Siterone question

[de_fens_us (imported)]

I'm sure this question has been addressed in the forum but please help me understand. If I understand correctly Siterone blocks the body's ability to use testosterone. I also understand this drug will cause your testicles to produce less and less testosterone and eventually shrink and quit making testosterone altogether.

I guess I just don't understand this. Seems to me like your body would sense this lack of ability to use testosterone it is craving and would signal the testicles to produce more and more testosterone instead of shutting them down.

Anyone help explain this to me??

[fhunter]

I'm sure this question has been addressed in the forum but please help me understand. If I understand correctly Siterone blocks the body's ability to use testosterone. I also understand this drug will cause your testicles to produce less and less testosterone and eventually shrink and quit making testosterone altogether.

I guess I just don't understand this. Seems to me like your body would sense this lack of ability to use testosterone it is craving and would signal the testicles to produce more and more testosterone instead of shutting them down.

Anyone help explain this to me??

This works like this:

1. Siterone binds to the same receptors as testosterone, thus mimicking the testosterone action. Testosterone can not bind to the receptors occupied by siterone.

2. Body, seeing this gets a signal - too much testosterone. Testosterone production drops lower, receptors are still occupied by siterone.

3. (As far as I think, correct me please if this is not so) The regulation loop works good for quick changes in levels, but not for long term ones.

[kristoff]

The primary male sex hormone is testosterone. Testosterone, a steroid, is made by the interstitial, or Leydig, cells of the testes. Production and secretion of testosterone increases sharply at puberty and causes the development of the secondary sexual characteristics (e.g., beard, genital enlargement) of men. Testosterone is also essential for the production of sperm.

Production of testosterone is controlled by the release of luteinizing hormone (LH) from the anterior lobe of the pituitary gland, which is in turn controlled by the release of GnRH (Gonadotropin Releasing Hormone) from the hypothalamus. LH is also called interstitial cell stimulating hormone (ICSH). Thus:

Hypothalamus --> GnRH --> Pituitary --> LH --> Testes --> Testosterone

The level of testosterone is under negative feedback, that is, a rising level of testosterone suppresses the release of GnRH from the hypothalamus.

The result of the drug reduces or eliminates the GnRH and thus stops the production of testosterone.

[de_fens_us (imported)]

Thanks for the information. My question has been answered.