Hi, I've been trying to reduce my sex drive with GnRH agonists recently. At first I used Buserelin nasal spray for one month but it was too expensive (it's not registered in Estonia and hence the insurance does not cover it). I then switched to Triptorelin 3.75 mg for a month. I'll have my next injection of Triptorelin in a couple of days. I have to say that the results are disappointing so far. On one hand, I've been in a better mood recently and been thinking less about sex. But this is probably just because it's summer. I live alone but stay in my mother's house often - when I'm there, I don't masturbate at all (as I'm rarely home alone). When I'm in my place, I still need the urge to masturbate at least once a day. I called my doctor today and asked for a prescription of Triptorelin. I also asked if it would be OK to inject it more frequently, in essence raising the dosage. He said it might be OK. So I think I'll try it.

Has anyone else used GnRH agonists? They are said to be very effective drugs.

All chem castration work well, the difference are; anti androgen will destroy or block testosterone, while GnRH agonists will stop T production completely. When a man start to use chemical castration, his system try to counter weight the effects of medication. This results in a higher testosterone production for 2-3 weeks up until the medication over rides the T production. At the beginning you must take more medicine and later reduce it, after 1-2 years you might not need to take any.

paring (imported) wrote: Thu Jul 04, 2013 8:53 am All chem castration work well, the difference are; anti androgen will destroy or block testosterone, while GnRH agonists will stop T production completely. When a man start to use chemical castration, his system try to counter weight the effects of medication. This results in a higher testosterone production for 2-3 weeks up until the medication over rides the T production. At the beginning you must take more medicine and later reduce it, after 1-2 years you might not need to take any.

Would a (too) low dose actually result in a higher level of testosterone?

They are the most effective but they're also the newest and most expensive (considerably more than any other CC drug). Because of the "testosterone flare" that they cause when first administered (particularly dangerous to prostate cancer patients), the usual practice is for the patient to take Androcur for a few weeks and then go onto the lupron or whatever. But the cost means that very few men who want to be castrated have access to it.

A low dose of anti androgen won't have much effects, the endocrine system will always try to produce testosterone to bring it to a normal level up until it can't produce enough T, only then the anti androgen will have an effects. I presume that men with larger testicles have the capacity to produce more T than men with smaller ones, so they will probably require more anti androgen to lower theirs T levels.