Hi all.

About 4 months back I did a androcur trial and enjoyed he experience

Was looking into doing another few months and was concidering bicalutamide.

Has anyone here tried this. Reading up on it it's seems different to androcur . The way that it works.

Feedback here is always great.

Bicalutamide is interesting in that it might not cause permanent sterility. From the wikipedia article:

"In contrast to bicalutamide and other pure antiandrogens/NSAAs, antigonadotropic antiandrogens suppress gonadotropin secretion, which in turn diminishes testosterone production by the testes as well as the maintenance of the testes by FSH, resulting in atrophy and loss of their function.[347] As such, bicalutamide and other NSAAs may uniquely have the potential to preserve testicular function and spermatogenesis and thus male fertility relative to alternative therapies.[171][348] In accordance with this notion, a study found that prolonged, high-dose bicalutamide treatment had minimal effects on fertility in male rats.[149] However, another study found that low-dose bicalutamide administration resulted in testicular atrophy and reduced the germ cell count in the testes of male rats by almost 50%, though the rate of successful fertilization and pregnancy following mating was not assessed.[349]"

Also from the wikipedia article:

"Unlike with antigonadotropic antiandrogens such as CPA and GnRH analogues, it has been reported that bicalutamide monotherapy (at 50 mg/day) has very little effect on the ultrastructure of the testes and on sperm maturation in humans even after long-term therapy (>4 years).[171] This may be explained by the extremely high local levels of testosterone in the testes, in that it is likely that systemic bicalutamide therapy is unable to produce intratesticular concentrations of the drug that are able to significantly block androgen action in this part of the body."

I have not tried bicalutamide myself but I do know others who have. I don't know any who have erm... tested their fertility afterwards, but it does look like a promising antiandrogen for those who wish to preserve their fertility.

So if you're looking to do another trial bicalutamide seems like a good option if one would like higher chances of preserving fertility, but you should look into it more for yourself. It's also less harmful to the liver than cyproterone so that is another upside to it.

Thanks for the info. Very useful. Also been thinking about finasteride and it's less expensive

Finasteride IIRC is mainly effective against DHT conversion rather than as a straight up testosterone blocker. Someone else can feel free to correct me. If your concern is cost that's understandable, bicalutamide does tend to be expensive in comparison to other test blockers but there are some cheaper online sources. I know a few people who get it from QHI, one must first ask them for it as they do not have it listed, but they do indeed sell it, and from what I've heard it's at a good rate compared to other places. Worth looking into if you want to try bicalutamide.

Cyproterone acetate is worth looking into too if you don't care about fertility, have a healthy liver, and want a pretty effective anti androgen.

I have ordered 5mg Finasteride to try. Lots of info online regarding causing impotence which is a side affect I want.

Mescottyg86 (imported) wrote: Mon Jan 02, 2017 11:44 am I have ordered 5mg Finasteride to try. Lots of info online regarding causing impotence which is a side affect I want.

i am on "fincar" since 6 month..trust me ...works well !! best reg. GWENY