Cimetidine for Shrinking Penis and Lowering Libido

[sftineun (imported)]

Update: a liver test came back slightly off while I was taking Cimetidine (usually 800mg, sometimes 1000) for ulcer symptoms. My T was fine from the same round of tests (I'm on TRT). The stuff DID put my erectile function into a sort of roulette/lottery situation. Some days there was no erection to be had regardless of mood or stimulation, some days things were normal, and some days there was an urgency 2-3x per day I haven't felt since I was a teenager.

I stopped taking Cimetidine as soon as I got the call from the doctor's office, and my follow-up test was normal. I'm not an MD, but I suspect the almost-randomness of my functionality (and the wonky liver test) was my body trying to deal with both Androgel and Cimetidine simultaneously.

Thanks for sharing your experience. I guess I am not alone taking androgel and Cimetidine. And I too am experiencing the roller coaster ride of one day horny, another days totally sexless, some time the penis just won't wake up from its tiny state, and other days, jump to erection with the slightest touch, or just some sensual thoughts.

I have stopped Cimetidine for a few weeks now. But this roller coaster ride continues.

For the past few days, I would feel horny. I could not get any reaction from the penis. But after much work, I could bring myself to edging on orgasm, with a spongy soft penis.

I actually don't mind the softness. That has been my goal. I just don't like the horniness from the Androgel.

However, I don't want to develop my breast any more. I think the current size is just right, enough to be sensual, but small enough that I don't need bras or support.

Not sure what alternative route there is to maintain low libido and stop osteopenia, and minimal furthering of feminization.

[WheelyCurious]

However, I don't want to develop my breast any more. I think the current size is just right, enough to be sensual, but small enough that I don't need bras or support.

Not sure what alternative route there is to maintain low libido and stop osteopenia, and minimal furthering of feminization.

Look into / talk to your doctor about 'SERMs" - they are an estrogen replacement alternative that was originally developed for women w/ hormone sensitive breast cancer that still wanted / needed estrogen...

Tamoxifen is one of the first generation SERM's and there are at least two generations of more advanced ones.

SERM stands for Selective Estrogen Receptor Modulators, or something like that. Basically there are different sorts of estrogen receptors in different body systems, and these are selective in that only certain sorts of receptors respond to them, w/ breasts being one of the ones that don't, and bones being ones that do...

WheelyCurious

[sftineun (imported)]

Look into / talk to your doctor about 'SERMs" - they are an estrogen replacement alternative that was originally developed for women w/ hormone sensitive breast cancer that still wanted / needed estrogen...

Tamoxifen is one of the first generation SERM's and there are at least two generations of more advanced ones.

SERM stands for Selective Estrogen Receptor Modulators, or something like that. Basically there are different sorts of estrogen receptors in different body systems, and these are selective in that only certain sorts of receptors respond to them, w/ breasts being one of the ones that don't, and bones being ones that do...

WheelyCurious

Thanks for the info. I had used Tamoxifen before, during the 4 years I was getting myself chemically castrated, using a combination of Androcur and Tamoxifen. And I continued with Tamoxifen for another year or so after stopping Androcur to slow down breast growth. I had changed Raloxifene/Evista for a few years. But I guess all that did not prevent my starting osteopenia.

[WheelyCurious]

Thanks for the info. I had used Tamoxifen before, during the 4 years I was getting myself chemically castrated, using a combination of Androcur and Tamoxifen. And I continued with Tamoxifen for another year or so after stopping Androcur to slow down breast growth. I had changed Raloxifene/Evista for a few years. But I guess all that did not prevent my starting osteopenia.

I pointed at a paper I found from an endocrinology journal (so presumably reputable?) https://www.frontiersin.org/articles/10 ... 01364/full It has a table in it that lists the SERMs and estrogen, and what they effect.

Per 'Table 1' Tamoxifen is generation one, and had mild good benefits for both spine and skeletal bones.

Relaxifene is generation two, and is better for spine (but not as good as estrogen, but NOT as good for the skeletal bones...

Lasofoxifene is generation 3, and is supposed to be as good as estrogen for the spine, and good but not great for skeletal bones...

Downside of all the SERMs is that they have a greater risk of blood clots than estradiol....

I definitely recommend reading the entire article for yourself.

WheelyCurious

[Qunuch81 (imported)]

Cimetadine users--anybody taking additional prescription meds? Any interactions?

[Stevenator_too (imported)]

BP & HRT. The only reaction I got was a rapidly shrinking penis.

[Qunuch81 (imported)]

Cool. I'm on Lexapro, Trintellix (antidepressant), and Wellbutrin, as well as HRT. My queer nurse practitioner (who is, in fact, a doctor) said to go ahead and try the cimetadine, but to take it slow to start. Typical doctor advice, which I'll follow. If it turns out I can stay with it, I'll post updates.

[MalaKita (imported)]

Here's an update after consuming two bottles in this round. The result is quite confusing. In the lowered state, there was a decrease and now it is barely 5 cm (2 inches). But almost every erection measurement gives me a different result. One day it is 10.5 cm, and the next day it is 11 cm. Regardless of that difference, the result was absent this time.

In the last cycle, I lost 0.5 cm per bottle. And now there is no such result.

What is interesting is that the difference between the penis in a relaxed state and in an erect state is as much as 120%.

Otherwise, this difference before the reduction was about 60%.

Maybe the problem is that this time I am using cimetidine at the same time as the PM therapy. I still have two vials of cimetidine left and because of these results, I will use them only when I finish this therapy with PM, which will not be until the fall.

[Stevenator_too (imported)]

Cimetidine completely blocks DHT, (as well as attacking the Leydig Cells). Stopping DHT is required for breast growth, especially with PM. If you stop Cimetidine, you can substitute Red Reishi Mushroom in its place. No herbal supplement stops DHT for NBE better than RR.

[MalaKita (imported)]

I forgot to write that I take PM together with RR. And with them there is also cimetidine. Also, I forgot to write that my libido is almost at zero and that my penis barely achieves an erection. And when he gets an erection, he starts falling almost immediately.