Effects of gnrh blockers

[erikboy (imported)]

androcur works much different way. While triptoreline basically stops your balls making testosterone, then Androcur fights its way into Testosterone receptors, replacing testosterone in there and deactivating receptors. That doesn't mean that your blood serum Testosterone levels should go down. Instead initially very complex chemistry happens in your body. Plenty of testosterone precursors is released into your bloodstream initially which works way differently from triptoreline. And different people react to Androcur differently. Androcur is considered to be one of the "dirtiest" antiandrogen with frequent sideeffects. One of them making castration permanent, while others don't feel much castration effects. Thats why it is not used for precocious puberty treatment in children.

For people who just want to kill their balls, Androcur is just fine.

[Rocket Number Nine (imported)]

For people who just want to kill their balls, Androcur is just fine.

Does it make castration permanent in the no-more-testosterone-production way? How long does one have to be on it typically for lasting ball-destruction? I have heard of these effects, and I know the longer you're on it the longer and more difficult it is for your balls to recover to normal, but I haven't really seen much in regards to permanence in things other than sterility.

[fhunter]

Does it make castration permanent in the no-more-testosterone-production way? How long does one have to be on it typically for lasting ball-destruction? I have heard of these effects, and I know the longer you're on it the longer and more difficult it is for your balls to recover to normal, but I haven't really seen much in regards to permanence in things other than sterility.

In my case - 7 months were not enough. Though I sometimes do feel weird after that. And I absolutely hated the return of testosterone, along with other effects I got from that.

[JesusA (imported)]

For people who just want to kill their balls, Androcur is just fine.

There is a reason why Androcur (Cyproterone) is not approved in North America. There is a likelihood of serious liver damage in some users. The GNRH (=LHRH) drugs, like Lupron and Zoladex are much more expensive, but they are both safer and more effective in completely shutting down testosterone production. If you decide to use Androcur because of the cost or greater availability, make certain to have your liver function tested while you are on it.

[Rocket Number Nine (imported)]

There is a reason why Androcur (Cyproterone) is not approved in North America. There is a likelihood of serious liver damage in some users.

It's also the go-to anti-androgen in most countries outside the US for specific uses, namely for MtF transgenders. All but one of the ones I know outside the US are on cyproterone. The one who isn't is on degarelix, and purely because they wanted it.

While there are liver concerns with cyproterone, and one should definitely get tested while on it, the US not approving it is more of a sign of the FDA having a flawed approval process, than it is a sign that cyproterone is inherently dangerous and should be avoided. The approval process for cyproterone in the US, furthermore, focused mainly upon its uses in relation to prostate cancer treatment, and as such, it was at a higher dose than is typically necessary for our uses. As an element in prostate cancer treatment, it of course was inferior and had more negative side effects than other existing medications, along with elevated liver strain, and as such it was denied. If they had been considering it for other uses, it would have had a significantly higher chance of being approved.

There are all sorts of messed up things that have made their way through the FDA approval process. I would take their approval or disapproval of anything with a grain of salt, and look thoroughly into their process, before considering it gospel.

[Jorge2008 (imported)]

In my case Cyproterone had virtually no effect on my sex drive, but triptoreline was quite effective.

I had my testosterone level monitored on cyproterone and it was still pretty high on it (100mg - still about half of the minimum normal blood level). Only triptoreline managed to lower it to almost zero.

[C/D gweny (imported)]

what actually is "fincar 5" doing is it also a blocker , as my doctor put me on this drug ? ask GWENY

[experiment (imported)]

From what I have read, triptoreline is very strong. It seems to shut down all testosterone production including the pituitary as well as the testis. Unfortunately I see it is only available as an injection, not pill form. I have no doubt that taking it in combination with cyproterone would leave you impotent and sterile within a week or two of starting treatment

[aspie_nico (imported)]

Unfortunately I see it is only available as an injection, not pill form.

Its a good thing if you have a doctor that can inject it every three months. I have to take enough pills. I am happy I dont have to take more pills.

I have no doubt that taking it in combination with cyproterone would leave you impotent and sterile within a week or two of starting treatment

It seems nothing is making me completely impotent not even the combination androcur and triptoreline. But libido is zero...

[experiment (imported)]

Are you still on 100 mg of cyproterone? How long have you been taking both Androcur and Triporeline? surprised at your results thusfar