How Long to Rid the System of Testoterone?

[madnomadtoo (imported)]

How long is needed to deplete serum testosterone after castration?

From "Effectiveness of castration...in producing rapid endocrine control of metastatic cancer of the prostate" https://www.ncbi.nlm.nih.gov/pubmed/3981712

Bilateral orchiectomy produced castrate serum testosterone levels (less than or equal to 50 ng. per 100 ml.) within 2 to 6 hours (mean 3 hours) after surgery.

From "The time for serum testosterone to reach castrate level after bilateral orchiectomy..." https://www.ncbi.nlm.nih.gov/pubmed/8197647

Castration time of bilateral orchiectomy ranges from three to twelve hours (mean, 8.6 hours). The biological half-life of serum testosterone was from thirty to sixty minutes (mean, 45 minutes).

Small sample sizes, 9 and 20 men, as well as testing procedures likely explain the range of response times.

We should all note the mean half-life of natural serum T is only 45 minutes. Contrary to some well-meaning posts here and there, it does not take several days or even weeks to clear T from the bloodstream of a new eunuch. After castration, one becomes a full-blooded, or rather, empty-blooded eunuch in 12 hours at most.

Does this drastic drop account for the common complaint of depression? Such a sudden change in this mood elevating steroid must be keenly felt.

And to what extent does the placebo effect alleviate the onset of depression and castration's other effects if one mistakenly believes the drop in T is more gradual?

[cutnbulls2ox (imported)]

Amazingly fast loss of testosterone ! Frightening how fast testosterone disappears from men s blood after castration.

I m just guessing here, but maybe the affects of testosterone on male sex organs such as the penis, prostate, hair growth, mood, and sex drive can remain influencing that organ for some time after the last dose of testosterone. Maybe that is why erections and prostates take a longer time to atrophy and disappearor become impotent over a longer time.

Just like puberty and increases in testosterone take a long time to masculinize boys into men, testosterone s visible and functional effects are not immediate coming into or leaving male body parts.

[daifu-orchid (imported)]

Strange that T is so short-lived, but its effects are so slow.

I don't doubt that I had practically zero T within a day of being nutted, but it took many weeks to get to hot flashes and no penis activity.

.

[justine77 (imported)]

Hi, change in muscle tone within a few days of being cut, inability to get an erection after about 2 weeks, then gradual loss of body hair until becoming close to 100 pc smooth after 6 months as a eunuch.

Justine x

[madnomadtoo (imported)]

Amazingly fast loss of testosterone ! Frightening how fast testosterone disappears from men s blood after castration.

I m just guessing here, but maybe the affects of testosterone on male sex organs such as the penis, prostate, hair growth, mood, and sex drive can remain influencing that organ for some time after the last dose of testosterone. Maybe that is why erections and prostates take a longer time to atrophy and disappearor become impotent over a longer time.

Just like puberty and increases in testosterone take a long time to masculinize boys into men, testosterone s visible and functional effects are not immediate coming into or leaving male body parts.

True, the effects of castration may not match the precipitous drop of T itself, but those effects are predictable, dependable and inexorable.

Consider osteoporosis. We don't expect our bones to snap 12 hours after the snip, but we know that gradual deterioration begins immediately.

I didn't grow my hips and tits overnight, but after 20 years of hypogonadism here they are. Those who undergo castration to control runaway sex urges always seem ultimately satisfied with the results.

In fact, this may be why some think that T dwindles away slowly, because they draw a false correlation with the gradual onset of "symptoms."

The effects of T deprivation lie along a spectrum unique to every man. Some claim to maintain a satisfying sex life, enjoy that "eunuch calm," and feel enervated. Then there are the others, like me, for whom hot flashes, fatigue, confusion and depression lie only a handful of days beyond that missed T shot.

To state it in scientific terms, your mileage may vary.

[madnomadtoo (imported)]

Hi, change in muscle tone within a few days of being cut, inability to get an erection after about 2 weeks, then gradual loss of body hair until becoming close to 100 pc smooth after 6 months as a eunuch.

Justine x

Interesting. Thanks for sharing. What was your body hair like originally? I was very hirsute. Took a lot longer than 6 months, but now if someone insults me with "you don't have a hair on your ass," I have to say, well, no, I DON'T have a hair on my ass!

[justine77 (imported)]

Hi, before I was nutted my body hair was quite fine and silky. My natural color is blonde. I had hair on my arms and legs and a thick pubic bush. I had barely any other body hair and no facial hair. After my castration I started to lose body hair within a month or two. After 6 months I'd lost 95 pc of my body hair and 100 pc of pubic hair. The pubic hair loss shocked me a bit since that was where I had the most. Even after a year on TRT there's no sign of it growing back, I'm still completely smooth down there. I opened a thread on the Surgical Castration forum to ask about it (early April this year I think). Some of the guys here said it's a good thing, no depilation required etc. I'm used to being smooth now, it gives me a more feminine (or possibly eunuch) appearance. Justine x

[erikboy (imported)]

Blood serum levels of T may drop very fast, but it takes much more time for testosterone to leave T receptors. Other systems in chain get affected more slowly, like bone density and muscle mass.

[daifu-orchid (imported)]

A fairly recent JAMA meta-study (I recall some 30 papers) seems to suggest that while osteoporosis is common with increasing birthdays (and therefore loss of T, among other factors), replacement of Vit D and Calcium did benefit osteoporosis but not the risk of fracture. It seems that there is no excuse not to get off our lazy asses and do weight-bearing exercise. That fixes it, but we'd rather take a tablet.... (A whole other question...)

No substitute for professional guidance from a good doc to keep us well!

[madnomadtoo (imported)]

Blood serum levels of T may drop very fast, but it takes much more time for testosterone to leave T receptors. Other systems in chain get affected more slowly, like bone density and muscle mass.

Don't stop there. Tell us more. I take it this is why the effects of T deprivation take a while to show up? Dump more knowledge on us, please.