Hello,

Is it possible an high dosage of androcur (cyproterone) to have an opposite effect (raised testo)?

Some people here might remember me. I was almost at castration levels with only 25mg/day and when I advised from my doc to raise the dosage, my testo raised too. He says to be patient but it's almost eight months and have not reach even near castration levels. In particular my testo has raised progressively like my dosage did. Is there anyway that I can diagnosed for a bad body feedback reaction? How is it possible to have the opposite results?

Hello,

mantonis (imported) wrote: Tue Apr 13, 2010 12:21 am Is it possible an high dosage of androcur (cyproterone) to have an opposite effect (raised testo)?

Some people here might remember me. I was almost at castration levels with only 25mg/day and when I advised from my doc to raise the dosage, my testo raised too. He says to be patient but it's almost eight months and have not reach even near castration levels. In particular my testo has raised progressively like my dosage did. Is there anyway that I can diagnosed for a bad body feedback reaction? How is it possible to have the opposite results?

your not on a castration dose at 25 mg. There will be an initial rebound effect but it shouldnt last long. Suggest a new doctor perhaps.

kristoff wrote: Tue Apr 13, 2010 4:21 am your not on a castration dose at 25 mg. There will be an initial rebound effect but it shouldnt last long. Suggest a new doctor perhaps.

When I was at 25mg I was self administrated, so I was afraid to take more. Why do you suggest me to find a new doctor since you believe it's a temporary rebound effect.

mantonis (imported) wrote: Tue Apr 13, 2010 5:17 am When I was at 25mg I was self administrated, so I was afraid to take more. Why do you suggest me to find a new doctor since you believe it's a temporary rebound effect.

My presumption is your doctor was prescribing. Most people who use CA start at 100-150 mg per day then titrate down to a maintenance dose over a few months. If a doc was starting you off so low, he was humoring you.

When starting at an effective level of CA or DP or such, it is common to see a temporary spike in testosterone production as the body fights to over come the shut down of production. But it will wane if there is an effective shut down.

kristoff wrote: Tue Apr 13, 2010 3:36 pm My presumption is your doctor was prescribing. Most people who use CA start at 100-150 mg per day then titrate down to a maintenance dose over a few months. If a doc was starting you off so low, he was humoring you.

When starting at an effective level of CA or DP or such, it is common to see a temporary spike in testosterone production as the body fights to over come the shut down of production. But it will wane if there is an effective shut down.

No he did not advised me to start so low. I did. I was taking 25mgr without having a doc cause I was afraid to take more since I was self administrated. But I did had a blood test with only 0.85ng/ml.

First question. Why are you worrying about T level? If other indicators - lack of sex desire, reduced beard growth and body hair, lack of spontaneous erections (nocturnal, morning) - are where you want them, why do you care about T level?

I was on Cyproterone Acetate (generic Androcur) for five years and have been on for first five of last ten months. I start with two 50mg tablets per day and backed off to 1/2 tablet (25mg) twice per day. Although my testosterone dropped to 77ng/dL (note 100 mL in a dL), therefore 0.77 ng/mL, I felt castrated.

Although my T did not go to castrate level, 20-50 ng/dL, I attribute that to the Cyproterone blocking testosterone attachment to androgen dependent cells. Therefore, the only "way out", so to speak, for the testosterone is via clearance from the kidneys. The less testosterone is removed from the blood, the higher the equilibrium level. But with Cypro, what little testosterone is left in the blood is still blocked from being used by the Cypro, so the testosterone getting to your cells is much less than castrate level.

I think this is what, in Anrogen Deprivation Treatment, is called double blockade. You have no testicular testosterone plus whatever is left from other sources (adrenal) is blocked from acting.

If you really want to know, have your doctor do a test for Leutenizing hormone (LH). If it's zero, your testicles are no longer being stimulated to make testosterone. They've become non-functioning ornaments.

With 100mgr/day I went to 2.85ng/ml !

Again, I think the doctor should check for leutinizing hormone. Then you'll know if testicular production of testosterone should have stopped. If testicular production has halted, your T level should be an equilibrium between conversion from adrenal androgens and removal by kidney clearance and

Lee (imported) wrote: Wed Apr 14, 2010 8:13 am attachment to androgen dependent cells.

In the case of a woman, who has little or no androgen dependent cells, removal is almost totally via the kidneys, and women normally have no more than 75 ng/dL (.75 ng/mL). You are either making too much testosterone from adrenal androgens or not removing it quickly by the kidneys. I read recently that one source of high testosterone is too much adrenal androgens due to a tumor. There could also be a kidney problem slowing removal. So, you might have stumbled on another physical problem.

I can think of one way of testing kidney function, by injecting you with testosterone and taking periodic blood tests (every couple of hours). The T level should come down exponentially, with a half life of about 2-4 hours. Slower removal might indicate a kidney problem.

Are you sure you are using a "fresh" sample of CA?