Have any of you guys tried Silodocin? It is meant to treat prostate enlargement but the side effect is that pretty much 100% of the people taking it can no longer ejaculate -- basically you can still orgasm but nothing will come out. This is due to it relaxing the muscles around the prostate.
Although many articles use the term "retrograde ejaculation", that is a misnomer as it seems to be simply no ejaculation (regular or retrograde)
It is considered very well tolerated.
Apparently it may also help with premature ejaculation: http://www.ncbi.nlm.nih.gov/pubmed/22188258 and http://www.taipeitimes.com/News/taiwan/ ... 2003541072
Silodocin for preventing ejaculation
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SplitDik (imported)
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CastratedTomcat (imported)
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Re: Silodocin for preventing ejaculation
Hello, yes, I'm using it any times.
Yes, it made an no ejaculation, not a retrograde ejaculation, this is absolute right.
The prostata does simply not work at the orgasm.
It's a very very nice effect and the orgasm is vary between more intense and very low intense feeling over the time where the drug is working.
With 1/3 of the dose of one capsule you will have around one day no chance to squirt.
With a whole capsule you will have two days fun.
If dou don't have eat before, it will work in one hour.
You will feel a bad feeling in the stomach. If you use it with eat you can prevent this feeling, but it needs longer to work.
Only it has a very negative side on me, it made a stuffy nose and I have to use a nosespray at night.
Yes, it made an no ejaculation, not a retrograde ejaculation, this is absolute right.
The prostata does simply not work at the orgasm.
It's a very very nice effect and the orgasm is vary between more intense and very low intense feeling over the time where the drug is working.
With 1/3 of the dose of one capsule you will have around one day no chance to squirt.
With a whole capsule you will have two days fun.
If dou don't have eat before, it will work in one hour.
You will feel a bad feeling in the stomach. If you use it with eat you can prevent this feeling, but it needs longer to work.
Only it has a very negative side on me, it made a stuffy nose and I have to use a nosespray at night.
Re: Silodocin for preventing ejaculation
Text from link 1:
Premature ejaculation is a common sexual problem, as is erectile dysfunction. We evaluated silodosin, a highly selective α1A-adrenoceptor antagonist, as a new treatment option for premature ejaculation. α1-Adrenoceptor antagonists are widely used for lower urinary tract symptoms, and clinical studies on silodosin have shown excellent clinical efficacy for lower urinary tract symptoms. However, compared with other α1-adrenoceptor antagonists, silodosin appeared to suppress ejaculation in a relatively higher percent of trial participants. This suppression of ejaculation by silodosin suggested its potential for treating premature ejaculation. Consequently, we evaluated the feasibility of off-label silodosin as a new treatment option for premature ejaculation. Eight patients suffering premature ejaculation were treated with silodosin. Silodosin (4 mg) was given 2 h before sexual intercourse. Intravaginal ejaculatory latency time, premature ejaculation profile item, clinical global impression change in premature ejaculation and systemic adverse events were recorded. Intravaginal ejaculatory latency time was significantly prolonged (from 3.4 min to 10.1 min, P = 0.003). All patients answered better (much better) or slightly better for their own premature ejaculation problem compared with pretreatment condition in the clinical global impression change. Premature ejaculation profile also significantly improved. Two (25%), three (37.5%) and seven patients (87.5%) experienced anejaculation, reduced semen volume and discomfort during orgasm, respectively. However, these problems were not of major concern for the participants. No systemic adverse effects were reported. The current results support the possible use of silodosin as a new treatment option for premature ejaculation, and suggest that a placebo controlled study assessing its clinical usefulness would be worthwhile.
© 2011 The Japanese Urological Association.
Link 2:
Silodosin, a prescription medicine used to treat an enlarged prostate, can prolong the length of time it takes to ejaculate, a study conducted by Stephen Yang (楊緒棣), surgeon-in-chief at Buddhist Tzu Chi General Hospital’s Taipei Branch, has suggested.
The study involved 26 sexually active patients who had taken Silodosin for the treatment of benign prostatic hyperplasia over the period of six-and-a-half months.
The results showed that average intravaginal ejaculation latency time (IELT), which means the time between the start of vaginal intromission and the start of intravaginal ejaculation, in men who took the drug increased from four minutes to 5 minutes, 48 seconds, with seven men saying their IELT was greatly extended, while eight men said they felt no significant difference.
The average age of the patients was 56 years old.
In Taiwan, one in every two men aged 50 or older has an enlarged prostate, Yang said.
Silodosin is also said to work for younger men.
In one study conducted in Japan, eight men in their 30s who suffered from premature ejaculation reported that their average IELT increased from three minutes to 10 minutes, with six saying the improvement was “significant,” Yang said.
Yang’s study also suggests the drug works better for those who suffer from premature ejaculation, extending their IELT from 1 minute, 30 seconds to three minutes.
The average time for those without the problem increases from five minutes to 6 minutes, 48 seconds, he said.
Yang said it is clinically understood that a premature ejaculation happens less than two minutes after penetration, while the IELT needs to be three minutes or longer for women to “feel satisfied.”
The physician said he was interested in looking into the effects of the drug after hearing the reactions of patients who had taken it.
“One day, a woman came in with her 65-year-old husband and asked what kind of medicine I had prescribed him because it made him able to have sex for 30 minutes. Soon the same thing happened with another patient who was 63 years old. Then I knew something was not right,” said Yang, who is also a professor of urology at Tzu Chi University in Hualien City.
Having been developed and received its first marketing approval in Japan in 2006, Silodosin has been available in Taiwan since last year.
Another interesting finding, Yang said, is that the drug provides evidence that the male orgasm is not necessarily connected with the occurrence of ejaculation.
As Silodosin has the ability to block seminal vesicles from secreting and thus preventing the release of semen, half of the patients in the study had no ejaculation, while 47 percent had a decreased sperm count.
However, 97 percent of the subjects reported having an orgasm.
Citing studies conducted in Japan, Yang said Silodosin is completely effective in inhibiting ejaculation as no sperm is detected in the samples provided by volunteers in the studies.
“The drug has the potential to be used as a means of male birth control, but we also need to understand that younger men have a different perception of sex than older men,” the researcher said.
“To them, it is psychologically important to have an ejaculation,” he said.
Both medical studies and clinical experience show that the effect of inhibiting ejaculation is reversible.
Patients can resume the normal ejaculatory function after they stop taking Silodosin for two to three days, Yang said.
Premature ejaculation is a common sexual problem, as is erectile dysfunction. We evaluated silodosin, a highly selective α1A-adrenoceptor antagonist, as a new treatment option for premature ejaculation. α1-Adrenoceptor antagonists are widely used for lower urinary tract symptoms, and clinical studies on silodosin have shown excellent clinical efficacy for lower urinary tract symptoms. However, compared with other α1-adrenoceptor antagonists, silodosin appeared to suppress ejaculation in a relatively higher percent of trial participants. This suppression of ejaculation by silodosin suggested its potential for treating premature ejaculation. Consequently, we evaluated the feasibility of off-label silodosin as a new treatment option for premature ejaculation. Eight patients suffering premature ejaculation were treated with silodosin. Silodosin (4 mg) was given 2 h before sexual intercourse. Intravaginal ejaculatory latency time, premature ejaculation profile item, clinical global impression change in premature ejaculation and systemic adverse events were recorded. Intravaginal ejaculatory latency time was significantly prolonged (from 3.4 min to 10.1 min, P = 0.003). All patients answered better (much better) or slightly better for their own premature ejaculation problem compared with pretreatment condition in the clinical global impression change. Premature ejaculation profile also significantly improved. Two (25%), three (37.5%) and seven patients (87.5%) experienced anejaculation, reduced semen volume and discomfort during orgasm, respectively. However, these problems were not of major concern for the participants. No systemic adverse effects were reported. The current results support the possible use of silodosin as a new treatment option for premature ejaculation, and suggest that a placebo controlled study assessing its clinical usefulness would be worthwhile.
© 2011 The Japanese Urological Association.
Link 2:
Silodosin, a prescription medicine used to treat an enlarged prostate, can prolong the length of time it takes to ejaculate, a study conducted by Stephen Yang (楊緒棣), surgeon-in-chief at Buddhist Tzu Chi General Hospital’s Taipei Branch, has suggested.
The study involved 26 sexually active patients who had taken Silodosin for the treatment of benign prostatic hyperplasia over the period of six-and-a-half months.
The results showed that average intravaginal ejaculation latency time (IELT), which means the time between the start of vaginal intromission and the start of intravaginal ejaculation, in men who took the drug increased from four minutes to 5 minutes, 48 seconds, with seven men saying their IELT was greatly extended, while eight men said they felt no significant difference.
The average age of the patients was 56 years old.
In Taiwan, one in every two men aged 50 or older has an enlarged prostate, Yang said.
Silodosin is also said to work for younger men.
In one study conducted in Japan, eight men in their 30s who suffered from premature ejaculation reported that their average IELT increased from three minutes to 10 minutes, with six saying the improvement was “significant,” Yang said.
Yang’s study also suggests the drug works better for those who suffer from premature ejaculation, extending their IELT from 1 minute, 30 seconds to three minutes.
The average time for those without the problem increases from five minutes to 6 minutes, 48 seconds, he said.
Yang said it is clinically understood that a premature ejaculation happens less than two minutes after penetration, while the IELT needs to be three minutes or longer for women to “feel satisfied.”
The physician said he was interested in looking into the effects of the drug after hearing the reactions of patients who had taken it.
“One day, a woman came in with her 65-year-old husband and asked what kind of medicine I had prescribed him because it made him able to have sex for 30 minutes. Soon the same thing happened with another patient who was 63 years old. Then I knew something was not right,” said Yang, who is also a professor of urology at Tzu Chi University in Hualien City.
Having been developed and received its first marketing approval in Japan in 2006, Silodosin has been available in Taiwan since last year.
Another interesting finding, Yang said, is that the drug provides evidence that the male orgasm is not necessarily connected with the occurrence of ejaculation.
As Silodosin has the ability to block seminal vesicles from secreting and thus preventing the release of semen, half of the patients in the study had no ejaculation, while 47 percent had a decreased sperm count.
However, 97 percent of the subjects reported having an orgasm.
Citing studies conducted in Japan, Yang said Silodosin is completely effective in inhibiting ejaculation as no sperm is detected in the samples provided by volunteers in the studies.
“The drug has the potential to be used as a means of male birth control, but we also need to understand that younger men have a different perception of sex than older men,” the researcher said.
“To them, it is psychologically important to have an ejaculation,” he said.
Both medical studies and clinical experience show that the effect of inhibiting ejaculation is reversible.
Patients can resume the normal ejaculatory function after they stop taking Silodosin for two to three days, Yang said.
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kazman0608 (imported)
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Re: Silodocin for preventing ejaculation
I had to take some medication once before after I had a urethral scope done. Forget what it was but it did lower libido just a tad but the one effect was the retrograde ejaculation which meant that the semen went into the bladder.