Calcium Chloride and Other Salt Injections for Castration

[SplitDik (imported)]

Reading more about this method in the linked papers, it promises to be a much more painless and certain method because it works by disrupting cell regeneration -- it doesn't immediately do damage. Instead it causes apoptosis (programmed cell death) by disrupting the ability of the testicle cells to regenerate. So the process takes about four weeks, with the cells slowly being lost and not coming back. Then once the testosterone-generating cells are weakened, the atrophy is accelerated because much of the testicle structures only regenerate in the presence of testosterone.

From

http://www.stray-afp.org/nl/wp-content/uploads/2012

/09/CaCl-2006-Jana-calcium-chloride-rats.pdf:

The degeneration of germ cells in the CaCl2-treated testis

is possibly mediated by apoptosis. This is supported by the

appearance of some multinucleated giant cells in the

seminiferous tubules, as it is an important feature of germ

cell apoptosis [42,43]. Apoptosis of testicular germ cells by

CaCl2

treatment is further supported by the sloughing of

immature germ cells (shed cells) in the intraluminal space

[42]. Moreover, the appearance of exfoliated germ cells in

the seminiferous epithelium is also an indication that germ

cells are undergoing apoptosis, which is consistent with other

findings [43]. Germ cell detachment from the basal lamina

also indicates the induction of apoptosis in testicular tissue,

which is supported by others [42,44]. Apoptosis of germ

cells in the testis is possibly due to the low concentration of

testosterone, as testosterone is a cell survival factor for germ

cells in the testis, and withdrawal of testosterone induces

apoptosis in testicular germ cells [45]. Reduced concentration of intratesticular testosterone activates testicular caspase-3 activity, which is associated with germ cell apoptosis

[46]. Moreover, the apoptotic property of CaCl2 through the

induction of caspase-3 activity was also reported by others

[47]. It is important to note that necrosis and apoptosis can

occur simultaneously [48], and, after that, apoptotic cells

undergo secondary necrosis [49].

Another way in which testicular degeneration was noted

by CaCl2 may be through the generation of reactive oxygen

species (ROS) or their products in testicular tissue, as ROS

production in the testis results in a low level of testosterone,

which is associated with germ cell degeneration [50,51].

Calcium chloride is also an effective chemical agent for

inducing the generation of ROS in tissues [52]. This is

supported by the appearance of giant cells in seminiferous

tubules in the treated group, and these giant cells are also

actively engaged in free radical production [53]. Calcium

chloride-induced testicular oxidative stress can be assessed

by the measurement of MDA [54]. The fact that an

intratesticular injection of CaCl2 was associated with freeradical production in the testis was reflected by the high

testicular content of MDA. Free-radical production in the

testis of treated rats is supported by the infiltration of

leucocytes in the seminiferous tubules, as testicular freeradical production is closely associated with leucocyte

infiltration [55].

This elevation in the formation of free radicals in the

testes treated with CaCl2 is also supported by the diminution

in testicular GPx, SOD and GST activities, as these are

considered important scavenging enzymes against free

radicals in male gonads [56,57]. Besides these enzymatic

antioxidants, CaCl2 treatment was also associated with a low

content of testicular reduced GSH, an important nonenzymatic antioxidant in the testis [58]. The low activities of

testicular GPx, SOD and GST along with a low content of

GSH among the treated rats may be due to the low

concentrations of testosterone [50,51] or the direct effect of

CaCl2

, which is not explored properly in this study. It may be

assumed that testicular degeneration in this experiment was

due to generation of free radicals in the testis, as free radicals

are inhibitors for spermatogenesis [19] and testicular

androgenesis [59]. In addition, the reduced levels of GST

activity and GSH content in the testes would be another

cause for the degenerative necrosis of seminiferous tubules.

Glutathione S-transferase and GSH are important regulators

for proliferation and differentiation of germ cells and provide

protection to germ cells against the harmful effects of free

radicals [60]. However, Bauche et al. [61] showed that

Sertoli and peritubular cells have a high content of GSH and

a higher activity of GST. Degeneration of these cells by

CaCl2 treatment could be a possible cause for the lower

content of GSH and GST activity in the treated testis.

Rapid production of ROS results in DNA fragmentation, protein degradation that may lead to germ cell

K. Jana, P.K. Samanta / Contraception 73 (2006) 289 – 300 297apoptosis [57]. Besides this, improper functioning or

diminution in the activities of GPx, GST, SOD and content

of GSH in testis may also lead to germ cell apoptosis, as

these enzymes act as an anti-apoptotic factor [57,62–64]. In

CaCl2-treated rats, the diminution in prostato-somatic,

seminal vesiculo-somatic and epididymal somatic indices

may be due to low plasma concentration of testosterone, as

growth of these accessory sex organs is solely controlled by

testosterone [65]. Moreover, the low plasma concentration of

testosterone in CaCl2-treated rats has been further indicated

here by significant diminution in epididymal sperm count, as

sperm maturation in the epididymis is controlled by

testosterone [38]. Peritubular space in testicular sections of

CaCl2-treated rats also exhibited significant degenerative

changes along with proliferation of fibrous tissue. Such

changes may be due to the low level of plasma testosterone

[66]. Moreover, fibrosis of peritubular space in treated

animals is also consistent with previous studies on other

chemical agents [6,12]. The infiltration of leucocytes into the

tubular and peritubular zones is possibly due to the

degeneration of germ cells, which may release a large

amount of proteins that defuse out to the luminal cavity of

the seminiferous tubule and into the interstitium where they

act as antigen to promote chemotaxis of leucocytes [13].

Note I've been contacted by two people recently. One was injected on Monday and another will be today. They're logging their experiences, including video/photos, and assuming they are really doing it I should have something to post in about a month. Note the guy that did it on Monday said there was no pain at all during the injection, on the second day it felt like having "blue balls" but no serious pain, and today back to painless.

[dvdbll (imported)]

SplitDik - Do you know where they got the solution? I can only find low % solutions for sale on-line and it looks like you need 20% to do it right, correct? I guess I could make it, but I don't have a scale to measure the salt.

[artisticlicense (imported)]

The video link in my original post doesn't work, but same video can be found here

: http://www.pa

rsemusfoundation.org/Parsemus/Nonsurgical_dog_

%26_cat_sterilization-_males.html

Also, here is a bovine study with a picture of the testicles af

ter -- apparently shrunk down to 34g at slaughter time.

http://www.parsemusfoundation.org/Parse ... les_files/

1978%20ModVetPract59.2.119.pdf

Cruising through and noticed your posting. Went to the Parsemus site, and discovered a survey that I think a lot of members might want to visit; especially since it is a chance to 'tell their story' or a least let pharmaceutical companies and method developers know that there may be a huge or a least a larger "market" for their potions, pills and chemicals.

It is also a chance to let the world know that there is a larger than thought-of population of guys who want to be sterile, or eunuchs.

http://www.newmalecontraception.org/

Survey page; http://malecontraceptives.org/new_activism.php

[SplitDik (imported)]

SplitDik - Do you know where they got the solution? I can only find low % solutions for sale on-line and it looks like you need 20% to do it right, correct? I guess I could make it, but I don't have a scale to measure the salt.

I posted a link to a cheesemaking liquid calcium chloride available on Amazon. If you google more about that manufacturer they say it is 30 to 37%. I bought some and tasted it and it is very strong and burns the tongue a bit. So definitely not weak.

[SplitDik (imported)]

Okay, I'm going to start posting the semi-daily blog of a guy who claims to have been injected on this past Monday. I have been in communication with him for quite a while and he is in the category of an otherwise sane, successful guy who has been plagued with an oversexed libido. He's married, happily, with kids but also has been seeing a semi-pro domme , "Ruby", who was willing to do extreme CBT and he was able to convince to try castration on him. She tried burdizzo but they didn't go through with it as it was too painful.

He says that the woman who injected him has video of it and he'll post it soon as well as the follow up to the end of the six weeks or whenever it is clear that it has achieved castration. I would ask people to use your own judgement on whether you think it is real, until we see proof, since there are lot of people with rich fantasies.

These are excerpts of e-mail I'm exchanging with him.

Oct. 31:

Met with Ruby for sushi with goal of discussing plans for castration. Had a good lunch, and afterwards in the parking lot I had a long talk. I showed her the calcium chloride I had bought. She asked me if I was sure I wanted to go through with it, and when I said yes, she brightened up and said “I’d love to be the one to castrate you!”

[SplitDik (imported)]

More correspondence over past couple days:

Nov 4:

Had a hard time sleeping last night. Realized this might be the last day in my life I’ve got working balls. My wife gave me oral last night and as she was sucking my balls I was wondering how long before she’ll notice them shrinking.

Ruby texted me asking what I wanted her to wear for my castration. I asked her to wear her hair down and to wear a grey skirt outfit I saw her in once. She said “I cannot wait for tomorrow” -- her enthusiasm is really contagious, although it is also what has led me to this point -- when you have a young (she’s only 25), beautiful (I’ll send you video when I compile it) girl actually expressing enthusiasm to castrate you there is not really any way for a guy like me to say no.

Nov. 5:

Barely slept a wink last night, last night with my balls? I didn’t have sex though as my wife had her period and I didn’t masturbate because I wanted to have maximum horniness. Last night with intact balls … its a really weird feeling.

Driving over I was in a very strange place mentally. Part of me wanted to just bail, or even call my wife to say “help”, but another part of me felt the weight of my entire life leading me to this point. I decided that I would go with the flow -- if Ruby was up for doing it, then I would do it. Turns out she was certainly up for it.

We met at a Starbucks. She looked really hot in a professional sort of way -- grey skirt, high heels. She turned heads. She’d already bought me an Americano.

At this point, it was obvious we were both up to do the deed. She didn’t ask if I wanted to do it, just took me to her car. We drove to an adjacent Target parking lot which was pretty dead as it was only 8:30am. Then we got into her back seat. I was going to get castrated in the backseat of a car in a Target parking lot!

She wanted to video the whole thing, and also video blog the results over the next few weeks, and I’ll send the whole thing once I get the clips from her.

She made the whole thing really erotic. She wanted to have me slowly undress, she admired my cock and balls. She positioned us so that the light would give us the best video. Then she got down to business..

She is an EMT and has a lot of experience with needles. The only thing was that the only needles she had were insulin type which only hold 0.5cc and have short needle. So we decided that instead of one long shot inserted from the bottom of each testicle that she would do several shots from the sides.

We also decided that if it hurt a lot we’d stop. I wanted her to do both testicles at the same time so that I couldn’t chicken out after just one, but it wasn’t practical to position two needles at the same time.

We tasted the calcium chloride -- it burned the tongue for just an instant and then left an aftertaste that actually tasted slightly like milk.

Then she just started right in and I didn’t stop her. She inserted the needle and really I couldn’t even feel it. She started slowly pressing in the plunger, and I was surprised that I couldn’t feel it at all. She was making the whole thing kind of erotic, and asking me about how it felt (you’ll see this on the video), and so I said it tingled to keep her excited but actually I didn’t even notice anything.

Since it didn’t hurt, I didn’t stop her. She alternated testicles, with four shots each of 0.5cc into different locations. That was it.

We were worried that there might be some immediate adverse health effect, maybe allergic reaction or heart palpitations, so she wanted to wait with me for an hour. The cool thing was that she started kissing me, and it was really nice. It was our first kiss. She let me see her pink lace panties, but I didn’t feel the time was right to actually go for a sexual encounter. Then we just hugged and talked about her life, and after a bit it was clear that I was fine so I headed off to work.

My feeling through the whole day was euphoric. It was a huge psychological relief to actually have fulfilled my lifelong obsession. And the fact that it didn’t hurt was amazing, because I firmly had prepared myself for days fo excruciating recovery. It was a huge rush to be at work talking to hot female co-workers and have this secret that my balls were dying, something they’d never suspect.

After a couple hours, the testicles were hard as rocks. They did get a bit tender, but not in a way that hurt on their own -- only when I tried to directly manipulate them. I would consider it painless at the moment.

I kept Ruby posted throughout the day, and gives me encouraging texts. When I said my balls were rock hard but without pain she sent “Awesome!”. Later she texted “I really liked kissing you. It felt amazing. I loved every minute of it.”

We are planning to meet up every week so she can monitor the progress. Again she is so enthusiastic: “I can’t wait to see!”.

[SplitDik (imported)]

And latest:

Nov. 6

Almost a full day into my castrated life, still doing well. My right ball got tender, but after massaging it it is fine. They are really hard, and I can actually feel them bump into each other as I walk. My wife didn’t notice anything though - they look pretty normal.

I feel different already. Probably just a placebo effect, but I suppose it could be effect of diminishing hormones.

Ruby continues to encourage me as I send her updates and she is obviously curious: “So do they still feel warm? Are they shrinking? I love that I’m getting to be a major part of this huge event in your life. I’m honored to do so.”

She asked me “What are you most looking forward to about being castrated.” I said “I’m looking forward to being free from horniness. All my life all I can think about is chasing pussy. That is fun but when you can’t work or sleep or drive because every pretty woman catches your eye, eventually you want a rest. Also, having big balls and cock between your legs is also distracting -- constant erections you can’t ignore.” Again she was supportive: “Makes perfect sense. I like your huge cock and balls. I’m a bit jealous of your wife. I’ll admit it. I like being horny, but ya it gets me into trouble and I’ve cheated a lot with my sex life with my boyfriend sucks … but I love getting off. I don’t think I could give that up.”

I do have a worry. I really like being a strong, athletic, energetic guy, which I am. I am usually the strongest guy in the gym, the winner in martial arts sparring, etc. However, I came to the conclusion that I needed castration because I simply couldn’t handle the internal pressure of sexual temptation and distraction -- constant anxiety, constant temptation to use prostitutes or otherwise cheat on my wife, etc. However, I am truly worried about losing too much physical prowess.

Nov. 7:

Almost two days with dying balls. The swelling isn’t very pronounced, just they’re rock hard.

I have been feeling some things they may indicate they are shutting down. I got really flushed in the face (it was like I was constantly blushing, and people asked me about it) and I also got some hot and cold sweats. Another new thing is that I actually feel cold. Normally I just radiate heat and rarely am affected by cold air. So these things could indicate some lowered hormone levels. But could also just be a placebo effect.

Currently it is hard to say if the castration is really working. It still seems too easy, and right now my balls just seem like they did after any number of CBT or ballbusting sessions I’ve done in the past -- and the balls have always recovered from such abuse. But the veterinary literature is really clear that this is a gradual, slow process taking at least three weeks. So we’ll see. I am getting impatient though.

Nov. 8

Three whole days. The veterinary papers say that the swelling subsides after 72 hours, and that seems to be true with me. The balls are hard, but normal sized. I think they do feel different, definitely a different consistency.

I do feel really different though. First of all, for the first time in my life, last night I had trouble getting erect when my wife was fondling me. She noticed it. I just stayed limp and when I was hard it wasn’t’ my normal cock of steel. The touch on the penis feels quite different, hard to describe but just not an immediate sensitivity but more like just another body part.

I also feel really clear headed, and really peaceful. It is the first time in a very long time I feel so relaxed. I still noticed some good looking chicks on the way to work, but I can say I really don’t feel horny. Again maybe it is a placebo effect, but it is probably now enough time that hormonal disruptions would be noticeable.

I’ve noticed a couple other weird little things. For example, I was suddenly struck by the fact that I smell nicer. It is hard to describe, but I actually have several times sniffed my own arm and it smells really nice. I mean I never smell bad, but now I definitely smell good.

My skin has also been doing a few things. The first 24 hours I had various sweating episode. But now I’m sweating less than normal. I usually have night sweats, but last night I really didn’t sweat. I noticed my skin feels much less greasy as well.

I have been doing okay with exercise. Last night I went to my boxing class, and as usual I was the toughest motherfucker in the gym and outlasted everyone. I hope I can keep that up, although I realize it is unlikely. Testosterone really is a key to athletic performance. I could probably stand a loss of strength, but I know I’ll be bothered if my energy, motivation or endurance wane much.

This is my only kernel of “regret” regarding castration -- I wish I could have embraced my natural beautiful maleness. It may sound conceited, but I am a pretty good male specimen -- tall, broad-shouldered, lean, muscular. But my testosterone-fueled urges just kept me in so much inner turmoil I just had to escape it. So I don’t (at least not right now) regret castration, but I do regret that I am “built” such that castration was necessary for peace of mind. It seems like a waste of a great male body to castrate it. I guess worst case I can take testosterone replacement, but that of course is just jumping back into the fire -- it would be a real conundrum if I needed testosterone replacement..

I’ve also been thinking about the fact that most people in the world are actually pretty hormonally deficient. Just driving to work I was looking at all the people who are out of shape, who are diminutive and weak, who are old and worn out, who are ambiguous in their sexuality, who are ugly and unappealing. So I guess it is obviously quite possible to live as a eunuch, just most people never had the chance to have the full-fledged sexuality that I enjoyed the past 25 years.

[derlongus (imported)]

looks like real fast results and changes. (maybe a little bit too fast)

looking forward to the results in 3 weeks.

[SplitDik (imported)]

New message:

Nov 9:

Not much new to report, as I guess daily reporting on a process that needs 45 days is a little boring. I'll keep you posted with anything new. The one new thing is that I'm developing a bruise on the left side of the scrotum. It is small but pronounced. Not sure if it is at one of the injection sites. It is weird though that it developed late, since there was no immediate bruising. I hope it doesn't mean that some calcium chloride is leaking into the scrotum, as the veterinary papers mention that that can cause ulcers in the scrotum skin.

I do think that i feel less horny. I still am attracted to every pretty girl that goes by, but the urgency or edge seems to be gone. Normally I HAVE to masturbate a few times a day, but the last two days I only did it once and it was more of a chore and I did it because I'm interested in whether the ejaculate is changing. So far the ejaculate seems fairly normal in volume and consistency. Not sure how much of my change in libido is just psychological, placebo versus real, but I think there is something subtle happening.

I am getting a bit impatient, but I know the initial necrosis isn't supposed to set in until after the first week and I'm only on day 5.

Regarding pain, i really don't feel any. But I would say the testicles are more sensitive. But this isn't really tenderness, I mean I don't feel anything when I walk around, but if I squeeze them the pain gets more acute more quickly. The only time I've noticed discomfort during "normal" activity was in my boxing class we have to jump rope for seven minutes for warm up and I could feel my balls bouncing and a bit sore, but not enough to stop me.

Haven't had sex with the wife as she's on her period. At this point I don't think she'd notice anything, although if she really inspected my balls I think she'd notice them being hard, and especially the bruise.

Just got back from the gym. My strength and energy seem to be good, haven't lost anything there.

From now on I'll give weekly updates, unless something significant arises.

[knightbird111 (imported)]

So who wants to be the guini pig? Where do I get my hands on this calcium chloride stuff?