SPIRO INCREASES YOUR BODY'S BLOOD LEVELS of CORTISOL (#1) and

ELEVATED CORTISOL INTERFERES with YOUR BODY'S USE OF GLUCOSE and INTERFERES WITH YOUR MEMORY, as WELL (#2)

Rachel Francon https://www.facebook.com/groups/GenderResearch/

Two for the price of one.

A bargain for all the Spiro Girls out there, don't you think?

If readers haven't already taken too much Spironolactone, they should be able to connect the dots and put #1 and #2 together?

As we have stated in our group time and again, Short-term increases in cortisol are truly critical for survival. They promote coping and help us respond to life’s challenges by making us more alert and able to think on our feet.

BUT ABNORMALLY HIGH or PROLONGED SPIKES in CORTISOL—like what happens when we are dealing with long-term stress—can lead to negative consequences that numerous bodies of research have shown to include digestion problems, anxiety, weight gain and high blood pressure.

One of the things that happens when Spiro or other blockers of the MR (Mineralocordicoid Receptors) in the Brain are taken is that they sabotage the negative feedback system in the brain that diminishes cortisol production after the initial and useful spikes Thus they lead prolonger or abnormally hihg spikes of cortisol.

FIRST STUDY: Spiro ELEVATES your CORTISOL LEVELS and INTERFERES WITH BODY's GLUCOSE CONTROL & DIABETES RISK.

In the first study included in this post, the authors, in their research article (see link immediatlely below) confirm this for the non-believers out there what we have reiterated in Gender Research Group for month after month.

http://www.medscape.com/viewarticle/733889

Taking Spiro tends to increase your levels of cortisol (which is a stress and glucose regulating hormone).

This is not good. It not only affects your brain, which we have documented by its interference with the MR receptors in the brain, but it interferes with MR receptors elsewhere causing weight gain around the middle, increased appetite and ultimately problems with blood glucose.

The authors, in the first article are concerned with whether Spiro increases cortisol levels...AND..they demonstrate, in their own words, that it does harm the overall health of the person, by disrupting their glucose metabolism and elevating blood glucose, according to a prime diabetes risk indicator , Hb1Ac:

Their research deals with comparing Spiro to Epierenone, which is used more frequently than Spironolactone nowadays for Blood Pressure control and lowering.

"MR antagonist binds and blocks not only MR but also other steroid hormone receptors.

Eplerenone is a more selective MR antagonist compared to spironolactone.

Therefore, there may be a difference in the degree of increase in corticosteroid levels between eplerenone and spironolactone and consequently there may be a difference in metabolic effects such as HbA1c levels and insulin resistance."

the present study compared the effects of selective MR antagonist eplerenone and spironolactone on plasma levels of HbA1c and adiponectin, which represent insulin sensitivity, and serum cortisol levels in patients with CHF who were already receiving standard therapy.”

What these researchers demonstrate in this article is that while Spiro INCREASES CORTISOL LEVELS, the other medication did not.

For the health of the body of the person taking Spiro this means:

As a result of the increased Cortisol produced by the Spiro, there was a negative and unhealthy change in HbA1c. If you ask your doctor about this, he or she should know that the HBA1c is a primary indicator of diabetes risk because it revealed a chronic patterns of excessive blood sugar.

The authors state (in their own words):

"In patients receiving spironolactone (n = 34), plasma adiponectin levels were significantly decreasedand HbA1c and cortisol levels were significantly increased n patients receiving spironolactone, there was a significant positive correlation between the change in cortisol and the change in HbA1c

In contrast, in patients receiving eplerenone (n = 73), plasma levels of adiponectin, HbA1c and cortisol did not change.”

SECOND STUDY: WHAT ELEVATED CORTISOL DOES to your BRAIN and HOW IT IMPAIRS MEMORY

In this second study, the UI researchers linked elevated amounts of cortisol to the gradual loss of synapses in the prefrontal cortex, the region of the brain that houses short-term memory. Synapses are the connections that help us process, store and recall information.

And when we get older, repeated and long-term exposure to cortisol can cause them to shrink and disappear.

“Stress hormones are one mechanism that we believe leads to weathering of the brain,” Jason Radley, assistant professor in psychology at the UI and corresponding author on the paper. Like a rock on the shoreline, after years and years it will eventually break down and disappear.

http://medicalxpress.com/news/2014-06-s ... icits.html

Hmmmm....What could this be?

Elevated Stress Hormone (Cortisol) leads to Short Term Memory loss?

And what do we know often causes elevation of cortisol stress hormone? Spiro, of course.

Are you getting a simple saliva test for cortisol? Or feeling disruption of your diurnal cortisol rhythm as evidenced by fatigue, insomnia, weight gain.. around the middle or your face , insulin resistance or thyroid issues.? Or worse.

Or don't you remember? Because your short term memory is fading as we speak? Or you already have too many ADHD symptoms?

Stress hormone linked to short-term memory loss as we age

A new study at the University of Iowa reports a potential link between stress hormones and short-term memory loss in older adults.

medicalxpress.com

So what the hell are we trans people supposed to do? Seriously? First Finasteride/Dutasteride was bad, now Spiro is bad, so what else am I supposed to do? Just let testosterone run amok again? Are you suggesting that androcur is better? Just trying to figure out what you're suggesting we should do.

Androcur IS better but E has been proven effective for T suppression by itself in the correct dosage. Most docs just under prescribe E.

https://endo.confex.com/endo/2014endo/w ... 15498.html

So having enough E solves the problem of T and DHT. It's actually a much simpler plan with no additional chemicals that act as a shotgun blast no the neuro-endocrine system.

Okay Jessica..I read that doctor-jargon..What's the prescribed dosage of E? I'm taking 4 mgs daily of estradiol.....What's the prescribed dosage??smooches..(you look great, by the way) Jackie (who still gets slight penile twitches...I want them gone)

butterflyjack (imported) wrote: Tue Jul 15, 2014 7:18 am Okay Jessica..I read that doctor-jargon..What's the prescribed dosage of E? I'm taking 4 mgs daily of estradiol.....What's the prescribed dosage??smooches..(you look great, by the way) Jackie (who still gets slight penile twitches...I want them gone)

It´s a very interesting thread that is worth to follow.

I´m gonna start 4mg valerate estradiol also! In fact that´s the average prescribed dosage. Some need even 6 to 8. I´m worry about what Has been said of spiro since I am thinking switch to It from androcur. On the other hand I´m very afraid from Depo because of Its side effects. I´m gonna start spiro increasing slowly up to 150mg per day and 4mg Estradiol valerte. As far as I know estradiol pills are less effective to low T by alone. Injectable forms are more efecttive. 10mg per week IM. would be ok and It will work alone for supressing T. Unfortunately in my country EV is not available.

I can´t definitely afford for androcur anymore, It´s known about the safety of spiro, but this article has made me hesitate.

Jackie how are you doing on 4mg EV daily?

Cortisol poisoning is especially pernicious prenatally, as it permanently alters gene expression in the fetus in ways that ensure a stressed and unhappy life.

The more you know, and all.

I guess it's probably doing the same sort of thing to anyone who has to live with a chronic exposure to the stuff, but somewhat more reversibly.

I heard that androcur reduces it but idk if this is good or bad

Both high or low cortisol are bad. Cortisol is the "stress" hormone. When is high, rise blood pressure, glucose etc. When is low pressure falls down and glucose levels too. Is esencial for living.