I am a Trans-Gendered M2F and I have been taking Spiro for over 7 months as well as Premarin and I've noticed that my testicle seem to be shrinking this is a good thing as far as I'm concerned, However with that said would shrinkage be considered normal. I am currently taking 225MG daily of Spiro and 2.5MG premarin.

I have a strong desire if not need to be castrated I'll need to keep the scrotum in order to form the Neo Vagina when I am able to get the SRS, so the question is am I being chemically Castrated with the Spiro if so why am I still as horny as I've ever been. I'll assume that the premarin has something to do with that, but I'm not sure.

When I masterbate the ejaculate is mostly clear with very little cloudiness I'll also assume that this means that the Semen production has ceased or has nearly ceased.

Any responces would be helpful

Thanks.

I don't want to sound insulting but you do know that women have sex drive right? And when your on a hormone mix that is female you should expect to have a sex drive at least equal to what your trying to achieve. HRT might mess up erections but sexual needs and ability to climax won't change.

Are you in therapy? Have you talked to your GP about your Hormone mix? What are your latest labs? Maybe yourT to E mix is off?

Good luck

seriouslycurios (imported) wrote: Wed Nov 12, 2008 12:40 pm I am a Trans-Gendered M2F and I have been taking Spiro for over 7 months as well as Premarin and I've noticed that my testicle seem to be shrinking this is a good thing as far as I'm concerned, However with that said would shrinkage be considered normal. I am currently taking 225MG daily of Spiro and 2.5MG premarin.

I have a strong desire if not need to be castrated I'll need to keep the scrotum in order to form the Neo Vagina when I am able to get the SRS, so the question is am I being chemically Castrated with the Spiro if so why am I still as horny as I've ever been. I'll assume that the premarin has something to do with that, but I'm not sure.

When I masterbate the ejaculate is mostly clear with very little cloudiness I'll also assume that this means that the Semen production has ceased or has nearly ceased.

Any responces would be helpful

Thanks.

I've been on 100mg/spiro for 5 years now, and your results (on your higher dose) are about what i experienced after a year plus. Contrary to popular belief, women do have testosterone, produced in the adrenal gland, and their testosterone is responsible for their sex drives. Even after 5 years of estradiol and spirinolactone, I have a weak and mostly mental sex drive. Ejaculation is rare, usually just a few drops of prostate fluid, and only when I get off really hard. I'm not sure why sex drive lingers on antiandrogens. Might be the particular way spiro works, might be force of habit, might be residual testosterone? I would ask my doc, but I'm already gaming them (as it is hard to tell entrenched gender therapists that one wishes to transition to androgyne - but that is its own story) so I tend to just tell them what they need to hear...

Anyhow, what I'm trying to say is that your sex drive will taper down slowly at this point if you're anything like me. I saw minimal shrinkage until about 2 years ago, but these days they are teeny-grape sized.... Have patience. Puberty takes a while even the first time. Those of us who do it again as adults need to recognize that it will be even slower the second time around. Also, sometimes it's hard to perceive all the changes, as we experience it seamlessly, day to day. See where you are at the year mark, the year and a half mark. Your estrogen dose seems perfectly reasonable, and your spiro is over twice what I was prescribed, so I think your endocrine adjustments are appropriate. Much luck, and keep us posted.

Do you still have morning erections? I've always heard that's a sign

your T level is too high. Shrinkage is normal, I was very small

at 3 months and I was around 100mg spiro.

Why did you choose Premarin, these days there are so many better

methods to get Estrogen.

Mandy

I am not sure about your comments on clearness and volume of ejaculate. The principal component of semen is produced by the prostate which is combined with the production from the testicles and stored in the smeinal vesicles. I don't know how the prostate coontribution would be affected by changes to the testicles? Any one have any insights into this?

Maybe the prostate is in fact controlled and managed by the testosterone floating around in the system and likewise reduces in size and production along with the testes??

Francis (imported) wrote: Wed Nov 12, 2008 8:13 pm I am not sure about your comments on clearness and volume of ejaculate. The principal component of semen is produced by the prostate which is combined with the production from the testicles and stored in the smeinal vesicles. I don't know how the prostate coontribution would be affected by changes to the testicles? Any one have any insights into this?

Maybe the prostate is in fact controlled and managed by the testosterone floating around in the system and likewise reduces in size and production along with the testes??

The amount of ejaculate is greatly reduced when testosterone is reduced. The prostrate gland is also becomes smaller.

When a guy starts having problems to pee in his later years the doctor may give him Proscar or Flowmax. Both drugs work on one part of the male hormone. It helps shrink the prostrate. Side effect is reduced ejaculate as noted on the lable. _______

Im neuter androgyne living as a woman, Im on 200mg of spyro and like you the first time I took it for around 5 months and there was no change in my sex life other than I didnt feel like I had to do anything about an erection most of the time unless I wanted to. This time Im on 200mg of spiro and 4mg estrofem (I wouldnt live any other way) and no sex drive but Im sure that androgens only effected my physical labido I think my emotions alowed me to keep my typical sex drive before and now they keep it away. I can still function If I want to but I just dont have any emotional need. I dont think more than 200mg of spyrone is needed but I wasnt satisfied with less than 4mg estradiol and I had unwanted erections when I was at 2mg. maybe uping your estradiol would lower your sex drive if thats what you want. also if your on any progestins that might increase labido as well. The shrinking is typical. This is my first time replying on here so I hope it helped.

~Clair

Wow! Lots of info to sift through.

One of the main reasons that I'm on Premarin is thats what my Doctor at the ** started me on. For many of you, loosing your sex drive is important and that is well understood by me however I for one want to continue having sex As a Woman once the SRS is completed and so even though it takes more consentration on my part to masterbate the end result is just as pleasurable as before I started the transition.

I am also well aware of the fact the the Female body produces T naturally but that it is considerably less than that of a male, conversley the male body produces Estogen as well. One of the things that I was inquiring about is the testicle shrikage and from what I've gathered from the responces thus far is that shrikage is normal and I thank you for that, but what I havent been able to ascertain is the cloudiness of the seminal fluid since mine is mostly clear I again have to assume that the clearness is a result of the lack of testosterone being produced by the testicles thus reducing the sperm (cloudiness) if you will.

I have been seeing a therapist for 11 months now and she doesn't quite know what to make of me I accepted the fact that I am Trans-gendered completely and because of that acceptance I was able to leave the baggage associated with it behind me and because of that I only see my therapist on a monthly rotation. Also I have been living full time as a Woman now for about 10 months.

I do have one other question and that is how long must one be on Spiro for the effects to be permanent, becoming completely chemically castrated I understand that each individual is different and therfor the time frame will be different for each but there must be some sort of bench mark that I can measure against

thank you all for your reponces.

I'm new to posting but have been a lurker for over a year. I have tried a few different Anti-androgens over the last six months to try to reduce my out of control sex drive, the strongest was Siterone (generic Androcur) in the month i was on it my libido dropped to almost nothing and ejaculate turned clear, watery and reduced in quanity but it also has the most side effects and for me that was real low bp problems, currently i'm taking Calutide (generic Casodex) 25mg every other day and Spirotone (generic Spironolactone) 100mg x 2 a day built up to that amount over a couple months, my results have stayed the same on what i'm currently taking, as my Spirotone starts to run out i will wean myself off it till i'm just on Calutide. My scrotum is about 50% the size it was a few months ago. Because of medical problems i have severe ED but can get off using a vibrator when I want, the mind has lots to do with libido and being horny. you might want to look into joining the tsdoityourselfhormones.com site, even if you are under a doctors care there are real good resources there in addition to EA. I am taking Estrogel to help reduce chances for ostioporsys (sp) and to feminise myself some, i would suggest strongly about changing from Premarine to a 17 b type estradiol it has less chance for DVT.