All of this truly begs the question of whether or not the PC issue is genetic or not. If it is, how far can we go to prevent it's taking shape or recurring. I've never had a doctor tell me that I have a risk of PC. But also I have no testosterone production left in my body to speak of. Well of course there is some not a result of testes. We all have some production whether we like it or not. Even females have some production or conversion of hormones to "T". Granted, the way I have abused estrogen over the years my body doesn't have much "T" to rail against in the form of PC. I still have the prostate and enjoy what it does for me. So to answer the question: I am not worried about prostate cancer.

Being totally paranoid about it, as my father, his brother and his nephew all died of prostate cancer and all within 9 months of first symptoms, it seems that as long as you have a prostate you can get cancer in it. Only after cancer has appeared will castration maybe have an effect. If you have a prostate you should have it checked. Unless of course someone knows differently.

I am little puzzled by general doctors approach that they don't do anything preventive until cancer is there. Like watching PSA to rise to treshhold. PSA will never drop by itself, it is only question of time when threshhold level is exceeded. Would the recommend intermittent testosterone deprivation therapy? No. In my case PSA dropped about 10x... And so chances to get cancers did drop too. Well, I am not so great fan of libido either, but doctors should give correct information about loss of libido and not amplify that sentiment that loss of libido is very bad or life changing or making one less a man.

So at the current moment I have absolutely no Prostate cancer worries as I have been chemical eunuch for 3.5 months

Cseriess (imported) wrote: Fri Sep 06, 2019 11:03 am If you don't mind me asking, what kind of size effects are you having on estrogen? Also a high risk here, my biopsy was clear after a 11 on my last PSA. I had 3 in a row that kept escalating from an 8. Could not convince my urologist that we should consider a prostatectomy now and not just wait for the cancer to arrive. Very frustrating.

PSA is an imperfect metric. It is increased by a variety of factors, including size (BPH), infection, inflammation, and maybe more. The only way to know is by biopsy. You might look for an MRI-guided biopsy, since the normal 12-core random biopsy can miss things. Imagine a lemon has maybe 3 seeds randomly scattered inside, and you poke it with a needle 12 times. What are the odds of hitting one of the seeds? Unless the little tumors are pretty good size, they can be missed. However, if they're that small then maybe they're not a big risk.

Try plotting the PSA values you have by their dates, and look for a logarithmic trend. Biological processes are usually linear on log plots, so if you see that it's suggestive of a concern.

Prostatectomy can seriously compromise your quality of life, mainly incontinence and impotence. Incontinence is quite a burden to live with. Doing it to potentially prevent cancer is a tough sell, due to the side effects. The side effects are more tolerable if the alternative, an actual cancer, is worse. But to do that to an otherwise healthy individual is something a surgeon is unlikely to do.

To your question, the estrogen side effects are minimal to me so far. Of course I welcome the elimination of libido, and also sexual ability. My breasts are a little tender now, though nothing visible is happening after 3 months. No fatigue, no hot flashes, and we'll just have to wait to see any bone density effects (should also be ok, my blood estrogen level says I'm at the minimum to protect the bones).

Cseriess (imported) wrote: Fri Sep 06, 2019 4:43 am Transgender males still get prostate cancer after transition if they have a prostate. Castration as an adult does not prevent PC, however, once it's there, castration, chemical or surgical can stop its growth.

I think the question is what, if any, protection occurs when males transition at a certain age. E.g., does somone who transitions at 25 have a lower risk of eventually developing prostate cancer than someone who transitions at 55, and if so, how much lower?

Bentboi22 (imported) wrote: Fri Sep 06, 2019 5:01 pm I think the question is what, if any, protection occurs when males transition at a certain age. E.g., does somone who transitions at 25 have a lower risk of eventually developing prostate cancer than someone who transitions at 55, and if so, how much lower?

Not sure there have been enough educational data provided to give an accurate response to that question. If there has been they're keeping it to themselves. My healthcare providers take very good care of me and have checked my prostate annually along with normal quarterly labs. I was castrated at around 36 yrs of age. I'm now 61 so if we assume I'm about the norm in regards to those castrated we have a small sample to compare to. My healthcare providers tell me I have no indicators of any kind of PC. I've been taking "E" for all but a couple of those years. And never took any "T" of any sort.

I'm guessing you're at low risk considering the age at which you transitioned, but in the absence of scientific evidence (of which we're aware), who really knows? Results can be paradoxical . . . or T deprivation resistant cancer cells might prosper in the absence of non-resistant cells (the basis I think of intermittent testosterone blocking therapy for advanced prostate cancer).

cutnbulls2ox (imported) wrote: Fri Dec 14, 2018 8:39 pm Cseriess started a very interesting post on prostate cancer. His post is named Irritated by gender inequities. Its about preventive early castration to prevent prostate cancer.

It makes me wonder how many men have family histories of prostate cancer that cause them to think about castration as either a surgery they will likely have some day when they are older. Or wonder if early castration might help prevent prostate cancer for men with higher risk of getting it since they have many male relatives or family members who had prostate cancer ?

Lots of us likely will be chemically or surgically castrated for prostate cancer as we age.

Is that a big reason for men on here being interested in learning more about castration and how it changes and affects men ?

Will back to the topic then!

I will have to read the post by Jesus again that had some info about age of castration and its efficacy on prostate cancer

Did it? I must have missed it, thought I looked at the references but maybe that was the wrong post?

I can't actually find the post by Jesus, but I thought it said after a certain age, the prostate grows into its adult stage, and castration after that does nothing to prevent cancer. Castration can only stop or slow cancer once it has startedand only if it's not castration resistant. If you find it, would you post it, I would like to read it again. Thanks.