Androcur for the Post-Op TG

[Tracy1980 (imported)]

I have my GRS coming up, which means that in this surgery, my testes will be removed; hence, also the major T-producing factory.

However, my body was very sensitive to T, and I have read studies that said some post-op TG's should continue to take their Androcur pills, as T will still be produced by the adrenal glands.

Here is my question. Would the Androcur still be effective on adrenal T? Also, if I continue to take the Androcur post-GRS, what dosage should I take it as? I am currently taking 200 mg daily as a pre-op. What dosage should I take as a post-op?

Tracy

[kristoff]

I have my GRS coming up, which means that in this surgery, my testes will be removed; hence, also the major T-producing factory.

However, my body was very sensitive to T, and I have read studies that said some post-op TG's should continue to take their Androcur pills, as T will still be produced by the adrenal glands.

Here is my question. Would the Androcur still be effective on adrenal T? Also, if I continue to take the Androcur post-GRS, what dosage should I take it as? I am currently taking 200 mg daily as a pre-op. What dosage should I take as a post-op?

Tracy

The first thing is to speak with your doctor for the best advice. Keep in mind that Androcur does not stop testosterone from working. Instead it stops the production of testosterone by the testes by blocking the function of GnRH. Hence, no nuts, nothing to disrupt.

[Tracy1980 (imported)]

If that if true, then why do some genetic women who suffer from excessive body and face hair growth and loss of hair on scalp take Androcur? Some of them will take as much as 50 mg per day. They have no testes as well, yet they still take the Androcur.

[mrt (imported)]

Because it also stops its production from working Ovaries. Ovaries produce most of the testosterone in women btw.

[Tracy1980 (imported)]

I posted the same question on another site (As a post-op, will taking cyproterone (aka androcur), block the production or effects of andrenal T?), and this is what another post-op TG had to say to my answer. Let me know what you think.

The short answer is "Yes." To explain: The source of the Testosterone doesn't matter, T is T regardless of whether it originated in the testicles or adrenal glands or a syringe for that matter. Your body doesn't care where the T came from, and neither does the Androcur, the action will be the same.

"Adrenal T" is only made indirectly. The adrenal glands produce two different Testosterone pre-cursors: Androstenedione and DHEA, which can be converted into both androstenedione and androstenediol; both of which can subsequently be converted into testosterone, which can be converted into DHT. That said I should also point out that androstenedione can be converted into estrone and testosterone into estradiol via the aromatase enzyme found in adipose (fatty) tissue. What that means is an overweight person is going to have increased aromatase levels converting a portion of androgens into estrogens, which would mean they should require lower doses of anti-androgens.

If you're curious about this "hormone chain" and how all these things interact with one another take a look at this page. If you're trying to interfere with the action of a given hormone the closer to that hormone you are in the chain the more effective the treatment as it reduces the number of variables (conversions) in between. Put more simply, if you are trying to block DHT either prevent it's formation by blocking 5-AR, blocking T receptors with androcur, or block DHT hormone receptors with Spiro.

So, according to her answer, if I am sensitive to the effects of T and its DHT derivative, it may be a wise choice for me to continue the Androcur post-GRS. Now, I am taking 200 mg daily as a pre-op, but maybe taking just 50 mg daily as a post-op would be effective. What do you think? What could be the disadvantages of doing this?