Testosterone Risks

[butterflyjack (imported)]

There has been no mention of these eunuch risks being abated by the use of estrogen replacement...I'm seriously contemplating castration ..I take 5mgs daily of finasteride and 2 mgs daily of estrofem...Would continued use of the estrogen help allay some of the bad aspects of eunchry ?? I really don't want any manly T stuff raising any ugly heads..Anyone with any answers?? Thanks Jackie

[JesusA (imported)]

Going in the opposite direction – the addition of testosterone to supplement what an intact male is producing – here is a piece from the Clinical Trials Update column of the Journal of the American Medical Association:

Testosterone Therapy Boosts MI Risk

Anita Slomski

Journal of the American Medical Association. 2014; 311(12):1191. doi:10.1001/jama.2014.3044.

Men treated with testosterone therapy (TT) are at substantially increased risk of acute myocardial infarction (MI), concluded authors of a cohort study of 55 593 men (Finkle W et al. PLoS One. doi:10.1371/journal.pone.0085805 [published online January 29, 2014]).

Men aged 65 years and older doubled their risk of MI within 3 months of filling an initial TT prescription. Younger men with a history of heart disease doubled or tripled their risk of MI within 90 days, but risk did not increase in younger men without heart disease.

The authors expressed concern that use of TT is rapidly increasing, including among younger men. In this study, 10% of the younger men taking TT had a history of heart disease.

Until clinical trials provide evidence of the risks and benefits of TT, "clinicians might be well advised to include serious cardiovascular events in their discussions with patients of potential risks, particularly for men with existing cardiovascular disease," the researchers said.

[janekane (imported)]

I suppose it is time to mention the use of estrogen and progesterone to reduce the risks associated with testosterone reduction post-orchiectomy. Somewhat after my orchiectomy, I did, which fact I have mentioned previously in Archive posts, seek out an endocrinologist who prescribed those for me. My brain response to my orchiectomy was, "At last! Hurray." My brain response to the estrogen and progesterone was also, "At last! Hurray!"

As for the resulting gynecomastia, my brain response was, regarding whatever form of BIID I may have, "At last! Hurray!"

From my understanding of biology, I had long suspected that testosterone supplements might lead to circulatory system problems, which is why, in part, I never entertained any form of post-orchiectomy testosterone replacement.

Luckily for me, given my understanding of biology, I find that the only accurate cause of death that a pathologist can truthfully put on a death certificate is, "conception." Haploid gametes and diploid cells means death after life.

Luckily for me, given my understanding of biology, life is made of death no more nor less than death is made of life; therefore, whether I am alive or have died, I remain an aspect of life?

So, I figure that I am in the ride of my life, with a little control over it.

As what is, is; and as what isn't isn't, I choose to be satisfied with what is, as it is.

Post script: "

risk did not increase in younger men without heart disease

" cannot actually be true, methinks. What I am willing to allow is that measured risk did not increase. Here, my grasp of semiotics and biosemiotics announces itself.

Semiotics is the science of the relationships of signs to what the signs signify. No sign can be what it signifies. Therefore, the measured risk over the duration of a study is not the actual risk the person has, because it may take longer than the duration of the study for the risk to become measurable.

Had I never been conceived, I would not have the problems of my life?

If I do not have any problems, can I be other than in the place of perdition?

[A-1 (imported)]

But I like my red sports car!

Mine is BLUE... but the GTO was yellow... in its day...

Going in the opposite direction – the addition of testosterone to supplement what an intact male is producing – here is a piece from the Clinical Trials Update column of the Journal of the American Medical Association:

Testosterone Therapy Boosts MI Risk

Anita Slomski

Journal of the American Medical Association. 2014; 311(12):1191. doi:10.1001/jama.2014.3044.

Men treated with testosterone therapy (TT) are at substantially increased risk of acute myocardial infarction (MI), concluded authors of a cohort study of 55 593 men (Finkle W et al. PLoS One. doi:10.1371/journal.pone.0085805 [published online January 29, 2014]).

Men aged 65 years and older doubled their risk of MI within 3 months of filling an initial TT prescription. Younger men with a history of heart disease doubled or tripled their risk of MI within 90 days, but risk did not increase in younger men without heart disease.

The authors expressed concern that use of TT is rapidly increasing, including among younger men. In this study, 10% of the younger men taking TT had a history of heart disease.

Until clinical trials provide evidence of the risks and benefits of TT, "clinicians might be well advised to include serious cardiovascular events in their discussions with patients of potential risks, particularly for men with existing cardiovascular disease," the researchers said.

Watch late night T.V. on satellite and learn what the shyster attorneys can sue testosterone producers for when you become a statistic... provided you live through the crisis... something to do in ICU after they remove the breathing tubes and the feeding tubes... you cannot do much else...

The list is quite impressive...

[jcat (imported)]

Well I "was" on T-supplements (Testopol) but last week diagnosed with prostrate cancer. I see my Uro on Tuesday. I assume my T replacement days are over...

g

I have had prostate problems for some time and recently looks like flaring up again. I have been doing some reading and found some interesting research:-

http://www.sciencedaily.com/releases/20 ... 121353.htm

http://www.medivo.com/blog/low-testoste ... te-cancer/

https://www.lef.org/magazine/mag2008/de ... cer_01.htm

Here is another one:

http://www.livescience.com/36491-testos ... -risk.html

From the evidence it looks like a case of if you have it in you, low testosterone could be a trigger and T replacement will make no difference! Interestingly my PSA has gone up as my T levels have gone down.

[daifu-orchid (imported)]

Jesus would appear to be right. The evidence supporting increased cardiovascular risk with super-normal T seems repeatedly sound. I just wonder at the moneytree that has come from agressively marketed transdermal T.

Are the patients fully informed? They should be. Are the T levels appropriately verified before supplementation? There seems mounting opinion, though without hard evidence as yet, no.

Questions of ethics, freedom and economics are only the start....

[janekane (imported)]

The historical medical evidence of cardiovascular risk at supposedly normal testosterone levels was well established, if one knew where in the medical literature to look, by the 1950s.