Anyone have any experience with or know anyone who has been on Lupron? My endocrinologist says he may start me on Lupron to squelch my hypersexuality.

See if Guy26 is still hanging around. He did some experimenting with Lupron a while back. He posted extensively about it, and much of his soul searching at the time. Might be worth looking up.

I am about to have a Lupron shot today as part of treatment for prostrate cancer. My doctor told me it eliminates 90% of the testestrone and in my case is being used in conjunction with casodex which i take daily. If you think it would be helpful i would try to answer more specific questions.

Yes! Please do keep me informed! Thanks!!!

If you have a specific question about Lupron, I would be happy to answer it. Out of curiosity, how much Lupron are you receiving? The larger the amount, the longer it will stay in your system.

I haven't started on Lupron yet but probably will soon after I have Gastric Bypass surgery which will probably happen over Spring Break in March. I guess my two questions about Lupron would be does it really raise your hormone level for the first month before it starts lowering your hormone level and are you happy with your results?

Thanks!

Lupron does raise your hormone levels for a short while, but it is short lived. I would expect about 3-4 days of elevated testosterone (peaking at 150% of your normal) levels followed by a quick crash in testosterone levels over the next couple of weeks. By week three you will almost certainly be sitting at castrate levels. It is a very powerful anti-androgen. It's way more powerful compared to Depo Provera.

Yes, I was happy with the results. The bottom line is it prevented me from acting out on my drive toward castration. A month on it was enough to re-set the overwhelming drive to follow through on castration. The pressure is of course slowly building again. I have normally taken depo provera in the past to take a vacation from testosterone when it was reaching critical levels.

I am seeing an endocrinologist for the first time today, so I'm hopeful he will listen to my unusual problem and be sympathetic. I think the easiest way to describe my problem is that I am genderqueer and have an atypical kind of gender disphorphia. I don't feel like a guy, but I sure as hell don't feel like a woman either. If you don't accept gender as being a spectrum between male and female as opposed to only being male or female, my problem is hard to understand. My gender incongruity eats at me with a persistence that is hard to ignore over the long run. It's complicated by the fact that I have bipolar type II. When I experience hypersexuality during hypomania, this problem quickly reaches a tipping point where I feel overwhelmingly driven to act on it and castrate myself.

I have had great pause ever since I took Lupron. I did not react to the testosterone surge in an expected way. I thought that I might feel short tempered and aggressive, that it might mess with my mood, that it might make me feel excessively sexually driven, that it might make the gender incongruity even worse. None of that happened. I really don't know why, but for the first time in my life I felt like a guy. It still bothers me to this day that I cannot explain why. I don't know what specifically made me feel like a guy, but every fiber of my being felt like a guy for the first time in life. I can only tell you that it was one of the most profound things that I have experienced in life.

I don't know how physiologically reasonable it is to experience that high of a testosterone level some of the time or all of the time (I'm guessing I was at 125% of normal), but my therapist has asked me to consider it and talk to my endocrinologist about this option. Initially, I found it an endless source of philosophical questions. I've gotten past that and feel okay giving it a try assuming the endocrinologist feels its okay. Being normal wouldn't necessarily make me more happy, but it would sure be easier!