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Re: New gene found that determines physical sexuality

Posted: Thu Dec 17, 2009 11:22 am
by Mac (imported)
SplitDik (imported) wrote: Tue Dec 15, 2009 3:25 am This is interesting. They've found that it is not just the XY chromosomes that can determine if you become physically male. May have some implications for therapy for transgender or hermaphroditic situations.

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SplitDik (imported) wrote: Tue Dec 15, 2009 3:25 am December 11, 2009

Scientists find single ‘on-off’ gene that can change gender traits

Hannah Devlin

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SplitDik (imported) wrote: Tue Dec 15, 2009 3:25 am The researchers anticipate that temporarily suppressing SOX9 in males would have the opposite effect. Turning it off would automatically trigger the ovary development gene to come on, leading to cells in the testes turning into follicles and ceasing the production of testosterone.

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If that is true I would like to get my SOX9 turned off.

Re: New gene found that determines physical sexuality

Posted: Thu Dec 17, 2009 11:23 pm
by gareth19 (imported)
Hash (imported) wrote: Wed Dec 16, 2009 5:21 am Controlled by creationists? If you think evolution is actual science then explain complexity & entropy? My problem with evolutionists is that they assert or postulate that after life occurred in the primeval swamp, that these single celled creatures were able to determine their need to see, their need to hear, their need to smell, so they developed these specific organs with their cognitive abilities. If you can explain how single celled amoebic creatures could develop complex organs that would enhance their sensory abilities without any outside intervention, then I'd accept evolution. If I could think and determine through the process of thought what I'd like to have and obtain it or develop it, I might grow myself a bigger penis, I might regrow my testicles and scrotum, I might actually grow two penises. But alas, no one has this ability and no single celled creature was able to think and make the decision as to what it needed and then cognitively make it come to pass. There had to be outside influence and there was. Notice I didn't mention a creator or God. So before you postulate that creationism is impossible or implausible, I'd suggest you study complexity. Humans alone are so complex that evolution pales in light of the unique features of man. Study the Second Law of thermodynamics, or the Law of Increased Entropy (law meaning it's a fact unlike evolution). The Law of Increased Entropy states that matter/energy deteriorates gradually over time. If evolution is true, then the Law of Entropy is wrong, and it isn't. Please educate yourself.

Apparently you don't understand entropy which has nothing to do with phylogenetic complexity but rather is a statement of thermodynamic randomness, and your misunderstanding of the concept indicates you've far less quantum physics and thermodynamics than I've had. And if you really do think that the Second Law of Thermodynamics trumps Darwin you must also hold, unless you are completely illogical in your "thinking," that creating men out of mud would also violate your misunderstanding of the Second Law of Thermodynamics and disprove the existence of God as well. What's sauce for the goose, alas, is also sauce for the gander; any half-witted attempt to discredit Darwin will also destroy Christianity because the Bible is full of silly prohibitions (no pork, no shell-fish, no foreskins, no fags, no wool-cotton blends) that most Christians blithely ignore with the comfort that the New Testament permitted a reshuffling of the Old Testament rules (except for a special few whose application can be used to irritate others). Because Christianity claims to have evolved from an earlier Judaism, any attack on evolutionary thought is an attack on the basis of Christianity itself. Only atheists and morons believe in special creation; the truly religious are as appalled by "creation science" as they are by the Black Mass and for the same reason: they are both the Devil's handiwork as shown by the fact that they are, like Your Father Below, so imbelic in conception.

The key to Darwin's great synthesis is what he called "pre-adaptation." No organism "wills" itself to see, to live on land, to fly or any other adaptation. It is dealt those properties by chance. Yes, the effects of genetic mutation are minor and inconsequential, but if you have billions of years and octillions of generations to play with, the cumulative effect will be significant. The katydids that look more like leaves will be harder to spot among the leaves and have a better chance of living long enough to meet another katydid and passing on that feature, and it is an indisputable fact that parents do pass on their genetic resources. Over time, the small advantage becomes significant. Photoreceptive cells occur inside of sponges and coelentrates; they don't seem to have any purpose, but they are clearly there; those organisms that came after the sponges and jellyfish that had more complex arrangements of photoreceptors had a better chance of avoiding predators, finding food and other activities which enabled them to pass on the improvement. By chance some developed a covering to protect the photosenstive cells which gave them an advantage over their more easily blinded brethren; chance variations in the coverings enabled them to focus light more effectively and so it went.

Re: New gene found that determines physical sexuality

Posted: Fri Dec 18, 2009 12:09 am
by Kortpeel (imported)
...
bobberlove (imported) wrote: Tue Dec 15, 2009 7:46 am the prospects of Earth's future being controlled by science is frightening to me.

Far more frightening is the prospect
bobberlove (imported) wrote: Tue Dec 15, 2009 7:46 am Earth's future being controlled by
ignorant/unscrupulous politicians who are skilled at playing on the emotions of even more ignorant people to further their own personal interests. This is the great weakness of democracy.

Science itself is merely a quest for greater understanding of ourselves and the universe in which we find ourselves. This is a noble objective. For example: isn't is better to know that a lightning bolt is merely a discharge of static electricity rather than think that the god Thor is throwing his toys out of the cot?

Kortpeel

Re: New gene found that determines physical sexuality

Posted: Fri Dec 18, 2009 5:37 am
by Dharkbus (imported)
Dave (imported) wrote: Wed Dec 16, 2009 7:34 pm You see, the problem with the argument that you are making is that life is so complex, it couldn't evolve from raw ingredients.

It is the old "complexity" argument that has been rejected by years of discovery by biologists, microbiologists and others dealing with living things.

We've heard it all before --

Eyes are too complex to evolve.

The tails of flagellum (or whatever they are called) couldn't rotate by nature methods. Therefore sperm and bacteria cannot move through fluids.

Even Thought is too complex to evolve.

And yet, science continues to prove how those things evolve and work. Eventually some scientist will discover how DNA formed from the primordial soup (as you call it). Then the argument against evolution will move to another aspect of life and that will be given as the reason for the raging failure of evolution.

There was an article recently about how feeding birds in our backyards changes their migration patterns and how they might evolve into the birds of the future. This happens over a period of tens of years. It is called evolution... It occurs in much less than man's lifetime.

http://www.livescience.com/animals/0912 ... ution.html

and yet this is not what I said at all. I never things where to complex to evolve, and I never said That dna couldn't evolve from a primordial soup. I said that no-one can prove that that is the manner in which we evolved. No-one can prove it because of the scientific method. For an experiment to be acceptable it has to be repeatable under the same circumstances. First no one can be certian how life evolved, if that's what you belive. second according to evolution it took millions of years to evolve, so if we said that the first organism took a thousand years to evolve (just a random nice number) from the soup then the experiment would take that long or longer.

Its like the big bang theory, it just cannot be proven because of the issue of time.

as for the article, I stated quite clearly how i didn't believe the fact that things change is evidence for evolution or against creationism. of course things change over time. Its evident all around us. It doesn't mean someone didn't put us here, or at the very least started this whole "experiment"

Re: New gene found that determines physical sexuality

Posted: Fri Dec 18, 2009 10:48 am
by BacchaeofCadmus (imported)
Hash (imported) wrote: Wed Dec 16, 2009 4:46 pm Trotted out the old creationist lies? What lie have a told? I tried to show that evolution is wrong and I'm a liar? Again an evolutionist who won't listen because he doesn't want to even consider that a creator could actually exist. Please open your eyes and your mind, complexity screams creator.

Hello. I regularly come to read stories at the Eunuch Archive but did not register for the forum until I was specifically disturbed by your posts in this thread, and will address all of them in this post.

In fact, complexity 'screams' evolution. At Darwin's time, a mechanical explanation for biodiversity was being sought after, and Darwin found it. The theory of evolution was specifically designed as an explanation for biodiversity and complexity.

You argument is old and is known from people such as Michael Behe, William Paley and Thomas Aquinas, and I can address the forms of this argument presented by all three of them.

Thomas Aquinas in his Summa Theologica wrote of five arguments in favour of God's existence known as the Five Ways. The fifth one is the teleological argument, although it being distinct from the other four in any way is dubious enough, but the explicit terms which match the argument you're referring to appear in the teleological argument. Teleology argues from the observation of complexity that there is a final purpose to existence, that the things in the universe are too well ordered, too beautiful, too complex, whatever word you want to assign, to have come into existence without a purpose and a first cause.

The teleological argument is nothing but an argument which contradicts itself in summary. "I have no explanation for the complexity, beauty and order of existence, therefor I can explain it." Saying a lack of explanation merits the explanation of a creator is merely a contradiction and does not merit consideration.

The other two forms share the exact same problem, also being teleological arguments. However, having their own take on it they add new problems.

William Paley in his work Natural Theology makes the same argument in the form of the Watchmaker Analogy. The watchmaker analogy again refers to complexity. It goes something like this, that if I were to come across a stone in nature and were asked to explain its origins I could with some plausibility argue that it had always been there, that it was simple enough not to have special purpose, but that if I had come across a pocketwatch that I could never argue that its intelligible purpose and complexity had come about at random, and that the universe shares this complexity, so as there must be a watchmaker, there must be a designer for creation. I will list the problems with this argument in numbered order;

1. This form of the argument presents another contradiction. The intelligence necessary to create something of complexity such as a pocketwatch is an intelligence demanded of something itself vastly more complex than its creation, a human being. Similarly, a creator would have to be itself vastly more complex than the universe, and by that token the creator suffers from the same deficiency the argument places on the universe, that it could not have come into existence by itself. The creator requires a creator, and that creator requires a creator, and this continues ad infinitum, providing no explanation for origin.

2. Pocket watches are clearly designed because they report the artificial human construct of time, and are actually not very complex in relation to nature.

3. Pocket watches do not reproduce and so the analogy does not work in reference to life.

4. The origin of rocks is not particularly simple.

Next comes Michael Behe who conceived of irreducible complexity, and coined the phrase 'Intelligent Design', which is no different than the previous two arguments except that it gives the example of the bacterial flagellum. Michael Behe argues that the bacterial flagellum, resembling an outboard motor, is composed of 'parts' with no independent function and that no assembly of the flagellum lacking any of the present 'parts' could function as anything else, making it impossible for it to have developed by means of evolution.

He is simply incorrect. The type 3 secretory system is a known assembly of the same proteins which is less complex.

So far I have merely established that you can not explain complexity. I shall now address your questions.

Entropy I can do away with in one sentence; the earth is not a closed system and so the second law of thermodynamics does not apply. If you would bother to go so far as to read even a wikipedia entry on the subject, you would not bring it up.

First I should clear you up on some elementary classifications in science so that you don't sound ridiculous. The 'occurrence of life in the primeval swamp' is the theory of abiogenesis, which is born of organic chemistry, a different discipline than biology which is where the theory of evolution comes from. Do not confuse them.

Then I must inform you that you don't understand anything about evolution. The 'will' of early organisms is irrelevant; it does not exist, such a notion is not even entertained in the theory of evolution.

What you must know is that all living things are composed of DNA, and that DNA replicates. It is our function to replicate our DNA, it is the function of every living thing on earth. In the replication of DNA there are sometimes errors, and your assertion that mutations do not result in productive change is simply incorrect. They result in slow change, but often productive, and this is known to be true by empirical observation. The change isn't even as slow as you might say in your rhetoric, eyes as we know them can develop in the conservative estimate of around 250,000 years.

I don't know why there is such flagrant ignorance in this country but it is the only means by which anyone could deny evolution. You must know that the process of evolution, even speciation, has been observed to occur. We know for a fact that evolution occurs.

You are in need of an eduction if you believe that over a million published, peer reviewed scientific papers on the subject of evolutionary biology in the past 150 years were crafted with an ignorance of physical laws you can cite with no education in the sciences. There is no debate, as far as any honest mind is concerned the debated ended in 1859 with Charles Darwin's publication, but since then the amount of additional evidence is overwhelming and does not come merely from the discipline of biology.

The discovery of DNA was irrefutable evidence of the accuracy of evolution, if you do not understand this then you need to be further educated. All living things on earth are composed of DNA, meaning that all living things on earth have a common ancestor. There is no argument against this.

Re: New gene found that determines physical sexuality

Posted: Fri Dec 18, 2009 11:43 am
by SplitDik (imported)
Well, my topic has certainly gone off topic!!

But it is interesting nonetheless. Regarding evolution, I wholeheartedly view everything in life through its lens. If you think about it, the whole Eunuch Archive is sort of proof that things probably weren't created (by the Christian traditional creator definition) -- why would God create transsexuals, hermaphrodites, even homosexuals if they are presumably against his design? I realize that is not solid logical proof, but to me it debunks the traditional view of God's design as put forth in the Bible.

Anyway, I agree that pretty much everything we do is driven by biological imperatives, and that those imperatives were shaped by evolution. Why do we (most of us) want sex? Why do we want family? Why are we vain, greedy, aggressive, etc.? All these make perfect sense in an evolutionary context.

The only thing I would say though is that science doesn't satisifactorily explain the *experience* of being alive. We may be just a complex collection of self-replicating matter that follows physical laws of nature, however it certainly feels like we have a Free Will. I don't think the monotheistic religions really solve this satisfactorily either, but I understand the need to explain the *experience* of living in addition to the mechanics of living.

If I were religious, I would have to still believe in evolution even if I felt there was a Creator, because the evidence is just too overwhelming in favor of evolution. To not believe in dinosaurs (and other fossil records), to not believe in breeding and natural selection, to not believe in DNA mutation, when any of us can go out and see that evidence right before our eyes, I think is pretty untenable to any critical thinker.

Re: New gene found that determines physical sexuality

Posted: Fri Dec 18, 2009 10:32 pm
by lisarenee (imported)
Long time reader, first time poster here. I registered yesterday specifically to address the comments of Dharkbus because of the striking ignorance he showed of the scientific principals he was citing. I see that others have beaten me to it though, specifically gareth19 and BacchaeofCadmus. I do still have my own thoughts to contribute though.

Let me digress for a moment to say that I do not mean to use the term "ignorance" in a pejorative manner here. I mean it in the literal sense, in that it seems that Dharkbus simply does not understand the concepts to mean what they actually mean. There's no sin in that, just a need for a bit of education, and education is always a good thing.

Gareth covered Thermodynamics quite well, though I'll touch on it a bit as well. What really caught my eye though was Bacchae's statement of "
BacchaeofCadmus (imported) wrote: Fri Dec 18, 2009 10:48 am In fact, complexity 'screams' evolution
", which leads me to believe that perhaps Dharkbus is not using the same definition of "complexity" that gareth, Bacchae, and myself are using. I'm sure Bacchae, who clearly has some education in philosophy, would agree that before any rational conversation can take place, we must first define the terms we are using.

Behe's definition of "irreducable complexity" is not the same as the scientific concept of complexity. I won't go into refuting Behe, because that has already been done. I would like to take a moment to define what the gareth, Bacchae, and myself mean when we reference "complexity" in the context of evolution, specifically the concept of Complex Adaptive Systems.

I'll let john Holland, one of the people who first coined the phrase at the Santa Fe Institute back in the mid '80s, give you his definition;

"A Complex Adaptive System (CAS) is a dynamic network of many agents (which may represent cells, species, individuals, firms, nations) acting in parallel, constantly acting and reacting to what the other agents are doing. The control of a CAS tends to be highly dispersed and decentralized. If there is to be any coherent behavior in the system, it has to arise from competition and cooperation among the agents themselves. The overall behavior of the system is the result of a huge number of decisions made every moment by many individual agents. A CAS behaves/evolves according to three key principles: order is emergent as opposed to predetermined (c.f. Neural Networks), the system's history is irreversible, and the system's future is often unpredictable. The basic building blocks of the CAS are agents. Agents scan their environment and develop schema representing interpretive and action rules. These schema are subject to change and evolution."

Now that is about as good a definition of CAS as you could ask for. Order emerges naturally out of chaos. CAS is evident everywhere in the universe, from the atomic scale to the galactic, and it shows that there is no need for a "Prime Mover", as Aristotle would put it. Additionally, it is directly in line with
gareth19 (imported) wrote: Thu Dec 17, 2009 11:23 pm the Second Law of Thermodynamics,
which also says that order emerges from chaos. Energetic systems, which are by nature chaotic, run down, they peter out until all that remains is an orderly field where not part (or point) has any more or less energy than any other part.

CAS can be pretty difficult to get your head around, but when it finally "clicks", everything makes sense. We live in a world of systems composed of individual actors, and those systems grow, change, and adapt based on the actions of the other systems they interact with, just as the individuals within a system grow, change, and adapt based on the actions of other individuals within the system, which in itself changes the system. This is directly in line with evolution and is a proven scientific reality. It is a bedrock principal of how the universe and all the life in it works, and it shows, as I said before, that there is no need for a Creator.

If anyone would like to further understand complexity and CAS, I would strongly recommend reading Complexity: The emerging science at the edge of order and chaos by M. Mitchell Waldrop. It is perhaps the finest primer I have found on the subject of complexity, and it will definitely open your eyes to just how amazing, yet perfectly natural, the world and universe around us is.