Danya (imported) wrote: Thu Jan 24, 2008 6:16 pm I appreciate the information on Spironolactone, plix. I knew this would be a possible choice but I didn't know that it was that ineffective, when used alone, in reducing testosterone to castrate levels.
Knowing this, I will suggest to the endocrinologist that I stay on Androcur and continue to be monitored for side effects. This could result in a heated discussion.
When I was reducing my daily dose of Androcur, by half, to conserve the drug until more arrived, I noticed no difference in my feelings the first five days. I was pleased because, on one pill a day versus two, I would save a lot of money. After that initial period, though, I started to feel out of sorts. When I further cut the dose by 3/4, I felt even worse.
This certainly isn't conclusive proof of anything. I suspect, though, that I was experiencing a rise in testosterone. Certainly not to pre-Androcur levels by any means, but enough to leave me feeling unhappy.
Keep in mind the manufacturer of Androcur does not recommend prolonged use of high doses because of prospective hepatic damage. They generally recommend a relatively (not massive) high dose to attain effect, and then progressively reduced dose until effect is maintained at a reduced dose.
At first, that bothered me a bit. Now, I see how easy it is for that to happen and even how I've facilitated the 'wandering' at times.