Chemoablation

[racona78 (imported)]

Chemical castration with intratesticular injection of 20% hypertonic saline: A minimally invasive method (http://www.urologiconcology.org/article ... 8/abstract)

Abstract

Objectives

Our aim was to ablate testicular tissue by hypertonic saline solution in a rat model, thereby to discover a minimally invasive alternative method to medical and surgical castration in patients with metastatic prostate carcinoma.

Methods

A total of 40 male Wistar rats were divided into orchiectomy (n = 20) and experimental groups. In the experimental group, 20% (n = 20) hypertonic saline solution was injected into the rat testes. Blood was taken prior to, 1 day, and 30 days after the intervention for testosterone determination. All testicles were surgically removed for pathologic examination.

Results

Skin infection, necrosis, and testicular abscess were not detected in any rat. Pathologic examination revealed necrosis in almost all areas of the testicle. The comparison of 0, day 1, and day 30 measurements of total testosterone did not reveal a statistically significant difference between the control and hypertonic saline groups at each of the three time points (Mann-Whitney U-test, P > 0.05).

Conclusions

Intratesticular hypertonic saline injection seems to be an alternative method in the future to its rivals such as orchiectomy and medical castration. This new approach offers a minimally invasive and less expensive method aside from preserving body image in metastatic prostatic carcinoma. However, our conclusions should be supported with more experimental studies before a clinical study is taken into account.

[racona78 (imported)]

Any thoughts? Saline has to be a lot safer then lactic acid or other more harsh things like alcohol. Although 20% hypertonic is a bit salty.. lol.

[malenomore (imported)]

This is very interesting, hope there is more information to come and discussions from all the knowledgeable folks out there.

[chilliwilli (imported)]

Any thoughts? Saline has to be a lot safer then lactic acid or other more harsh things like alcohol. Although 20% hypertonic is a bit salty.. lol.

You could call a eunuch an "OLD SALT" then, how wonderful!

It sure beats the life of a an 1800 mariner. And a stickin' rotten crotch is better than a worm riddled, rat infested mons o' war, or even worse putrid back breaking duty on a whaler searching for micky dick.

Where's the love?

The disgruntled domestic

chilli-

[Paolo]

Let's not go into the testicular injection subject again.

NOT something that we recommend.

[DeaconBlues (imported)]

Let's not go into the testicular injection subject again.

NOT something that we recommend.

OK, so I won't go into this subject... but now my curiosity has got me. WHY is it something you do not recommend? On the surface, it appears to be an easy and economical alternative to the outrageously priced surgical option, and it sure seems better than the burdizzo or any do-it-yourself surgery... What is wrong with this saline injection method?

[JesusA (imported)]

WHY is it something you do not recommend? On the surface, it appears to be an easy and economical alternative to the outrageously priced surgical option, and it sure seems better than the burdizzo or any do-it-yourself surgery... What is wrong with this saline injection method?

Two key problems:

(1) There have been disasters with both alcohol and Chemcast injections, and

(2) This has been done (so far) only on 20 juvenile laboratory rats.

Before anyone runs off and tries it, we need FAR better information. We don't need another disaster. I will try to run down as much information as I can and let you know....

[nullorchis (imported)]

Although I have personal experience with being needled in the orchis, I would never consider injecting any fluid directly into them, or into my brain or heart for that matter.

I do have a personal fascination and interest in medical suction needles. They are part of an expensive system used in operating rooms for delicate operations where small suction devices are needed to remove blood clots, tumors, and other nasty things. I fantisized that such a needle might be used to vacuum out the contents of a testicle leaving it something like a deflated balloon.

Undoubtedly this will remain a fantasy, not a reality. Too bad; it seems like it might have potential.

[DocT (imported)]

Please don't anyone try this. We've heard a lot of horrer stories on this site.

One quick thought: The primary vein of the left testicle joins the main vein of the left kidney. Saline destroys veins. As the saline dumps into the kidney vein it could compromise it. Will this lead to higher blood pressure in the kidney? It seems reasonable. If it did, progressive kidney disease would be a likely result.

DocT

[racona78 (imported)]

Sure hypertonic saline destroys tissue (dehydrates the cells). In a vein I doubt it would do MUCH damage to the actual vein since it would be moving through it fairly fast and getting diluted, it would however kill any blood cells in the hypertonic solution and then when it hit the heart and lungs might not be so good.

But in the venious return your not going to damage your kidney like your thinking, since its not going to go near them.

There of course is risk with injecting chemoablative chemicals into your body, and hitting into a vein or artery would be one or targeting undesired tissue.

Let's not be giving out advice on how to do this. Thanks. -P.

The other issue is aquireing sterile 20% hypertonic saline... its not eactly easy to come by.

The testicle is a pretty large thing to be injecting with a small needle, some care probably would be needed to not hit veins, but I don't think it would be really that hard to get the needed somewhat center.

As for the other injections on the site and horror stories. Saline is a natural chemical found in the body, although isotonic is 0.9%, so 20% is pretty concentrated, it would just dilute down to isotonic as it goes though the body, and if you don't inject TONS (I wouldn't consider abve 1ml, probably 1/2 mil would be enough) you're probably not going to destroy alot of tissue.

Hypertonic saline from what I've seen is a pretty well reasearched solution for chemoeblation in many different organs. It dosn't hold much promiss for killing cancer though due to it's unpredictable destruction path through an organ since it difuses through it. But for our purpose we're not trying any precision beond killing an entire, small, organ. Which so long as you stick with SMALL amounts of injectable it shouldn't be hard. Killing not enough is better then your whole penis falling off.

Going to a doctor and paying several grand isn't even remotely possible for some people...