stillgettinghard22 (imported) wrote: Tue Oct 12, 2010 1:37 pm It's great to hear that so many men have had success in taking control of their testicles with such a simple procedure

It looks like the medical researchers are also investigating this same procedure as an alternative to surgical castration in advanced prostate cancer. Here is one reference, note they are also looking at Glycerol injections - anyone tried that??

Percutaneous orchiectomy: A noninvasive method of castration beyond percutaneous testicular sclerosis. (http://www.asco.org/ASCOv2/Meetings/Abs ... ctID=33625)

"Abstract:

Background: Surgical castration is the gold standard for hormonal deprivation in metastatic prostate cancer, nevertheless this simple procedure may involve on psychological consequences. According to many studies, it's possible to achieve ischemic lesion in liver tissue beyond sclerosants agents (like alcohol or glycerol), however there are very few reports about the effects of such agents in testicles. These study objectives evaluating histological and morphological characteristics of rat testicles submitted to percutaneous administration of sclerosants agents and also, to compare serum testosterone levels between rats submitted to a surgical orchiectomy or percutaneous injection. Methods: Twenty four rats have been shared in four groups with eight animals each. In group O, rats were submitted to bilateral orchiectomy. In the other groups, rats were submitted to percutaneous administration of a sclerosant agent and orquiectomy after thirty days as follows: Group A, Alcohol injection; Group G - Glycerol; Group S - Saline solution (control group). Serum testosterone level was measured after 15 and 30 days in each animal. Results: There is no complication or death in this series. Rats of groups A and G comparing to control group (group S) had smaller testicular weight (0,8±0,1g ; 1±0,2g versus 3,15±0,1g p<0,0000001) and smaller testicular volume (0,16±0,05mL; 0,23±0,11mL versus 2,38±0,05mL p<0,0000001). Testosterone serum levels were as similar in groups A and G (sclerosis) as in group O (orchiectomy). After 15 days testosterone levels were A=2,9±0,74 ng\/dL; G=2,8±0,39 ng\/dL versus O=2,91±1,46ng\/dL p=0,99; and after 30 days were A=2,58±0,4ng\/mL, G=2,78±0,3ng\/mL versus O=2,7±0,95ng\/mL p=0,895). Histological findings show extensive necrosis beyond macrophagic infiltration and no Leydig cells visualized.There is no significantly statistical difference between Alcohol and Glycerol groups. Conclusions: Percutaneous administration of alcohol or glycerol in rats testicles causes atrophy and reduces testosterone serum levels like it occurs after surgical castration. More studies are necessary to evaluate if this minimally invasive procedure may be an alternative to surgical orchiectomy in advanced prostate cancer."

OK....first round of injections is done.

For the record: 1.5cc's = 1.5 ML's.

Not much trouble getting the needle in.

Here are a couple tips and follow them religiously:

1) Breath out when pushing in with the plunger.

2) Go slowly. You see those little marks on the side of the needle? Go about half of one of thoses on every push.

3) *PAY ATTENTION HERE!* Do not, I repeat, do NOT inject until you feel pain and then stop. There is a delay between when it's to much and when you feel it. If you decide to not stop pushing until you feel the pain you'll get that initial pain PLUS the stuff you didn't feel right away.

I learned that one the hard way and thought I'd save you the trouble.

Pain with my stomach like I've been slapped in the balls a few times and some in my lower back, though I don't know how much of that is from the injections and how much is from being hunched over in a sitting position.

Hardest part of going slow - and you HAVE to go slow - is holding the needle still while injecting. Everytime you move it, you'll feel it.

I DID get 1.5cc's into each one and I'll not inject again for two weeks. I probably wont see any appreciable results yet, but it feels better knowing that I'm on my way.

a90 (imported) wrote: Sun Feb 06, 2011 4:25 pm It looks like the medical researchers are also investigating this same procedure as an alternative to surgical castration in advanced prostate cancer. Here is one reference, note they are also looking at Glycerol injections - anyone tried that??

Percutaneous orchiectomy: A noninvasive method of castration beyond percutaneous testicular sclerosis. (http://www.asco.org/ASCOv2/Meetings/Abs ... ctID=33625)

It was because of this experiment and many others, that I decided to try the procedure. If you do your research you will find that they had a very low complication rate on all experiments, and most (one paper I read did not get good results) had results equal to surgical castration.

raynestorm (imported) wrote: Sun Feb 06, 2011 4:59 pm OK....first round of injections is done.

<snip>

3) *PAY ATTENTION HERE!* Do not, I repeat, do NOT inject until you feel pain and then stop. There is a delay between when it's to much and when you feel it. If you decide to not stop pushing until you feel the pain you'll get that initial pain PLUS the stuff you didn't feel right away.

I learned that one the hard way and thought I'd save you the trouble.

Pain with my stomach like I've been slapped in the balls a few times and some in my lower back, though I don't know how much of that is from the injections and how much is from being hunched over in a sitting position.

The first was the worst, in my experience. For the second and later injections, nervous tension isn't so great, experience is working for you, and the testicles themselves have already handled the initial worst shock. Good luck, and please keep us informed.

I've read how some people here got 'addicted' to doing this and I can't figure out for the life of me HOW.

The first testicle I rushed a bit because I didn't know better and sometimes the pain was so blinding that I almost past out. That's when I learned about the delay.

Second testicle I went much, much slower and it didn't hurt as bad but I was glad when it was over.

I'm still a little sore today and I'm glad I'm off today and tomorrow.

raynestorm (imported) wrote: Mon Feb 07, 2011 7:48 am I've read how some people here got 'addicted' to doing this and I can't figure out for the life of me HOW.

My last injection was very painful. I either pulled a muscle in my abdomen doing or had done so prior to the injection. I don't really know.

Anyway, it threw some cold water on doing it again. Before then, I was always looking forward to my next injection.

I was wondering the same thing. Guys have often said that after a few injections, their testicles start feeling good. Warm, tingly, and heavy feeling they claim.

Is this a myth, or is it true?

I wouldn't know, because my left testicle was numbed with lodocaine before it was injected with everclear.

Yes, the feeling of warmth and fullness is real. Numbing the testicles with lidocaine is not advised, precisely because it prevents you from feeling what's happening as you inject.

Again, I have only noticed the "warmth" once, I think it's one of those YMMV things, and yeah, people have said bad things about what happens when you numb the testicles prior/during. I used to numb the scrotum with anbesol before injecting, but when I switched from a 25 g to a 29 g needle, I noticed I don't really have any problems injecting without a numbing agent. As far as addiction, I don't know if it's a real addiction or if it's just a large drive to be done with them, for myself, I really don't like injecting, but I look forward to the next one each time because it makes me happy knowing someday soon, I won't be burdened with them anymore. I'd like to start on hormones sometime soon, but I don't want to tip the doctors off that I've done something intentional so I'm just waiting my time impatiently One thing that has helped me curb the urge to inject more frequently is to only inject 1 testicle at a time, still waiting for the tenderness in the left one to go down some before I do the next injection, was hoping for today, but still a bit tender to make the attempt, maybe tomorrow.

Hrm, left one is getting to be tough to inject, tenderness was down, but I only managed to get .2cc in before the ache of fullness took over, I'll try one more time next week, if I can't get much more into it, I'm just gonna let it be for a few weeks and see what happens.