Abstract

Androgen deprivation therapy (ADT) for prostate cancer (PCa) treatment causes sexual dysfunction. We review here the effects of estrogen on the sexual performance of androgen-deprived males. The major findings are:

1. Estrogen receptors are present in brain centers that are important for sexual behavior; as well as in male reproductive organs, in a pattern suggesting that estrogen may have some role in orgasmic function and genital skin sensitivity.

2. Estrogen restores sexual interest above castrate levels in many vertebrates including reptiles, birds and mammals; but multiple factors contribute to the magnitude of this effect.

3. Data from castrated men, aromatase-deficient men, male-to-female transsexuals, and men on antiandrogens all suggest that estrogen can maintain some libido in androgen-deprived men.

We discuss the general benefits of estrogen therapy to quality of life of men on ADT, the potential risks of this treatment, and possible treatment regimes for estrogen therapy in males. Unless contraindicated, we propose that PCa patients on ADT would benefit from supplemental parenteral estrogen.

Keywords: Androgen deprivation therapy, Prostate cancer, Libido, Estrogen, Male sexual function, Castrated animals, Orgasm, Skin sensitivity.

http://qualityoflife.elsevierresource.c ... s/fulltext

This is a fascinating paper from Richard J. Wassersug a respected professor and fellow eunuch. I know my own estrogen therapy works for me.

A big problem I see with it is that it is all based using synthetic estrogens which have a lot of negative side effects compared to estrodiol. This is the big flaw that caused the flawed results of the WHI and caused millions of WOMEN to needlessly quit taking HRT.

Though I'm no expert. I think all estrogen medication is synthetic except the one that comes from pregnant horses.

I sent a copy of the first three items in this thread to Erik Wibowo to let him know that his work has been cited here. He responded:

I believe the WHI was terminated because of cognitive concerns... JessicaH needs to be aware that the WHI data has been re-analyzed and it has shown that the impact of E on cognition function depends on when the treatment is started after menopause; i.e., if given around the perimenopausal period, E can have cognitive benefits, but it can be cognitively harmful if administered years after menopause.

Erik is a recent PhD in neuroanatomy whose dissertation demonstrated that estrogen could help maintain MALE sexual functioning in rats castrated after male puberty. This is, of course, of great interest to prostate cancer patients, though probably less so to voluntary eunuchs. Erik is interested in the voluntary eunuch community and has been my co-author on a couple of papers. I'm hoping that he will take over as I age out of competence.

Thanks, Jesus. I will have to look back at some of my sources and get back with you. There is a great deal of evidence showing differences in negative side effects of many of the synthetic estrogens that do not apply to human equivilent estrodiol. The same goes when you compare progestins like provera to to bio-eqivilent progesterone USP. I will have to get documentation to back up my assertion or it's just more "blah blah blah" on the internet.

For cognitive concerns, this looks very promising for those that want to avoid feminization.

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

http://stm.sciencemag.org/content/7/297/297ra113