Thanks for the advice guys, I’m aware that Androcur is a powerful medication and can be dangerous when taken without proper medical supervision.

Whilst I’m ‘self medicating’ at the moment, I am being monitored very closely by my GP for any signs of trouble, and since starting in February I have had my liver function tested twice, two full blood counts, a kidney function test, my testosterone level of course, and one or two other things my GP wanted to check just to be on the safe side.

Before I started my therapist arranged for me to see a psychiatric doctor who has many transgender patients and understands hormones and the medications involved. Her advice to me was to start Androcur at 50mg a day (I was originally going to take 100mg), but that it was okay to up the dosage to 100mg a day if necessary for a fairly short period of time, months not years, but aim to come back down to a 50mg ‘maintenance’ dose as soon as possible to reduce the risk of liver damage.

After my next visit to my therapist I’m being transferred into the care this psychiatric doctor as part of the long winded process of being referred to an NHS endocrinologist who can take over my care (if they agree to taking on a patient who wishes to be chemically castrated without starting transition), and write the necessary prescriptions so I don’t have to self medicate… So I shouldn’t be short of professional advice - and I will of course pass on any useful information…

If and when I do get professional care from an endocrinologist it wouldn’t surprise me if they recommend entirely different anti-androgens to the Androcur and Tamoxifen which I’m taking at the moment. But for the time being I’m going to stick with them, and I think that now is the right time to increase my Androcur dose for a little while to get my testosterone level back down again before it creeps up any higher.

Also I think that as this is very much a trial run at the moment, it’s important that I try to keep my testosterone at castrate level for a reasonable period of time before I commit to taking things further. It’s a big ask to persuade the NHS to chemically castrate me, and I think that I really need to know what I’m letting myself in for before I commit. Sure, I can back out after I start to receive their help, but I think it would then be difficult to get the same help again at a later date.

Brain tumors were found in 36 cases of taking high amounts of cypro - ≥25mg. There is a confirmed association between meningiomas and long term high dose cypro usage. New studies are occurring to find association between high dose/meningioma and long term/meningioma.

Liver damage isn't the only thing you should be worried about. https://www.gov.uk/drug-safety-update/h ... eningiomas

Most users of cypro after 6+ months can continually lower their doses even to 6.25mg and less per day while maintaining low testosterone, but that is with the aid of estrogen.

Thanks for the link.

It does clearly state that the 36 cases of meningioma worldwide were patients who had been treated with cyproterone acetate from 4 to 27 years, and none of them were fatal.

Like many medications the list of potential complications once you get into the 1 in 1000 or 1 in 10000 people is rather alarming, and even the more common ones aren’t great!

Which is why I’m getting as much professional medical advice as possible, and will hopefully see an endocrinologist in the not to distant future.

Incidentally Tamoxifen, the other medication I’m self medicating, has a 1 in 10 chance of causing cataracts when taken for five or more years (according to a few studies), which is positively frightening! But the alternative medication I could take to reduce the risk of osteoporosis and gynecomastia, Raloxifene, isn’t recommended for patients with a history of high blood pressure, which I have, and can cause all sorts of nasty complications.

When I do see an endocrinologist I’m going to have a lot to discuss!

But in the mean time I’m not losing any sleep over taking 100mg Androcur a day for a short period of time, which I have been advised by a doctor is okay. The intention is to keep my testosterone at castrate levels with the lowest maintenance dose possible, so it won’t be long before I drop back down to 50mg and then perhaps 25mg it my testosterone stays low.

I’m trying not to ‘off’ myself by mistake!

I had a prolactinoma. My nipples started to drop milk. I can´t assure If was androcur , depo provera, estrogens,..etc.. what makes me to develop the prolactinoma. Probably was multi-factorial. In my familiy there´s no case of prolactinoma. just me

Week 12 - 3 months in!

Nothing exciting to report I'm afraid I might start making these monthly updates from now on....

Since shaving, my body hair is growing back mostly the same as before I think. Maybe a little slower?

im thinking maybe after 6 months I'll drop down to 50mg daily.... because right now, even on 100mg I don't find it difficult to get hard or horny D: maybe there's something else I can do to help with that?

Havent noticed any further ball shrinkage either

I'm not sure if I'm noticing it because I want to notice it (aka placebo effect!) but maybe my chest hair is growing back slightly less prickly..

Week 13

Business as usual this week! I 'think' my body hair is growing back slightly softer than before. It certainly feels less prickly on my chest.. so I hope that continues!

i still find it relatively easy to get hard and cum... but I guess upping the Androcur dose to 150mg daily would be pointless as my testosterone level is already way below castrate level.... I wonder what else I could do to kill my boners? Any suggestions? Maybe introduce a small amount of estrogen?!

My mental state continues to be pretty positive! I still can't be sure what exactly is the cause... but I'm think my testosterone level may have something to do with it!

My sexual fantasies have returned intermittently, so I just started back on Androcur at 100 mg/day, this time knowing how much I'll enjoy being rid of sexuality.

thinking that androgen deprivation will ride off all of your libido, sex drive or fantasies is a common mistake. They won´t NEVER dissapear completely, no matter what you do. The brain it´s a machine that constantly produce fantasies and images and processes etc. Androgen deprivation may reduces fantasy signifcantly but not will no eliminate completely. I have realised that when I have tons of work my mind rid of fantasies and my libido decreases.

Frida G Cavic (imported) wrote: Tue Jul 10, 2018 7:31 am thinking that androgen deprivation will ride off all of your libido, sex drive or fantasies is a common mistake. They won´t NEVER dissapear completely, no matter what you do. The brain it´s a machine that constantly produce fantasies and images and processes etc. Androgen deprivation may reduces fantasy signifcantly but not will no eliminate completely. I have realised that when I have tons of work my mind rid of fantasies and my libido decreases.

I'm a neuroscientist, so I do understand that the brain is complex. I'm simply talking about my experience with Androcur. In my case all sexual urges, thoughts and fantasies disappeared. Reading accounts on this site, you'll see how differently people react to the same drug. As they say, YMMV.