Has anyone used this combination of drugs to avoid osteoporosis and other problems? My goal is avoid further masculinization after some feminization. I am currently on a dose of 2 mg estrofem and 25 mg cyproterone a day. I plan change the regime to 12.5 mg of androcur and 4 mg of estrofem, then to androcur and raloxifene.

I had used Androcur and Tamoxifen (which is quite similar to Raloxifene). It works very well.

I've been on both (100mg Androcur / 60mg Raloxifene) for 6 months now. That combination doesn't really have a huge impact on preventing osteoporosis, so it's probably advisable to also take calcium and vitamin d supplements.