impotentus (imported) wrote: Wed May 09, 2012 5:52 am a bit of information on this. Where I live, depo-provera is NOT an over the counter drug. You actually need a medical prescription for it. but, spiro, finasteride and estrogen(even if it souns odd) are easily obtainable. Also, the doctor just went to attend some conference in another city. he should be here soon, but I don`t like my libido getting back.

SplitDik (imported) wrote: Tue May 08, 2012 8:18 pm I personally think that depo-provera is a hit-or-miss type thing with respect to chemical castration. It basically works indirectly -- technically it is a precursor to both estrogen and testosterone, and it is only through a secondary effect where too much will suppress testosterone. You'd do better to do something that is directly binding to androgen receptors or otherwise directly blocking the effect or the production of testoterone.

Furthermore, the injections of depo-provera cause a lot of variation in actual circulating levels. The half-life of depo in a male is actually quite short (about 50 hours if I remember), meaning that if it all entered the blood stream at once that it would only have half the level within two days! So men need injections really frequently, maybe even weekly, if you really wanted stable levels. The injections are intra-muscular so will seep into the blood at different rates depending on the exact spot of injection. For someone who naturally already isn't producing much testosterone (maybe already somewhat castrate), the half life is much much longer. So if you're taking other anti-androgens at the same time you really have no control over the depo level and effect.

A daily pill of something that blocks testosterone directly is a much more predictable bet.