DeaconBlues (imported) wrote: Mon Jun 08, 2009 4:50 pm Several YEARS ago, I found the "Gonex" website, and it seemed that FDA approval was just around the corner... WHAT HAPPENED?!
Gonex was a SINGLE INJECTION that would cause permanent and irreversable castration. Primarily it would be used for animals, every animal, dog, cat, beef cattle, and yes, it would work very well for humans as well.
Gonex was supposed to permanently block the receptors on the pituitary gland, to "trick" it into behaving as though there was an excess of testosterone even if there were no testosterone. In laboratory animal trials, the effects were quick, painless, and as simple as a single injection. Once in the bloodstream, the active ingredient would go to the pituitary gland, and mimic testosterone, but permanently remain there, so that the "GNRH" (gonadotropin releasing hormone), the chemical messenger that turns on or off the testicles production of testosterone, would never be released.
It SEEMED to me to be an infinitely better way to castrate people or animals, so WHY hasn't this method of castration "taken the vet community by storm" or been used by urologists treating testicular cancer?
All the other methods discussed here, lactic acid, crushing, even surgical removal, seem crude and even cruel if this single injection method could work... What ever happened to this promising and interesting drug?
There are several GnRH inhibitors on the market, and some GnRH vaccine trials going on. Gotta have nuts to make them work; without them, don't need it....