Medical Studies on the effects of castration
Posted: Wed Nov 05, 2008 6:56 am
Here is a thread to post medical studies on the effects of loss of testosterone. NOTE: Castrated can mean surgical (bi-later orchidectomy; both testes removed resulting in a eunuch) or chemical loss of testosterone resulting in a castrate (but not a eunuch). Frequently we think of a "castrated" man as being a eunuch, which can be true, but might not be true. Being a non-eunuch castrate may mean little or no testosterone but the testes produce and interact with the pituitary and other hormones. Thus studies done on non-eunuch castrates and on eunuch castrates will yield different results.
Study #1: Confirmation of what we know. Eunuchs not receiving supplemental testosterone will experience actual bone loss, the effects of which are not discussed here.
http://lib.bioinfo.pl/meid:224717
Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling.
[My paper] J J Stĕpán, M Lachman, J Zvĕrina, V Pacovský, D J Baylink
Department of Medicine 3, Charles University Faculty of Medicine, Prague, Czechoslovakia.
To test the hypothesis that the reduction in gonadal function can lead to bone mass loss, a group of 12 men who had undergone bilateral orchidectomy at the age of 28.2 +/- 6.8 yr was evaluated. A progressive loss of the lumbar bone density was observed as a function of time after orchidectomy. Both the biochemical indices of bone resorption (urinary hydroxyproline/creatinine ratio and plasma tartrate-resistant acid phosphatase) and bone formation (serum osteocalcin and bone isoenzyme of alkaline phosphatase) were significantly increased in the patients compared with healthy controls. A positive correlation was found between urinary hydroxyproline excretion and percent change in spinal bone mineral density per yr. Because of this increase in the biochemically indicated bone resorption, nine of the patients were studied again after 1-3 yr and were thereafter treated with intranasal calcitonin. Urinary hydroxyproline excretion normalized after 3 months of treatment, and a significant decrease, but not to normal levels, was also observed in the mean values for the other biochemical indices of bone remodeling. Thus, testosterone deficiency, like estrogen deficiency, is associated with accelerated bone loss. The increase in osteoresorption was partially corrected by calcitonin treatment.
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Feel free to post copies (not links) or other summary (short) studies that you might find that document the effects of surgical castration. (Include the link too for validation, but not just the link as links do get old).
For those who want to be surgically castrated, such information should be considered before making an intelligent informed educated decision to prevent one's balls from doing your thinking for you. Sometimes I think balls have self-destruction tendencies and are suicidal and they take over our thinking process and we whack them off before realizing what a complex role they have in our body. There is a lot more to them than just semen and testosterone and sex drive.
PS: Post studies done only on humans. Studies on rats etc. are not conclusive. Thanks.
Study #1: Confirmation of what we know. Eunuchs not receiving supplemental testosterone will experience actual bone loss, the effects of which are not discussed here.
http://lib.bioinfo.pl/meid:224717
Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling.
[My paper] J J Stĕpán, M Lachman, J Zvĕrina, V Pacovský, D J Baylink
Department of Medicine 3, Charles University Faculty of Medicine, Prague, Czechoslovakia.
To test the hypothesis that the reduction in gonadal function can lead to bone mass loss, a group of 12 men who had undergone bilateral orchidectomy at the age of 28.2 +/- 6.8 yr was evaluated. A progressive loss of the lumbar bone density was observed as a function of time after orchidectomy. Both the biochemical indices of bone resorption (urinary hydroxyproline/creatinine ratio and plasma tartrate-resistant acid phosphatase) and bone formation (serum osteocalcin and bone isoenzyme of alkaline phosphatase) were significantly increased in the patients compared with healthy controls. A positive correlation was found between urinary hydroxyproline excretion and percent change in spinal bone mineral density per yr. Because of this increase in the biochemically indicated bone resorption, nine of the patients were studied again after 1-3 yr and were thereafter treated with intranasal calcitonin. Urinary hydroxyproline excretion normalized after 3 months of treatment, and a significant decrease, but not to normal levels, was also observed in the mean values for the other biochemical indices of bone remodeling. Thus, testosterone deficiency, like estrogen deficiency, is associated with accelerated bone loss. The increase in osteoresorption was partially corrected by calcitonin treatment.
..................................................
Feel free to post copies (not links) or other summary (short) studies that you might find that document the effects of surgical castration. (Include the link too for validation, but not just the link as links do get old).
For those who want to be surgically castrated, such information should be considered before making an intelligent informed educated decision to prevent one's balls from doing your thinking for you. Sometimes I think balls have self-destruction tendencies and are suicidal and they take over our thinking process and we whack them off before realizing what a complex role they have in our body. There is a lot more to them than just semen and testosterone and sex drive.
PS: Post studies done only on humans. Studies on rats etc. are not conclusive. Thanks.