bph and prostate cancer

[helen (imported)]

Hi, I truly wonder why you say this. This book which has more footnotes than any I have read since college! seems pretty well researched. I think his health benefit enumerations seem OK. What is your complaint with what Mr Cheney writes? thanks, helen

[sduyck_2000 (imported)]

a article i found online of a recent study

Epidemiological studies strongly support the contention that surgical castration prior to age forty prevents both benign prostatic hypertrophy (BHP) and prostate cancer. 5-Reductase deficiency in humans, an experiment of nature, is an uncommon genetically transmitted disorder in which prostate size remains very small throughout adult life. A 5-reductase inhibitor, finasteride, has recently been shown in double-blind, placebo-controlled trails in patients with BPH to statistically decrease prostate size and improve clinical symptoms in comparison to placebo controls. In the untreated BPH prostate, tissue levels of dihydrotestosterone (DHT) and testosterone (T) averaged 4.2 and 0.2 ng/g, respectively. Following one week of finasteride therapy, T levels rose to a mean of 1.32 ng/g while DHT levels decreased to 0.62 ng/g. These values contrast with values in prostate tissue form surgical castrates in which DHT and T values average 1.14 ng/g and 0.1 ng/g, respectively. If we use the relative binding affinity of T and DHT to the androgen receptor as a criterion of biological androgen potency, T would appear to be one-fourth as potent as DHT. Using this 1:4 ratio to convert prostatic T to a biologically equivalent amount of prostatic DHT, the total biologically active DHT equivalent in the prostate following one week of finasteride averages 0.95 ng/g compared to a mean of 1.14 ng/g in surgical castrates. If the acute effects of finasteride on tissue T and DHT persist during chronic therapy, prostatic hormone concentrations could be said to closely resemble those found following surgical castration; such changes might prevent the occurrence of prostate cancer, similar to the effects noted after surgical castration in younger males. © 1992 Wiley-Liss, Inc

[kristoff]

a article i found online of a recent study

Please send us a link to the source. Would be much appreciated.

[sduyck_2000 (imported)]

here is the link

http://www3.interscience.wiley.com/cgi- ... 1&SRETRY=0

[mrt (imported)]

Please add my strong agreement with Prof W's statements. I feel plenty human and the experience was fine other then normal post op soreness etc.

I have to admit to surprise that your prostate has shrunk if you've been on HRT for 15 years? This is (I think) some very important information that our medical community should know about. I always thought hormones be they Androgel or the kind the testicles make did pretty much the same thing. What action changes if you maintain Testosterone post op? Very very interesting because I also have some family members who died from prostate issues. Do you try to use minimal amounts of HRT or are you on a normal male level?

Thanks for starting this thread!

[sduyck_2000 (imported)]

I read at the adrogel website that applying it on the shoulder allows it to be absorbed as testosterone as it bypasses the receptors in the scrotum which convert it to dht.

Dht causes the prostate to grow and hair on the head to fall out.

My blood test showed I had 4.4ng/ml testosterone in my blood

that is mid range....considering it had been 24 hours since last application ..it has good staying power.

[plix (imported)]

DHT is not all evil. In fact, we all need it, and some of us need it more than others.

DHT is a much more potent form of regular T, and it exhibits the effects of T in ways stronger than ordinary T can.

I am one of those people who really needs it in order to get the full effects of T. This is strongly suspected because for me the gel works better than the shots, contrary to what most people find. The gel converts to DHT at a much higher rate over the shots because the skin is an excellent source for T to DHT conversion. So transdermal methods of T replacement cause a higher DHT level. Since I do better with these methods, it is likely that I need more DHT than others do.

Also, DHT will not cause MPB (male-pattern baldness) if there is no genetic susceptibility to it.

[mrt (imported)]

Marcy Bowers in Colorado is a transgender woman who is an MD who does transgender surgery. Orchiectomy as a prelude to transgender surgery is not uncommon. I would suggest you contact her.

Contact info someone?

http://marcibowers.com/

I've spoken to her. I also met her Web Mistress (A SRS Patient - a very neat lady) & I like this doc. I was "this" close to having her do my op. Anyway I'm very glad she was available as plan B. I also spoke to Dr Alter (Hairless suggested this) and I found him to also be a very charming guy and very in the know.

Speaking of which I think the main issue for all surgeons is that they not want to do any surgery on people who are incapable (mentally) of understanding what they are asking for. I know there is some debate on the current standards of care but I think the idea in general has merit. And as a guy who was asked to be "checked out" prior to my own surgery? Looking back I see it as two things. Affirmation to the surgeon that he/she was not operating on a "Heavens Gate Mark II nutjob" and a chance for the patient to go over the whole thing with a 3rd party. *And while I was a bit angry at what I thought was having my sanity "questioned" I found the experience to be positive. *And in any event it didn't take long to do.