers studying effectiveness of male birth-control gel
You d think that explains it. But if a man is in 120 or 130 or even 105 degree heat all day long, his sperm would be cooked. It d be cooked sperm inside his balls by the time it cooled down at night.
But then again, men s sperm can live for weeks in his prostate and other sexual glands inside his groin after castration or a vasectomy.
Maybe its the hatching and formation of sperm that are so heat sensative. But high heat during any part of the day, especially with your balls pushed up high and trapped inside tight sweaty crotch clothing, would over heat his sperm.
If our testicles have to be external to keep them cooler than our internal body temperature, how can hours of intense heat not wreck sperm ? .
But then again, men s sperm can live for weeks in his prostate and other sexual glands inside his groin after castration or a vasectomy.
Maybe its the hatching and formation of sperm that are so heat sensative. But high heat during any part of the day, especially with your balls pushed up high and trapped inside tight sweaty crotch clothing, would over heat his sperm.
If our testicles have to be external to keep them cooler than our internal body temperature, how can hours of intense heat not wreck sperm ? .