LHRH-agonists

[vesal_mas (imported)]

A lot has been written about androcur and depoprovera. Allthough there is also another way to achieve chemical castration.

Normally the hypothalamus stimulates the hypofysis to release the luteinizing hormone wich, in turn, stimulates the testes to produce testosterone with the masculin features following. Therefore the hypothalalus produces a hormone called 'luteinizing hormone release hormone'

One can take a synthetic analogue of this hormone wich consequently raises the testostorone, but after some 10 days the human body stops producing LHRH, so stops producing LH and so stops the production of testosterone, which is our goal.

I just wondered why I saw nobody tempting chemical castration this way.

Greetings to all !

Vesal.

[Alfred (imported)]

Well, after having to reregister for the third time, I can post again

Vesal, apparently you are talking about the hormone, which is better known as GnRh (Gonadotropin-Releasing hormone), right? To answer your question (

why I saw nobody tempting chemical castration this way.

):

A.) Very few know about GnRh-a’s (Gonadotropin-releasing hormone agonists);

B.) Those drugs(Goserelin acetate, Leuprolide acetate, Nafarelin acetate - are the one’s I know of) are expensive and very difficult(if not impossible) to get unless one has a prescription;

C.) Their safety record, especially for Leuprolide acetate, is far from perfect;

D.) Why use GnRh-a, when one can use CPA(cyproterone acetate) to reach the same effect and CPA is easily available, much cheaper and safer(yeah, I know, saying that CPA is safer than something else is a bit uncommon, but in these circumstances it’s probably appropriate)

[plix (imported)]

I have mainly heard about the cost factor being the obstacle, but I imagine there may be other reasons as well like the ones Alfred suggested.

[meramums (imported)]

I have got a injection of Decapeptyl, which active substance is triptorelin.

My doctor is a sexolog, as we call it in Sweden.

I have previously used CPA, which lowered my testoserone only to half, and kept most of my drive and abilitys functioning.

With triptorelin my testoserone will go down to a value of 1 from 13, and now 3 weeks after the injection I think I'm almost there.

My interest in sex are quite lower, but I still can get erections and make love with my wife, although it feels much less from a physical point a view.

Psychological it feels better, and I feel more intimate, and more loving.

So LHRH antagonists are more effective, actually, it is the only drug that can give a total androgen blockade when combined with an antiandrogen such as Flutamide.

I'm not a pedophile, although I have other annoying paraphilias, but I have read reports on drug treatments on pedophiles, and apparantly triptorelin works much better than cyproterone acetate.

[happousai (imported)]

Is this anything similar to GnRH agonists? I vaguely recall hearing that they are prescribed to young M2F transsexuals in order to prevent them from masculinizing at puberty. (I wonder why they use GnRH agonists instead of androcur/spironolactone.)