Androcur Effects

[hkeunuch (imported)]

Hi All, I have been on Androcur for exactly 3 months now. The effects are rather confusing and would like others who have or are using Androcur to give me any advice or comments.

I have started with 100 mg/day for about 1 week, ramping up to 150 mg/day for another 10 days, then ramped back down to a sustaining level of 50 mg/day.

Sexual Functioning -- no nocturnal erections at all. But I still get spontaneous erections when I see stimulating movies. As before, I sometimes have trouble getting sufficiently hard to penetrate. But I also enjoy being passive anyways. But casual hand stimulation can take much longer to get any reaction.

Climax -- I can still achieve climax, but besides a little clear precum, ejeculate has completely dried up. But the feeling of climax remained pretty much the same as before.

Libido -- My libido seemed to be lessened, but I would still get the wish to have sex with guys about once a week.

Other Supplements -- I have been taking a stress formula Vitamin B complex with zine, and calcium.

Other Medications -- I am on medications for hypertension (but not spirolactone) and cholesterol.

Health Conditions -- Generally fine. But about a month before starting Androcur, I found I have a mild case of aneamia. I just had a complete health check up recently, my liver, kidney functions are normal. And the mild case of aneamia remained. The doctor started me on iron supplements.

There was not much weight change. I think I lost a bit of muscle mass and gained a bit more fat tissues. But that could be my general lack of exercise.

Mood -- Generally calmer.

Questions: I seemed to be getting some effects of Androcur -- the dry ejeculations and calmer moods. But what troubled me is the generally unchanged sexual needs and spontaneous erections. Am I taking too low a dose? But I fear a higher dose might affect my health conditions. Any advice or comments would be welcomed.

[allen stretch (imported)]

Hi hkeunuch. I have been on androcur for four months now. Like you i started on 100mg a day for a week, but then dropped back to 50mg. Have maintained the 50mg a day until last week when i dropped down to 25mg a day as i was not sleeping so good, and my skin was getting dry and itchy. this seems to have sorted things out, and i am hoping the dose is not too low to maintain my castration.

As to your question. Like me, the fact that when you masterbate to a climax there is no or a very little clear ejaculation, this to me a clear indication that you are at castration levels.

I do do get the occasional semi erections when things are right, but have to work quite hard, and concentrate to come otherwise it goes soft and i give up. My most enjoyable times are when my wife holds my limp penis and atrophied balls, which soon becomes semi erect for a few moments and then just as quickly goes back to being completely soft, this is when i am at peace with the world. She will hold it for long periods,quite often till i fall asleep.

As for the occasional semi erections, from what i have read even eunuchs that have been surgically castrated still get them. So i am afraid it looks likes its one of life's annoyances that we will have to learn to live with

unfortunately

Hope this clear things up a little

[hkeunuch (imported)]

Hi Allen, Thanks for sharing your experience with me. It's good to know that I am not the only one still getting the annoyances. Unlike you, I do get rock hard erections without any helping hand just by watching the right movie. I enjoy the feeling of masterbation. But most of the time, there is really no urge to cum at all, even though the dry climaxes do feel good. I guess everybody's mileage is different. But with your experience as reference, I can feel more assured about my current dosage. Thanks.

[kellyts (imported)]

I have been cyproterone now for 6 weeks so I'll hold some comments, but I think there are some common mis-conceptions concerning androcur/cyproteron.

At first I just looked at the andi-androgen data comparing and contrasting etc. Then the post on LHRH Angonist came out and I was surprised what I found.

Androcur in and of itself even at doses of 200-300 mg/day will not get you to castrate levels just close. According to a study I read, and I can not find it again, on prostate Cancer treatments adding Estrogen with androcur is the only way to get to near castrate levels.

According to that same study and I have not seen anyone here state otherwise, at least that I recall, you do not get hot flashes on androcur.

There is not a great deal of test data on androcur as compared to say US manufactured LHRH antongist. What is clear is almost all the data suggest somewhere around 100 mg/day is nominal and at about 200 mg/day is when it effects the T generated in the pitilitary gland.

I found all this quite interesting and because I take estrogen also I'm Ok with the info. Each person is different and the same doseage in two people can not be compared.

K

[Alfred (imported)]

when it effects the T generated in the pitilitary gland.

Question 1: what is “pitilitary”?

Question 2: if by “pitilitary” you meant pituitary how come does it generate T? Hope you meant [yet again] LH, not T

There is not a great deal of test data on androcur

Unfortunately this is the case

Have a look:

Medium dose cyproterone acetate (CPA; 10 mg daily p.o.) was administered to 10 fertile men for 12 weeks. Hormonal measurements and semen analyses were performed before, during (4th and 12th week) and after CPA treatment. At the hypothalamo-pituitary level CPA significantly reduced the hypophyseal storage and synthesis capacity for gonadotropins. Basal LH and FSH concentrations were suppressed by 30% and 40%, respectively; while basal prolactin was elevated by 75%. The episodic fluctuations of peripheral gonadotropins remained unaffected. At the testicular level CPA significantly decreased basal testosterone and dihydrotestosterone concentrations by 70% and 50%, respectively. The pulsatile pattern of androgen secretion was abolished. CPA also inhibited spermatogenesis and motility. No serious clinical side effects were observed. All changes appeared to be completely reversible. It is concluded that medium dose CPA induces progestational/anti-gonadotropic effects at the hypothalamo-pituitary level in addition to its antiandrogenic action at the testicular level.

Ref: http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

There are, however, two problems with this study: small sample size and the fact that it’s 26 years old. At the time (1980) computers were non-existent as such, so the accuracy and statistical significance of the measurements performed as part of this study is questionable.

Androcur in and of itself even at doses of 200-300 mg/day will not get you to castrate levels just close.

You do realise that the “castrate levels” aren’t exactly T and DHT at 0 ng/mL(nmol/L)? That is, the castrate levels aren’t TAB.

[Malecheii (imported)]

I have read all the drug company literature and agree that 200 mg+ is necessary to mostly eliminate T production. 100 and less is recommended to curb "deviant" sexual behavior. So, depending on your goal, you can scale the dose to fit what is right for you.

I also see that inhousepharmacy now has generic Androcur which is much more affordable..

Malecheii

[kellyts (imported)]

Wanted to correct the following paragraph and add a couple of minor things.

There is not a great deal of hard core

test data on androcur as compared to say US manufactured LHRH antongist. What is clear is almost all the data suggest somewhere around 100 mg/day is nominal and at about 200 mg/day is when it effects the T generated in the

adrenal gland.

Androcur doseage of 100mg/day is recommended for those with prostrate cancer and having had an orchi. And is given in concert with LHRH Antagonist to reduce physical effects of orchi: hot flases in particular.

Most of the data I've seen states that androcur will reduce serum T levels by 70-95%. Castrate T levels are normally defined as less than 50 ng. Female range runs from 18-80 ng. If one had a serum T level of 450 ng then 82.5% reduction (mid range) would still leave 79 ng.

I have been on CPA now for seven weeks, 150 MG/day plus 8 mg estrogen. After 4 weeks my T level was down from 421 to 120. The doctor wanted to wait until week eight to test again and decide which way to go in doseage.

Many of the same complaints, lack of energy, almost impossible to even get semi erect. Seminal fluid clear and sparse. Some muscle weakness, but I try to counter that with exercise. Have lost 8 lbs in last 7 weeks without dieting. Seems CPA/androcur inhibits carb processing so it is like you are on the low carb diet without all the work.

K

[hkeunuch (imported)]

Hi All, My Androcur treatment is getting to 6 months. While nighttime and spontaneous erections are basically gone, my libido has hardly diminished.

Though just masterbating by hand would not get it very hard, the right movie or sex partner can get it fully hard.

The sexual desire just changed from being versatile to becoming a passive gay sex. But the desire to get passionate with guys remain strong. My interest in sex just moved from a desire to cum (which does become very infrequent -- once or twice a month, down from a few times a week) to a desire to having receptive sex orally or anally. And this strong desire is really bothering me.

I have been sustaining at 50 mg per day for the past several months, and in the last week, decided to go for a short period at 200 mg. So far, I cannot say I sense much improvement.

Has anybody been on Androcur longer than 6 months but still retain much of his libido? If the manufacturer's instructions say that to reduce sexual behaviors, 100 mg or even 50 mg would be adequate, I wonder what I am missing.

Can anybody please give me some advice or share your own experience?

[hkeunuch (imported)]

Two weeks ago, I have increased my Androcur dosage to 200mg/day.

I just had a health exam and everything, including liver function, remains normal. My testosterone level is at 1.37 ng/mL. Although it is well below the levels of a normal male (2.80-8.00), I am still not quite at the castration level (<0.50 ng) as kellyts mentioned below.

I think I am feeling more the effects of castration -- feeling a bit less interest in sex, but still not completely eliminated.

I suppose I will stay at the current dosage for another 2 weeks before consider reducing the dosage.

[kellyts (imported)]

Two weeks ago, I have increased my Androcur dosage to 200mg/day.

I just had a health exam and everything, including liver function, remains normal. My testosterone level is at 1.37 ng/mL. Although it is well below the levels of a normal male (2.80-8.00), I am still not quite at the castration level (<0.50 ng) as kellyts mentioned below.

I think I am feeling more the effects of castration -- feeling a bit less interest in sex, but still not completely eliminated.

I suppose I will stay at the current dosage for another 2 weeks before consider reducing the dosage.

hkeunuch,

Just a question, the 2.8-8.0 number you mentioned sounds like the % of free testoserone vs. the serum T level. The %T is the unbound T running through your body. For chemical castration the lower the number the better. Male range is .3-8. Of course each lab that does blood work has a reference they use which WILL vary the range.

Kelly