Lupron

[erikboy (imported)]

Has anyone had chem castration experience with Lupron?

In theory with lupron there should be less side effects.

[JesusA (imported)]

Lupron is the pharmaceutical of choice in North America for the chemical castration of prostate cancer patients. It's a very expensive alternative, but it does seem to have fewer side effects and requires shots only about once every three months. I have not checked the medical literature on it, but there should be plenty of information available.

[kristoff]

Has anyone had chem castration experience with Lupron?

In theory with lupron there should be less side effects.

Check some of the old posts by Guy26. I believe he was doing something with Lupron

[Jorge2008 (imported)]

Also, I'd be glad if anyone commented on the use of any other GnRH agonists, like Buserelin. It seems my doctor is considering those.

Has anyone had chem castration experience with Lupron?

In theory with lupron there should be less side effects.

[erikboy (imported)]

So, generally about GnRH agonists. Or difference compared to androcur.

It takes longer for castration effects to kick in. There is also initial increase in T-levels and T-related effects during the first week. In a month T-levels drop to castrate levels.

There is no hot flashes.

There is less problems with estrogen/testosterone disbalance like gynecomastia.

There is no liver poisoning

depending on depo substance you need only one shot per one or even three months. There is also subcutaneous depo available for a full year.

Returning to normal T-levels after treatment takes much longer time. at least 3 months but could take as long as 1 year, which is considered normal.

It seems like long term usage is not causing significant permanent damage. By Long I mean, being on treatment for 5-7 years.

Lupron is preferred medicine for precocious puberty treatment. And most of the data above is from medical journals, surveys etc. dealing with precocious puberty.

[kristoff]

So, generally about GnRH agonists. Or difference compared to androcur.

It takes longer for castration effects to kick in. There is also initial increase in T-levels and T-related effects during the first week. In a month T-levels drop to castrate levels.

There is no hot flashes.

There is less problems with estrogen/testosterone disbalance like gynecomastia.

There is no liver poisoning

depending on depo substance you need only one shot per one or even three months. There is also subcutaneous depo available for a full year.

Returning to normal T-levels after treatment takes much longer time. at least 3 months but could take as long as 1 year, which is considered normal.

It seems like long term usage is not causing significant permanent damage. By Long I mean, being on treatment for 5-7 years.

Lupron is preferred medicine for precocious puberty treatment. And most of the data above is from medical journals, surveys etc. dealing with precocious puberty.

Remember that treating precocious puberty is not the same thing as castration for a fully developed male. You WILL experience the same side effects as the person who has a surgical castration. You will likely have hot flashes (cold ones too), weight gain, osteoporosis risk elevated, lower energy levels, muscle loss, etc etc. You know what they are. For the precocious they are stopping things before they get too far - there hasn't been the same opportunity for development of all the testosterone related effects of growing up.

[foxytaur (imported)]

Warning = Leuprolide therapy in conjunction with radiation has been shown to result in a statistically significant shortening of the penis.

[Jorge2008 (imported)]

Yeah, I've read this too. Fortunately I'm not gonna be on radiation therapy. But yes, I dislike the idea that my cock might get smaller when on a GnRH agonist - there might arise opportunities to finally use my male privities one day in the future, lol.

Warning = Leuprolide therapy in conjunction with radiation has been shown to result in a statistically significant shortening of the penis.

[erikboy (imported)]

Remember that treating precocious puberty is not the same thing as castration for a fully developed male. You WILL experience the same side effects as the person who has a surgical castration. You will likely have hot flashes (cold ones too), weight gain, osteoporosis risk elevated, lower energy levels, muscle loss, etc etc. You know what they are. For the precocious they are stopping things before they get too far - there hasn't been the same opportunity for development of all the testosterone related effects of growing up.

Regarding general castration effects, boys that have precocious puberty experience almost the same like all other males. For example testicular atrophy is reported in studies. And probably they will loose their libido too. All the known effects of castration.

About osteoporosis I don't know. that is not reported. But kids bones are different too, they contain less calcium as I can remember from other materials i have read. About energy I should agree, that kids have plentiful of it even without T. And probably adults feel loss of energy more seriously. Still some energetic reduction or change must happen even in case of precocious puberty.

There is an interesting case of identical twins, where one of boys is transgendered and had his puberty stopped. There you could easily notice less muscle mass, smaller stature, little bit rounder general look. Age 14 - http://cache.boston.com/resize/bonzai-f ... 4/539w.jpg

Their name was Maines I think.

Lack of hot flashes is explained the way GnRH agonists act. While Androcur blocks T-receptors, inducing Testosterone deficit, hormonal system tries to upregulate T production by releasing more GnRH, LH and FSH, which overstimulates adrenal gland which causes hot flashes. GnRH agonists induce downregulation of GnRH production and there is no attempt by hormonal system to stimulate T-production like it happens with androcur or physical castration. And there is no hot flashes.

If someone has used Lupron, I would be happy to hear comments.

[experiment (imported)]

Had an inlaw who was on Lupron for 2 years with a shot every 3 months and radiation for 6 months. He is now pretty much chemically castrated. After 6 months there is no sign of testosterone production and he is not a candidate for T replacement.

He experienced all the negative side effects, night sweats, chills, weight gain, etc. Not a pleasant condition, but there is little that can be done.