LH-RH Zoladex LA 10.8mg Implant

Jean Op den Kamp (imported)
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LH-RH Zoladex LA 10.8mg Implant

Post by Jean Op den Kamp (imported) »

Yesterday I visited my urologist. My first problem, my foreskin....He agreed with my family doctor, called it lychen and put me on the operation list.

In about 6 - 8 weeks I am going to pray in a Jewish way...

My castration questions.............

He agreed that with 250 mg/day cyproterone acetate (Androcur) and waking up again several days with early morning erections (painful and painful), something is not working the way you should expect

He also agreed that with only about six weeks being happy on androcur, for not having erections nor ejaculations, we could not speak of a real time to try how it feels to become sexless

He offered another way......

LH-RH analoge Zoladex LA implant is not blocking the working from testosterone. It works on the hypophysis. First there will be a higher testosterone level, but then the production of testosterone will stop. After about two weeks the level should be near zero

I got that implant today by my family doctor, an injection at my abdominal wall some centimeter from my navel. (I keep the injection system for the EA museum if anyone is interested) As warned, it burns, but that feeling should go in a few days.

The 10.8mg implant should work three months. I intend to use this (if working) at least six months, to find out if I like the feeling. This also gives me time to arrange with the psychiatrist about my desire for real castration

For this moment, I can only tell that it burns when I move, and that I am a little afraid of the fact that my testosterone level might go up. I will continue to take the 250mg/day androcur for the first two weeks. It may protect a little (I hope)

I will keep you updated about the results. If nobody shows interest, my information will fade fade fade

I am very hopeful about this new way.

There is only one problem: Can you imagine a handful of small money???

Just for 1 injection?

That handful of dollars (usd) is what you get back from 1000 usd / injection

loveUall

Jean
kizahakan (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by kizahakan (imported) »

Some medidal info 4 the ones that might have interest about the implant....

ZOLADEX® (goserelin acetate implant), contains a potent synthetic decapeptide analogue of luteinizing hormone-releasing hormone (LHRH), also known as a gonadotropin releasing hormone (GnRH) agonist analogue.

INDICATIONS

Prostatic Carcinoma

ZOLADEX is indicated in the palliative treatment of advanced carcinoma of the prostate.

In controlled studies of patients with advanced prostatic cancer comparing ZOLADEX 3.6 mg to orchiectomy, the long-term endocrine responses and objective responses were similar between the two treatment arms. Additionally, duration of survival was similar between the two treatment arms in a major comparative trial.

In controlled studies of patients with advanced prostatic cancer, ZOLADEX 10.8 mg implant produced pharmacodynamically similar effect in terms of suppression of serum testosterone to that achieved with ZOLADEX 3.6 mg implant. Clinical outcome similar to that produced with the use of the ZOLADEX 3.6 mg implant administered every 28 days is predicted with the ZOLADEX 10.8 mg implant administered every 12 weeks.

Stage B2-C Prostatic Carcinoma

ZOLADEX is indicated for use in combination with flutamide for the management of locally confined Stage T2b-T4 (Stage B2-C) carcinoma of the prostate. Treatment with ZOLADEX and flutamide should start 8 weeks prior to initiating radiation therapy and continue during radiation therapy.

The automatic safety feature of the syringe aids in the prevention of needlestick injury.

DOSAGE AND ADMINISTRATION

ZOLADEX, at a dose of 10.8 mg, should be administered subcutaneously every 12 weeks into the anterior abdominal wall below the navel line using an aseptic technique under the supervision of a physician.

While a delay of a few days is permissible, every effort should be made to adhere to the 12-week schedule.

Prostatic Carcinoma

For the management of advanced prostate cancer, ZOLADEX is intended for long-term administration unless clinically inappropriate.

Stage B2-C Prostatic Carcinoma

When ZOLADEX is given in combination with radiotherapy and flutamide for patients with Stage T2b-T4 (Stage B2-C) prostatic carcinoma, treatment should be started 8 weeks prior to initiating radiotherapy and should continue during radiation therapy. A treatment regimen using one ZOLADEX 3.6 mg depot, followed in 28 days by one ZOLADEX 10.8 mg depot, should be administered.

Renal or Hepatic Impairment

No dosage adjustment is necessary for patients with renal or hepatic impairment.

Administration Technique

The proper method of administration of ZOLADEX is described in the instructions that follow.

1.Put the patient in a comfortable position with the upper part of the body slightly raised. Prepare an area of the anterior abdominal wall below the navel line with an alcohol swab.

2.Examine the foil pouch and syringe for damage. Remove the syringe from the opened foil pouch and hold the syringe at a slight angle to the light. Check that at least part of the ZOLADEX implant is visible.

3.Grasp the blue plastic safety tab and pull away from the syringe and discard. Remove needle cover. Unlike liquid injections, there is no need to remove air bubbles as attempts to do so may displace the ZOLADEX implant.

4.Holding the syringe around the protective sleeve, using an aseptic technique, pinch the skin of the patient's anterior abdominal wall below the navel line. With the bevel of the needle facing up, insert the needle at a 30 to 45 degree angle to the skin in one continuous deliberate motion until the protective sleeve touches the patient's skin. NOTE: The ZOLADEX syringe cannot be used for aspiration. If the hypodermic needle penetrates a large vessel, blood will be seen instantly in the syringe chamber. If a vessel is penetrated, withdraw the needle and inject with a new syringe elsewhere.

5.Do not penetrate into muscle or peritoneum.

6.To administer the ZOLADEX implant and to activate the protective sleeve, grasp the barrel at the finger grip and depress the plunger until you cannot depress it any further. If the plunger is not depressed fully the protective sleeve will NOT activate. When the protective sleeve ‘clicks', the protective sleeve will automatically begin to slide to cover the needle. NOTE: The needle does not retract.

7.Withdraw the needle and allow protective sleeve to slide and cover needle. Dispose of the syringe in an approved sharps collector. NOTE: In the unlikely event of the need to surgically remove ZOLADEX, it may be localized by ultrasound.

SIDE EFFECTS

General

Rarely, hypersensitivity reactions (including urticaria and anaphylaxis) have been reported in patients receiving ZOLADEX.

As with other endocrine therapies, hypercalcemia (increased calcium) has rarely been reported in cancer patients with bone metastases following initiation of treatment with ZOLADEX or other LHRH agonists.

ZOLADEX has been found to be generally well tolerated in clinical trials. Adverse reactions reported in these trials were rarely severe enough to result in the patients' withdrawal from ZOLADEX treatment. As seen with other hormonal therapies, the most commonly observed adverse events during ZOLADEX therapy were due to the expected physiological effects from decreased testosterone levels. These included hot flashes, sexual dysfunction and decreased erections.

Initially, ZOLADEX, like other LHRH agonists, causes transient increases in serum levels of testosterone. A small percentage of patients experienced a temporary worsening of signs and symptoms (see WARNINGS section), usually manifested by an increase in cancer-related pain which was managed symptomatically. Isolated cases of exacerbation of disease symptoms, either ureteral obstruction or spinal cord compression, occurred at similar rates in controlled clinical trials with both ZOLADEX and orchiectomy. The relationship of these events to therapy is uncertain.

There have been post-marketing reports of osteoporosis, decreased bone mineral density and bony fracture in men treated with ZOLADEX for prostate cancer.

Changes in blood pressure, manifest as hypotension or hypertension, have been occasionally observed in patients administered ZOLADEX. The changes are usually transient, resolving either during continued therapy or after cessation of therapy with ZOLADEX. Rarely, such changes have been sufficient to require medical intervention including withdrawal of treatment from ZOLADEX.

Prostatic Carcinoma

Two controlled clinical trials using ZOLADEX 10.8 mg versus ZOLADEX 3.6 mg were conducted. During a comparative phase, patients were randomized to receive either a single 10.8 mg implant or three consecutive 3.6 mg implants every 4 weeks over weeks 0-12. During this phase, the only adverse event reported in greater than 5% of patients was hot flashes, with an incidence of 47% in the ZOLADEX 10.8 mg group and 48% in the ZOLADEX 3.6 mg group.

WHOLE BODY - Abdominal pain, Back pain, Flu syndrome, Headache, Sepsis, Aggravation reaction

CARDIOVASCULAR - Angina pectoris, Cerebral ischemia, Cerebrovascular accident, Heart failure, Pulmonary embolus, Varicose veins

DIGESTIVE - Diarrhea, Hematemesis

ENDOCRINE - Diabetes mellitus

HEMATOLOGIC - Anemia

METABOLIC - Peripheral edema

NERVOUS SYSTEM - Dizziness, Paresthesia, Urinary retention

RESPIRATORY - Cough increased, Dyspnea, Pneumonia SKIN - Herpes simplex, Pruritus

UROGENITAL - Bladder neoplasm, Breast pain, Hematuria, Impotence, Urinary frequency, Urinary incontinence, Urinary tract disorder, Urinary tract infection, Urination impaired.

The following adverse events not already listed above were reported in patients receiving ZOLADEX 3.6 mg in other clinical trials. Inclusion does not necessarily represent a causal relationship to ZOLADEX 10.8 mg.

WHOLE BODY - Allergic reaction, Chills, Fever, Infection, Injection site reaction, Lethargy, Malaise

CARDIOVASCULAR - Arrhythmia, Chest pain, Hemorrhage, Hypertension, Migraine, Myocardial infarction, Palpitations, Peripheral vascular disorder, Tachycardia

DIGESTIVE - Anorexia, Constipation, Dry mouth, Dyspepsia, Flatulence, Increased appetite, Nausea, Ulcer, Vomiting

HEMATOLOGIC - Ecchymosis

METABOLIC - Edema, Gout, Hyperglycemia, Weight increase

MUSCULOSKELETAL - Arthralgia, Hypertonia, Joint disorder, Leg cramps, Myalgia, Osteoporosis

NERVOUS SYSTEM - Anxiety, Depression, Emotional lability, Headache, Insomnia, Nervousness, Somnolence, Thinking abnormal

RESPIRATORY - Bronchitis, Chronic obstructive pulmonary disease, Epistaxis, Rhinitis, Sinusitis, Upper respiratory infection, Voice alterations

SKIN - Acne, Alopecia, Dry skin, Hair disorders, Rash, Seborrhea, Skin discoloration, Sweating

SPECIAL SENSES - Amblyopia, Dry eyes

UROGENITAL - Breast tenderness, Decreased erections, Renal insufficiency, Sexual dysfunction, Urinary obstruction

WARNINGS

Initially, ZOLADEX, like other LHRH agonists, causes transient increases in serum levels of testosterone. Transient worsening of symptoms, or the occurrence of additional signs and symptoms of prostatic cancer, may occasionally develop during the first few weeks of ZOLADEX treatment. A small number of patients may experience a temporary increase in bone pain, which can be managed symptomatically. As with other LHRH agonists, isolated cases of ureteral obstruction and spinal cord compression have been observed. If spinal cord compression or renal impairment develops, standard treatment of these complications should be instituted, and in extreme cases an immediate orchiectomy considered.

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So as far as I read, hope you are getting the right treatment cause this seems to a bit dangerous to me...

God Bless U 2
Jean Op den Kamp (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by Jean Op den Kamp (imported) »

kizahakan (imported) wrote: Thu Jun 04, 2009 4:45 am So as far as I read, hope you are getting the right treatment cause this seems to a bit dangerous to me...

God Bless U 2

Thanks my friend, this I call a posting. ( Shortened it a little to save monitor ink, every one can read the original)

I agree, it might by a bit dangerous, but I accepted it................

the funny thing with those side effects is that they always forget to mention that if a train hits you when using it.......you die

loveUall

and Gods blessings 2U kizahakan

Jean
ramses (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by ramses (imported) »

Good luck with it all, Jean. As far as the warnings go, most would apply to aspirin, tylenol or anything else. They have to cover their ass for some of these "1 in 10,000,000" kind of scenarios. Androcur has a bad rap for liver and kidney damage but you rarley hear that it is in men in their 70s and 80s that are taking 800 mg/day or more.

Hopefully you get the relief that you desire without bad side effects. It sounds like you are doing what you know you need to do and I can respect that.
JesusA (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by JesusA (imported) »

I hope that this works well for you. Zoladex is one of a number of LHRH agonists that are widely used to treat advanced prostate cancer. Zoladex and Lupron are probably the most commonly used ones and there are thousands of men who are currently using it. Your doctor should be well aware of any potential side effects and know what both you and he should be watching for. Some men use one of these drugs for as long as seven or eight years as part of their treatment.

With long-term use, osteoporosis is the most serious side effect that you need to be concerned with. It is also the most important side effect that you will have with surgical castration. You doctor should already be looking for it and possibly treating it.

LHRH agonists are also used for other medical problems, such as delaying precocious puberty. They are also beginning to be used (especially in the Netherlands) for transgender children to delay puberty until they have had the necessary psychiatric evaluation to move on to surgical transition.

Another major side effect has to do with the wallet. All of the LHRH agonists are all very expensive, though your implant in the Netherlands seems to have cost far less than it would in the United States.
Jean Op den Kamp (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by Jean Op den Kamp (imported) »

Thanks Ramses

Thanks Jesus

To be honest: I am a lucky devil, the costs are for the insurance, no problems with my wallet.

Whaa, the United states are even more expensive.......

I like to compare the Netherlands with Vietnam: Calcium with vitamine D do have to same price.....one tablet at NL costs the same as a 100 box in Vietnam

Update: It is now little over 8 hours ago, and the burning pain is fading away.

I only will remember to ask next time if it can be placed lower...a few centimeters under the navel is just the line of the belt

loveUall

Jean

ps and for the first time in months, this moment I feel tired, really tired.

I'm going to make you all happy and jump in to my bed Goodnight
Jean Op den Kamp (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by Jean Op den Kamp (imported) »

Update:

It is 2.15am my time. 2.45am I will leave for my work. Didn't need the alarm, like normal. But I woke up by a halfway erection.

My room is 26 Celsius, and I feel completely cold, using my pullover, in an attempt to get warm. The burning pain from yesterday has gone completely, but this awful cold tells me enough. I am scared.

loveUall

Jean
DavidB (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by DavidB (imported) »

ramses (imported) wrote: Thu Jun 04, 2009 5:31 am Good luck with it all, Jean. As far as the warnings go, most would apply to aspirin, tylenol or anything else. They have to cover their ass for some of these "1 in 10,000,000" kind of scenarios. Androcur has a bad rap for liver and kidney damage but you rarley hear that it is in men in their 70s and 80s that are taking 800 mg/day or more.

Hopefully you get the relief that you desire without bad side effects. It sounds like you are doing what you know you need to do and I can respect that.

Ramses:

I heard about liver issues with androcur, but never heard about kidney issues, do you know what they are.

Dave
Jean Op den Kamp (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by Jean Op den Kamp (imported) »

DavidB (imported) wrote: Thu Jun 04, 2009 6:43 pm Ramses:

I heard about liver issues with androcur, but never heard about kidney issues, do you know what they are.

Dave

Yeah, and before I got the problems, I had never heard of Lichen Sclerosus.

But those problems with my foreskin did start at the same time I started androcur. I have no big problems with the circumcision, but it was sure not what I was asking for. The urologist told me that my condition was near a point of danger to develop cancer at the glans....not my goal. I got scared as I had to find out that my foreskin started to grow together with the glans

loveUall

Jean
Jean Op den Kamp (imported)
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Re: LH-RH Zoladex LA 10.8mg Implant

Post by Jean Op den Kamp (imported) »

Update: June 05

First of all: feeling completely cold, even if it is 35 or 40 centigrade, biting into your skin an going in to the marrow of the bones........

that is my hell. I knew what was coming, that was why I said: "I am scared"

Yesterday afternoon I went swimming for four hours. As I wanted to try my condition (not that well) I did the 20 meter basin under water and made a turn. I just wanted to see how far I could go on the return. I knew who was back at the moment I made that turn. For that POS, there is no maybe, there are only two options, make it all the way or die.

Yeah, I made it, and he just didn't care about the bouncing headache it gave me.

As I went home at 19.00, Ph**** (James my Vietnamese butler, long year friend, and father of P**) called me. He knew about my injection, he knew what I was afraid of, and he is one of the few people who really understand what it means what he calls: "You to hot". Ph**** not only knows, he has seen it a few times. He had been waiting until 19.00 (he knew about the closing time of the swimming pool) to call me and ask me how I was doing.

This means that at his country he had been waiting until after midnight.

This morning as I woke up, I knew it. I knew who was back, and this was just what scared me of so much. An all negative feeling, hating my situation, blaming each and every-one for what happened to me, wanting revenge.At the same time, everything did hurt me.....

I had to fight my way to every next address with a newspaper. I wanted to kick them all out. My legs like lead, completely tired. I could have destroyed in only an hour what I reached in several years.

At the depot (5.00am) the other paperboys and girls recognized that I was far down, and they asked what was going on. I told them that I had changed to another medicine, and that I could expect these problems for maybe a week. I got some strange looks, but they didn't ask more. I got respect and all the help they could offer. At 6.00am every-one was out with his or her newspapers. I started my country route, but I had it completely.

I remembered Ph**** calling me, those people helping me, I realized how many times in the last months I found back to my powers after nice postings at this board,..........

and most of all, I remembered who this asshole was, and that in fact, I didn't want to see him nor be him anymore. I didn't accept him anymore. That fight toke less then an hour. As I finished my newspapers and came home, I had my powers back, and little later, I went swimming again.

I didn't just win a battle today, I guess I finished a war

The place of the injection is just a little blue spot, and the implant I can't feel nor find. The zoladex doesn't do its work jet, so I will need to be patient a little more. I don't know what is coming the next days, but about one thing I am sure: That piece of shit is not going to take over again, not now and never in the future.

loveUall

Jean
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