Getting an urologist to remove my testicle?

[kazimirmanxie2044 (imported)]

Okay, what would it take to get a urologist to remove my testicle on the NHS? Obviously purposely damaging my testicle would be a way of doing this.

I have considered other castration methods like using an elastrator or an emasculatome, however they seem too painful? And my tolerance to pain is not very good lets say.

I have looked alcohol injections, however due to me living on the Isle of Man I cannot get higher proof alcohol than Smirnoff branded vodka which is about 37% and no higher.

I honestly don't know how to get hold of calcium chloride nor do I know how to get hold of a hypertonic saline solution, however I can get hold of a normal saline solution from a local pharmacy.

I heard that an intratesticular injection of normal saline solution can cause the testicle to swell up in size, so perhaps that could be used to fool an urologist into removing the testicle out of medical necessity?

My reasons for wanting to be fully castrated are because of my gender identity and because of post-operative pain from way back when I had to get an unilateral orchiectomy to remove a benign testicular tumor. I have one testicle and I seriously don't want it anymore, I seriously don't want to take blocker forever.

So, what alternative substances could I inject intratesticularly to cause the testicle to be damaged beyond repair?

What size and gauge needle is the best for injecting painlessly? I use 1/2 inch insulin needles for hrt at 32 gauge.

Thank you.

[cutoneuk (imported)]

Calcium Chloride is used in cheese making. As it is food grade it is relatively pure and not "industrial" grade which does not need to be so refined.

Make enquiries about cheese and track down a supply like that.

[Paolo]

While we don't recommend it, there are two long threads running on this forum about ethanol injection, as well as calcium chloride injection.

[CFI10000 (imported)]

Introduction

Zeuterin™ is a non-surgical sterilant for male dogs delivered via intratesticular injection. The active ingredient is zinc gluconate neutralized with arginine. The formulation causes permanent sterility in one treatment. The process of neutering with Zeuterin is also known as “zinc neutering.”

History

This formulation of the chemical compound of zinc gluconate neutralized with arginine was developed to chemically sterilize male dogs. The formulation was initially developed by Pet Healthcare International; it received approval from the United States Food & Drug Administration (FDA) in 2003 and was distributed in the U.S. under the name Neutersol® until early 2005. Ark Sciences, Inc., subsequently acquired rights to the technology and registered it under the name EsterilSol™ in Mexico, Colombia, Bolivia, Panama, and Turkey. On February 17, 2014, Ark Sciences launched Zeuterin™ in the U.S. It is presently approved for male dogs between three and 10 months of age in the U.S., and for male dogs over three months of age in the other countries. Ark Sciences is currently working to modify the label in the U.S. to include male dogs three months and older.

Mechanism of Action

The exact mechanism of action of Zeuterin is not known. The product is administered as an intratesticular injection into the center of the testicle via the dorsal cranial portion of testicle, parallel to the longitudinal axis. After injection, the compound diffuses in all directions from the center of the testis. In the concentration used, zinc gluconate acts as a spermicide and destroys spermatozoa in all stages of development and maturation. Zinc gluconate is absorbed and metabolized by the body within 72 hours after the injection. As the dog’s body increases blood flow and creates inflammation to heal, it results in permanent and irreversible fibrosis in the seminiferous tubules, rete testis, and epididymis. This process results in permanent sterilization, and the endocrine feedback system remains intact. Following injection, the testicles atrophy over a period of time ranging from weeks to months, resulting in a reduction in testicular size and changes in shape or texture. These changes may or may not be symmetrical.

Use and Effectiveness

Injection technique is critical to preventing adverse reactions. Because of this, Ark Sciences requires veterinarians to be certified in its administration. Zeuterin is administered via an injection to each testicle with either a 28 gauge, ¾-inch or a 30 gauge, ½-inch needle, depending on testicle size. Dosage is determined by measuring each testicle with a caliper provided by Ark Sciences. The correct dose is indicated on the caliper and is based on the maximum width of each testicle. Zeuterin is labeled for use in dogs with an individual testicular width of 10.0 to 27.0 mm, although the product has been used in dogs with testicular widths of up to 31.0 mm.

Anesthesia is not necessary for the zinc neutering procedure. Ark Sciences recommends light sedation to ensure that the dog holds still during the injection; reversible sedation is commonly used so that dogs are awake and alert in as little as 15-20 minutes after the injection.

Concerns about possible pain of an intratesticular injection are not uncommonly expressed by pet owners or by practitioners who are not experienced with this technology. In studies reviewed and accepted by the FDA (in which 76 percent of dogs were not sedated), only 2.5 percent of dogs showed discomfort by moving or vocalizing. The other 97.5 percent did not show any reaction to the injection. Scrotal pain was the most common local reaction observed in the FDA-reviewed study, reported in 6.3 percent of dogs. To prevent discomfort caused by post-injection swelling, Ark Sciences recommends concurrent use of a nonsteroidal anti-inflammatory drug (NSAID).

Testosterone, Behavior, and Health

One study submitted for FDA approval measured the effect of Zeuterin on male beagles (six months of age at the start of the study) in a clinical setting. At two years post-treatment, mean serum testosterone levels for dogs who received varying quantities of zinc gluconate neutralized with arginine were between 41.0 and 52.0 percent lower than mean serum testosterone levels of dogs in the control group.

The effect of maintaining higher levels of testosterone on hormone-dependent behaviors and diseases has not been established. Some people seek behavioral changes commonly associated with surgical castration, and thus view a lesser impact on testosterone production as a drawback. Other pet owners cite health and behavior benefits from retaining some level of circulating testosterone. Although more is known about the non-reproductive (behavior and health) effects of surgical castration than sterilization with Zeuterin, further study on both methods is merited.

Expected Reactions and Complications

Proper injection technique is critical to prevent adverse reactions. Normal reactions include:

• Generally non-painful swelling for 24 to 48 hours

• Listlessness for the first 24 hours

• May or may not vomit during the first 24 hours

• Should return to normalcy within 24 hours

According to Ark Sciences, only 1.1 percent of the 270 dogs in FDA Clinical Trial needed any follow-up medical attention. The most common complications, and their recommended treatment, include:

• Scrotal irritation: apply anti-inflammatory/antibiotic ointment, possible E-collar, 2 to 3 days

• Scrotal ulceration: antibiotics, saline soaks, E-collar, 1 to 2 weeks

• Testicle abscess/infection: antibiotics, E-collar, 1 to 2 weeks

• Scrotal ablation may be necessary in the event of severe ulceration

Conclusions

Zeuterin is a safe, effective method for sterilizing male dogs without surgery. Though sedation is recommended and administration protocol requires precision and care, this method may offer savings in cost, time, and facility requirements, thus helping animal welfare organizations sterilize more animals and/or redirect resources to other lifesaving projects. It also presents an option for pet owners who would prefer to sterilize their dog without surgery, or whose pets cannot safely undergo anesthesia.

References

[Cseriess (imported)]

Wasn't it taken off the market in 2016?

[CFI10000 (imported)]

You are correct. It does not say that it was taken off from being unsafe.

Notice: Zeuterin was commercially launched in the U.S. in 2014, following approval and use in several other countries by the name EsterilSol. The product, which was manufactured by Ark Sciences,

is not currently being produced or distributed in any country due to the manufacturer’s financial challenges.

While there is presently no indication of returning to the market, the formulation retains approval by the U.S.

Food & Drug Administration (FDA).

It's said to contain zinc gluconate and the amino acid arginine

[CFI10000 (imported)]

It would be interesting for you to check out this link. The question is, how old are you? Why do you want to do this?

Mine were removed because I wanted implants. TRT made them shrink, I am 55, I knew that mine were not working. I was already on TRT and it's working well for me.

I would have liked it better if I did not need to go on TRT (and if my testicles were were bigger). My choice was either to get a better dose of T with a drug or be low. My TRT is called Natesto and it's a nose gel. I like having nice size implants. At my age, my nuts were already shot (not working well).

TRT or other treatments are expensive. Doctor visits are expensive. You get depressed when your testosterone is low. Don't do this if you don't have to. If there is a good reason (like you are certain that you want to transition), that is different.

Share what you are feeling and people on here will give you some advice on how to find the right doctor.

I posted this because it has been tested. The ingredients are from a health food store. There is information on the dose. Calcium Chloride is essentially road salt.

It's most likely they took Zeuterin off the market because the company probably did not make enough money to buy insurance needed. The FDA did not take it off the market.

Don't rush into this. TRT is not ideal. I would rather not be on it.

https://www.drugs.com/vet/zeuterin-inje ... ution.html

[cutnbulls2ox (imported)]

Great detailed information CFI10000. Thanks for providing so much data on this. Both for men and for our pets. I ve been wondering about this for animal use.