Raloxifene as an adjunct to Chemical Castration

[Double22 (imported)]

Greetings all! My trial with Androcur has thus far been a great success. Since I already have a month's supply of raloxifene I was thinking about adding it to my regimen so as to reduce my Androcur dose. However, I noticed that there are no accounts of people who have added raloxifene to an already existing chemical castration regimen. I was able to find three accounts of people trying Androcur, still having libido, adding tamoxifen, and getting much better results. However, this was not the case for raloxifene, as it is a far less popular medication.

I tried getting more information from the NCBI databases, and found a large number of articles that report raloxifene exhibiting estrogenic agonism in brain tissue, where I was told that SERM's anti-libidinal action hinges on them being estrogen antagonists in brain tissue.

I'm feeling alright with my current regimen and I don't want to mess that up by adding something that could give me an estrogenic sex drive. Has anyone who tried raloxifene after a pre-existing castration regimen experienced a further decrease in libido?

Thank you for reading,

-Double22

[cboy0815 (imported)]

Should be working the same way as Tamoxifene!

[erikboy (imported)]

I was taking Androcur only for 2 weeks before I added Raloxifen. I did not notice much difference except joint pains disappeareance with start of Raloxifene. The reason why I did notice anything else was that too many changes were going on at this time.

[Double22 (imported)]

Aw yisss, just found dat good shit!

sci-hub.tw/10.1016/j.mcn.2004.04.012

The sexual behavior reported in the male ERahKO is similar tothat described for the male ArKO. ERahKO male mice alsodisplay a severe disruption of sexual behavior, including lack ofsimple mounting behavior (Ogawa et al., 2000). Reduced levels ofintromission and no ejaculation was observed in the ERaKO,while mounting behavior was not affected (Ogawa et al., 2000).Interestingly, treatment of the ERaKO males with apomorphine (adopaminergic agonist) does stimulate both male-typical copulatorybehavior and chemoinvestigatory behavior (Wersinger and Rissman, 2000), indicating that dopamine does indeed play a role inmale sexual behavior. In contrast, all aspects of sexual behaviorwere intact in the male ERhKO mouse (Ogawa et al., 2000). Theseresults suggest that while estrogen mainly asserts its effect onsexual behavior through ERa, these receptors can complementeach other to some extent in regulating male sexual behavior

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552443/

With the majority of breast cancer being luminal subtype, estrogen receptor alpha (ERα) has been the predominant targeted nuclear receptor for breast cancer treatment. To inhibit cancer progression, selective estrogen receptor modulators (SERMs), including tamoxifen have been commonly used. Although SERMs antagonize ERα function in breast, they may also impede its activity in other tissues such as bone. The resulting bone loss observed in patients undergoing adjuvant therapy, strongly implies the need for functional ERs in bone. More importantly, such hormonal therapy may indirectly affect ERα-positive cancer progression via altering activities of osteoblasts and osteoclasts. However, this microenvironmental effect remains to be investigated.

[sftineun (imported)]

Aw yisss, just found dat good shit!

sci-hub.tw/10.1016/j.mcn.2004.04.012

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552443/

Hmm. It's a bit confusing. I always understood that Tamoxifen helps slow bone loss. The second article seems to say otherwise. However, I do know that the main medical use

of Raloxifene is to slow bone loss for post menopausal women.

[sftineun (imported)]

Greetings all! My trial with Androcur has thus far been a great success. Since I already have a month's supply of raloxifene I was thinking about adding it to my regimen so as to reduce my Androcur dose. However, I noticed that there are no accounts of people who have added raloxifene to an already existing chemical castration regimen. I was able to find three accounts of people trying Androcur, still having libido, adding tamoxifen, and getting much better results. However, this was not the case for raloxifene, as it is a far less popular medication.

I tried getting more information from the NCBI databases, and found a large number of articles that report raloxifene exhibiting estrogenic agonism in brain tissue, where I was told that SERM's anti-libidinal action hinges on them being estrogen antagonists in brain tissue.

I'm feeling alright with my current regimen and I don't want to mess that up by adding something that could give me an estrogenic sex drive. Has anyone who tried raloxifene after a pre-existing castration regimen experienced a further decrease in libido?

Thank you for reading,

-Double22

I was one of the posters who shared our experience of combining Androcur with Tamoxifen and got really good results. I am currently on Raloxifene, no longer needing Androcur. While I had no experience combining Androcur with Raloxifene, Raloxifene is generally very well tolerated. As such, it is probably no riskier than Tamoxifen to combine it with Androcur. My guess is the combined effect would be similar with Tamoxifen.

[Double22 (imported)]

Hmm. It's a bit confusing. I always understood that Tamoxifen helps slow bone loss. The second article seems to say otherwise. However, I do know that the main medical use

of Raloxifene is to slow bone loss for post menopausal women.

I read a different article saying that bone actually has a mixture of ERα and ERβ. It can be noted that the women who experienced bone loss were not necessarily in menopause, but were being treated for breast cancer. This means that the comparison there was between raloxifene versus proper estrogen, and not raloxifene versus no estrogen.

[sftineun (imported)]

. .

the comparison there was between raloxifene versus proper estrogen, and not raloxifene versus no estrogen.

According to my Endocrinologist, Raloxifene is commonly prescribed to women in menopause. In fact, my mother had been on it for a long time. But it wasn't sufficient to stop her from getting osteoporosis. As such, it's effectiveness is questionable, even in women. And according to the manufacturer, no formal research had been conducted on men for this drug.