Testicular Atrophy?

[allquanator (imported)]

Hi everyone,

I'Ve had severe acne over years and and two weeks ago I got prescribed Spironolactone.

As I have low blood pressure my doctor advised me to start out with 100mg and to test to what extend the side-effect would affect me.

So I took 100mg last friday and I felt exhausted yet in the afternoon. Another thing that I noticed was that my testicles which normally would hang down somehow nestled closer to my crotch. But it was all the time and not like when one comes out of cold water or air with a contradicted scrotum aswell.

I felt so tired the second day that I stopped the medication. Over the weekend and during the week I had to pee frequently. I also notice that my sperm seemed to be more clear then normal.

I talked to my doctor last week and he convinced me to try again on a lower dose and that the side-effects would diminish over time.

But yesterday I had the feeling that my left testicle seems to be smaller then before. It's hard to tell since I never really examined my testicles on that purpose but on the other hand I always thought that my testes were equally big.

It somehow feels softer and defenetely smaller then the right one.

I found this forum and learned that spironolactone is a very weak anti-androgen and that especially testicular atrophy would only occur after month of use.

Can you tell me if it's possible that my testicle shrank from the medication?

I'm very conerned about this and would want to have some backround information before I confront my doctor next week.

sorry for my bad english. I'm not a native speaker

[kristoff]

What you are describing would only happen after a longer period of use, several weeks. It will not occur after only one or two doses. I would suggest you are anticipating side effects more than you are experiencing them. Start slow, give things time.

[allquanator (imported)]

I am _not_ seeking chemical castration. The reason for the treatment is my horrendous acne.

So you think it's impossible!?

[twaddler (imported)]

As I have low blood pressure my doctor advised me to start out with 100mg and to test to what extend the side-effect would affect me.

I have low blood pressure and I find that Spironolactone does *bad* things for me in that area. Dizziness, blackouts, etc. Also it made my usual very-quick-to-bruise nature accelerate a lot, where the slightest bump would cause large bruises. :/

The blackouts were the worst. D: Whereas when I usually stand up I experience orthostatic hypotension blackiness, with Spironolactone that goes from a generally moderate occurence to an extreme menace (falling down during blackiness).

So I took 100mg last friday and I felt exhausted yet in the afternoon. Another thing that I noticed was that my testicles which normally would hang down somehow nestled closer to my crotch. But it was all the time and not like when one comes out of cold water or air with a contradicted scrotum aswell.

That is to be expected.

I felt so tired the second day that I stopped the medication. Over the weekend and during the week I had to pee frequently. I also notice that my sperm seemed to be more clear then normal.

The diuretic effect is common with Spiro. Make sure to increase your liquid intake to prevent dry skin and such.

I talked to my doctor last week and he convinced me to try again on a lower dose and that the side-effects would diminish over time.

Starting at a lower dose and then gradually increasing it would not be a bad idea at all.

Can you tell me if it's po

ssible that my testicle shrank from the medication?

Quite possible. When I first began taking it mine shrank VER

Y quickly, and my penis shrunk down to 1/4 of it's previous size within a couple months time.

For me, Spiro's effect were VERY rapid. Your mileage may very of course.

I am _not_ seeking chemical castration. The reason for the treatment is my horrendous acne.

So you think it's impossible!?

If you are not seeking castration then you MUST reduce your dosage significantly! In my opinion.

If just for acne then maybe you should try pantothenic acid megadoses or something of that nature that will not affect your virility.

[allquanator (imported)]

Quite possible. When I first began taking it mine shrank VERY quickly, and my penis shrunk down to 1/4 of it's previous size within a couple months time.

For me, Spiro's effect were VERY rapid. Your mileage may very of course.

Thank you for sharing your experiences!

I'm really concerned about this. Now about over a week later everything is back to normal but my left testicle is definetly smaller.

Maybe it was smaller before I took the drug but I felt up my testicles before for cancer prevention and lived with them for over 20 years and all the time I thought that I had to equal sized testicles.

From all I've read around the net this should be impossible from just one 100mg dose. I'm afraid that my doctor wouldn't believe me.

Does anyone know if it has atrophied if it would get back to normal size and if not will my virility as a male be affected? (I'm feeling completely as before right now)

[IbPervert (imported)]

I am on some anti depressants and have found that if I take them with food the side effects are either gone or rather mild, so my suggestion would be to take with food (unless the medication specifically says not to!)

Also, I would ask how frequently do you check your balls? If the answer is at least once a day then you have an issue, but if its once a year your mixing apples and oranges.

[bobbie (imported)]

Ball shrinkage will happen over time. The hormones need to be much lower for you see changes. One ball is always a different size of the other. Just like one ball is higher in the sack as the other.

Only way to know if balls are shrinking is to do a very detail measurement. You do not have to be at castration levels to help reduce the acne. Your balls may have a higher level of hormones then in the normal range. If that is the case you only have to lower the hormones to a lower number. Only way to see how the drug is effecting the hormones is to take blood tests.

[Senjougahara (imported)]

I have low blood pressure and I find that Spironolactone does *bad* things for me in that area. Dizziness, blackouts, etc. Also it made my usual very-quick-to-bruise nature accelerate a lot, where the slightest bump would cause large bruises. :/

The blackouts were the worst. D: Whereas when I usually stand up I experience orthostatic hypotension blackiness, with Spironolactone that goes from a generally moderate occurence to an extreme menace (falling down during blackiness).

Can you write more about this condition? Over the past few weeks I've been noticing I get increasingly dizzy when I stand up, sometimes to the point where I have to grab something to support myself. I had a particularly scary episode in the bath last night; I stood up and blacked out. Luckily when I came to a few seconds later I was still leaning against the wall and not face down in the water! Before I started taking Siterone these attacks were both mild and rare.

[_g (imported)]

Can you write more about this condition? Over the past few weeks I've been noticing I get increasingly dizzy when I stand up, sometimes to the point where I have to grab something to support myself. I had a particularly scary episode in the bath last night; I stood up and blacked out. Luckily when I came to a few seconds later I was still leaning against the wall and not face down in the water! Before I started taking Siterone these attacks were both mild and rare.

Get your blood presser checked. Also you could be dehydrated, and as spironolactone can mess with your potassium levels you need to have those checked.

[ramses (imported)]

I would definately try minocycline before screwing with hormones. This old antibiotic is also about to be added to HIV therapy for some of it's uniqu properties. http://www.physorg.com/news188240911.html

http://www.articlesbase.com/acne-articl ... 94374.html

Many people suffer from skin disorders like acne and psoriasis and most of them find themselves at sea when it comes to getting the best possible treatment or remedy for their afflictions. This holds particularly true for acne vulgaris, also know more commonly as pimples, zits, blackheads or whiteheads. It is a relatively common skin disease which affects skin parts such as face, neck, shoulders, chest and back. Acne manifests from the clogging of pores of the sebaceous glands which results in accumulation of sebum. Soon these clogged pores attract Propionicum acne, a bacteria which proceeds to cause inflammation at the affected site by killing white blood cells therein. Acne is found most frequently in teenagers but can also occur in some adults as well as pregnant women.

Like most diseases, acne needs to be remedies from within the body, and medications like minocycline score high in this regard. Which is why a competent dermatologist may prescribe generic minocycline together with a topical medication, so that this skin disorder is treated effectively.So, what is minocycline and how can it help stop your acne right on its tracks? minocycline is an orally ingested antibiotic which not only inhibits the development of the P. acne bacteria and the inflammation that usually accompanies it, but also actively encourages the body’s immune system to attack and eliminate these bacteria.

Minocycline is not available in a topical form (i.,e one which is applied directly on a body part). It should be administered twice a day in 50 mg or 100 mg doses. It is readily absorbed by the system and can be taken along with food or milk. However, it is advisable to take it on an empty stomach, in order to derive its full benefits.

Does minocycline have any major advantages? While some topical antibiotics can turn you sensitive to sunrays, Minocycline has no sun-related side effects. Moreover, unlike common tetracyclines, there is virtually no chance of getting vaginal yeast infections after using Minocycline. What are the side-effects of minocycline, if any? Despite its many plus points, minocycline has a few disadvantages – users may experience abdominal discomfort, indigestion, dizziness etc. Rashes too may occur in rare cases. Its long term use may cause a bluish skin pigmentation, which is reversible.

In case of daily dosages reaching 200 mg, Minocycline is likely to induce vertigo, nausea and vomiting – hence it is advisable to commence with low doses until your tolerance levels are on the higher side. In case of pregnancy, one should avoid the use of minocycline as it can harm the fetus. Also avoid breast-feeding if you have been prescribed minocycline.