There's a comment on a blog entry about chemical castration from someone who was given DES (di-ethyl stilboestrol, a non-steroid estrogen) to chemically castrate him as a teenager in the 1950s because his parents feared he was gay because he was "more interested in Ballet than Football":
It was a matter of 'Take your pills'. It stopped me growing, but it also stopped my sex drive. Not having this at the onset of puberty meant my sexuality never developed. I got off the drug in my early twenties, as an adult, but the damage was done. I've always had a very low libido. Manage to self-stimulate about 3 times a year. Could sing soprano until about 60 years of age. Could lactate. Never had much interest in women, men, or boys. Didn't understand risque jokes. Until recently, wasn't aware that people had strong sexual agendas. Socially, it's a bit like having Aspergers syndrome. So it's a strange life, but I can concentrate on task and not be deflected. Some people don't understand what it is like to be a eunuch. In many ways, I am childish. I don't read adult books or like romantic films. I find them boring.
http://serendip.brynmawr.edu/exchange/s ... ophiliacs- (the comment is on page 2 of the comments).
DES was also widely used on women at that time and caused birth defects in the children, particularly daughters. Not sure if it's still available because it was proven to be harmful.